Ablation of hemophilic FVIII inhibitors with FVIII priming, cyclophosphamide immune suppression, and rapid tapering of FVIII immune tolerance

The efficacy and toxicity of factor VIII (FVIII) priming, cyclophosphamide immune suppression, and rapid tapering of concurrent FVIII immune tolerance for subjects with hemophilic inhibitors were evaluated. Four subjects with hemophilic inhibitors were studied. Before treatment, inhibitors were pres...

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Veröffentlicht in:	American journal of hematology 2004-06, Vol.76 (2), p.180-184
Hauptverfasser:	Kobrinsky, Nathan L., Sjolander, Diane E., Moser, Deb K., Stegman, Dottie A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Child, Preschool cyclophosphamide Cyclophosphamide - therapeutic use Factor VIII - analysis Factor VIII - antagonists & inhibitors Factor VIII - immunology Factor VIII - therapeutic use Hematologic and hematopoietic diseases Hemophilia A - blood Hemophilia A - therapy hemophilic inhibitor human FVIII Humans Immune Tolerance Immunosuppressive Agents - therapeutic use Infant Medical sciences Platelet diseases and coagulopathies Treatment Outcome
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