Protective Effects of Diets Supplemented with Omega-3 Polyunsaturated Fatty Acids and Calcium Against Colorectal Tumor Formation
This study is to evaluate the effect of dietary omega-3 polyunsaturated fatty acid (ω-3 PUFA) and/or calcium supplementation on colon tissue of the carcinogenic N -methyl- N -nitrosurea (NMU)-injected rats and to investigate this effect by the assessment of the oxidative stress. The rats were divide...
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| Veröffentlicht in: | Digestive diseases and sciences 2008-08, Vol.53 (8), p.2177-2182 |
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| creator | Kenar, Levent Karayilanoglu, Turan Aydin, Ahmet Serdar, Muhittin Kose, Songul Erbil, M. Kemal |
| description | This study is to evaluate the effect of dietary omega-3 polyunsaturated fatty acid (ω-3 PUFA) and/or calcium supplementation on colon tissue of the carcinogenic
N
-methyl-
N
-nitrosurea (NMU)-injected rats and to investigate this effect by the assessment of the oxidative stress. The rats were divided into four groups: those fed with a standard diet, with a diet supplemented by ω-3 PUFA, those fed with a diet with calcium, and those fed with a standard diet with the combination of ω-3 PUFA and calcium. Rats were injected with an intrarectal NMU. After 32 weeks, colon tissue specimens and plasma were taken to histopathologically investigate and analyze tissue superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) activities and erythrocyte MDA levels. The tumor incidences in supplemented-diet groups II and IV were found to be significantly lower when compared with those of the controls (
P
|
| doi_str_mv | 10.1007/s10620-007-0107-8 |
| format | Article |
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N
-methyl-
N
-nitrosurea (NMU)-injected rats and to investigate this effect by the assessment of the oxidative stress. The rats were divided into four groups: those fed with a standard diet, with a diet supplemented by ω-3 PUFA, those fed with a diet with calcium, and those fed with a standard diet with the combination of ω-3 PUFA and calcium. Rats were injected with an intrarectal NMU. After 32 weeks, colon tissue specimens and plasma were taken to histopathologically investigate and analyze tissue superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) activities and erythrocyte MDA levels. The tumor incidences in supplemented-diet groups II and IV were found to be significantly lower when compared with those of the controls (
P
< 0.05). Superoxide dismutase and glutathione peroxidase antioxidative enzyme activities in colorectal tissue were increased in the study groups when compared with control rats (
P
< 0.001) and MDA levels were significantly lower than in the controls (
P
< 0.001) while the levels in group IV were rather decreased than those in group III (
P
= 0.011). These results suggest that the dietary supplementation of PUFA and/or calcium may be useful in the prevention of colorectal tumor formation.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-007-0107-8</identifier><identifier>PMID: 18041586</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Anticarcinogenic Agents - pharmacology ; Biochemistry ; Biological and medical sciences ; Calcium Compounds - pharmacology ; Colon - drug effects ; Colon - enzymology ; Colon - metabolism ; Colorectal Neoplasms - chemically induced ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - prevention & control ; Dietary Supplements ; Disease Models, Animal ; Fatty Acids, Omega-3 - pharmacology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology ; Glutathione Peroxidase - metabolism ; Hepatology ; Male ; Malondialdehyde - blood ; Medicine ; Medicine & Public Health ; Methylnitrosourea ; Oncology ; Original Paper ; Oxidative Stress - drug effects ; Rats ; Rats, Inbred F344 ; Superoxide Dismutase - metabolism ; Transplant Surgery ; Up-Regulation ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Digestive diseases and sciences, 2008-08, Vol.53 (8), p.2177-2182</ispartof><rights>Springer Science+Business Media, LLC 2007</rights><rights>2008 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-1ab31d0e8394032b37ece510b13e7d6f203a1a09c7ca2e4a5e1ce286c8bf2c793</citedby><cites>FETCH-LOGICAL-c430t-1ab31d0e8394032b37ece510b13e7d6f203a1a09c7ca2e4a5e1ce286c8bf2c793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-007-0107-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-007-0107-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20524732$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18041586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kenar, Levent</creatorcontrib><creatorcontrib>Karayilanoglu, Turan</creatorcontrib><creatorcontrib>Aydin, Ahmet</creatorcontrib><creatorcontrib>Serdar, Muhittin</creatorcontrib><creatorcontrib>Kose, Songul</creatorcontrib><creatorcontrib>Erbil, M. Kemal</creatorcontrib><title>Protective Effects of Diets Supplemented with Omega-3 Polyunsaturated Fatty Acids and Calcium Against Colorectal Tumor Formation</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>This study is to evaluate the effect of dietary omega-3 polyunsaturated fatty acid (ω-3 PUFA) and/or calcium supplementation on colon tissue of the carcinogenic
N
-methyl-
N
-nitrosurea (NMU)-injected rats and to investigate this effect by the assessment of the oxidative stress. The rats were divided into four groups: those fed with a standard diet, with a diet supplemented by ω-3 PUFA, those fed with a diet with calcium, and those fed with a standard diet with the combination of ω-3 PUFA and calcium. Rats were injected with an intrarectal NMU. After 32 weeks, colon tissue specimens and plasma were taken to histopathologically investigate and analyze tissue superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) activities and erythrocyte MDA levels. The tumor incidences in supplemented-diet groups II and IV were found to be significantly lower when compared with those of the controls (
P
< 0.05). Superoxide dismutase and glutathione peroxidase antioxidative enzyme activities in colorectal tissue were increased in the study groups when compared with control rats (
P
< 0.001) and MDA levels were significantly lower than in the controls (
P
< 0.001) while the levels in group IV were rather decreased than those in group III (
P
= 0.011). These results suggest that the dietary supplementation of PUFA and/or calcium may be useful in the prevention of colorectal tumor formation.</description><subject>Animals</subject><subject>Anticarcinogenic Agents - pharmacology</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Calcium Compounds - pharmacology</subject><subject>Colon - drug effects</subject><subject>Colon - enzymology</subject><subject>Colon - metabolism</subject><subject>Colorectal Neoplasms - chemically induced</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - prevention & control</subject><subject>Dietary Supplements</subject><subject>Disease Models, Animal</subject><subject>Fatty Acids, Omega-3 - pharmacology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Hepatology</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methylnitrosourea</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Oxidative Stress - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Transplant Surgery</subject><subject>Up-Regulation</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUGL1EAQhYMo7rj6A7xII-gtWtWddJLjMO6osLALrudQ6VTGXpL02N1ZmZs_3R5mcEHwUvWgvnpV8LLsNcIHBKg-BgQtIU8yB0ylfpKtsKxULktdP81WgDppRH2RvQjhHgCaCvXz7AJrKLCs9Sr7fetdZBPtA4urYUgqCDeIT5aT-Lbs9yNPPEfuxS8bf4ibiXeUK3HrxsMyB4qLp-NwSzEexNrYPgiae7Gh0dhlEusd2TlEsXGj88mcRnG3TM6LrfMTRevml9mzgcbAr879Mvu-vbrbfMmvbz5_3ayvc1MoiDlSp7AHrlVTgJKdqthwidCh4qrXgwRFSNCYypDkgkpGw7LWpu4GaapGXWbvT757734uHGI72WB4HGlmt4RWQtVoBUUC3_4D3rvFz-m3VmKhpNQACcITZLwLwfPQ7r2dyB9ahPaYTXvKpj3KYzZtnXbenI2XbuL-ceMcRgLenQEKhsbB02xs-MtJKGVRKZk4eeJCGs079o8f_v_6Hzrepys</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Kenar, Levent</creator><creator>Karayilanoglu, Turan</creator><creator>Aydin, Ahmet</creator><creator>Serdar, Muhittin</creator><creator>Kose, Songul</creator><creator>Erbil, M. 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Psychology</topic><topic>Gastroenterology</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Hepatology</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methylnitrosourea</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Oxidative Stress - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Transplant Surgery</topic><topic>Up-Regulation</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kenar, Levent</creatorcontrib><creatorcontrib>Karayilanoglu, Turan</creatorcontrib><creatorcontrib>Aydin, Ahmet</creatorcontrib><creatorcontrib>Serdar, Muhittin</creatorcontrib><creatorcontrib>Kose, Songul</creatorcontrib><creatorcontrib>Erbil, M. 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Kemal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Effects of Diets Supplemented with Omega-3 Polyunsaturated Fatty Acids and Calcium Against Colorectal Tumor Formation</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>53</volume><issue>8</issue><spage>2177</spage><epage>2182</epage><pages>2177-2182</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>This study is to evaluate the effect of dietary omega-3 polyunsaturated fatty acid (ω-3 PUFA) and/or calcium supplementation on colon tissue of the carcinogenic
N
-methyl-
N
-nitrosurea (NMU)-injected rats and to investigate this effect by the assessment of the oxidative stress. The rats were divided into four groups: those fed with a standard diet, with a diet supplemented by ω-3 PUFA, those fed with a diet with calcium, and those fed with a standard diet with the combination of ω-3 PUFA and calcium. Rats were injected with an intrarectal NMU. After 32 weeks, colon tissue specimens and plasma were taken to histopathologically investigate and analyze tissue superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) activities and erythrocyte MDA levels. The tumor incidences in supplemented-diet groups II and IV were found to be significantly lower when compared with those of the controls (
P
< 0.05). Superoxide dismutase and glutathione peroxidase antioxidative enzyme activities in colorectal tissue were increased in the study groups when compared with control rats (
P
< 0.001) and MDA levels were significantly lower than in the controls (
P
< 0.001) while the levels in group IV were rather decreased than those in group III (
P
= 0.011). These results suggest that the dietary supplementation of PUFA and/or calcium may be useful in the prevention of colorectal tumor formation.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>18041586</pmid><doi>10.1007/s10620-007-0107-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2008-08, Vol.53 (8), p.2177-2182 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20796304 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Anticarcinogenic Agents - pharmacology Biochemistry Biological and medical sciences Calcium Compounds - pharmacology Colon - drug effects Colon - enzymology Colon - metabolism Colorectal Neoplasms - chemically induced Colorectal Neoplasms - metabolism Colorectal Neoplasms - prevention & control Dietary Supplements Disease Models, Animal Fatty Acids, Omega-3 - pharmacology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology Glutathione Peroxidase - metabolism Hepatology Male Malondialdehyde - blood Medicine Medicine & Public Health Methylnitrosourea Oncology Original Paper Oxidative Stress - drug effects Rats Rats, Inbred F344 Superoxide Dismutase - metabolism Transplant Surgery Up-Regulation Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Protective Effects of Diets Supplemented with Omega-3 Polyunsaturated Fatty Acids and Calcium Against Colorectal Tumor Formation |
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