A regulatory role for protease-activated receptor-2 in motivational learning in rats

Serine proteases such as tissue plasminogen activator (tPA), thrombin and neuropsin influence hippocampal plasticity involved in learning and memory by facilitating both synaptic remodelling and long-term potentiation. Given our previous findings that trypsin and its receptor, protease-activated rec...

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Veröffentlicht in:	Neurobiology of learning and memory 2009-10, Vol.92 (3), p.301-309
Hauptverfasser:	Lohman, Rink-Jan, Jones, Nigel C., O’Brien, Terence J., Cocks, Thomas M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animal memory Animals Anxiety Anxiety - drug therapy Anxiety - physiopathology Avoidance Learning - drug effects Avoidance Learning - physiology Behavioral psychophysiology Biological and medical sciences Brain Cerebrospinal fluid Drinking Behavior - drug effects Drinking Behavior - physiology Elevated-plus maze Fear Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - physiology Learning Learning - drug effects Learning - physiology Male Maze Learning - drug effects Maze Learning - physiology Memory Memory - drug effects Memory - physiology Memory Disorders - chemically induced Memory Disorders - physiopathology Morris water maze Motivation Neurobiology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Oligopeptides - cerebrospinal fluid Oligopeptides - pharmacology PAR2 Protease Protease-activated receptor-2 Proteases Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred Strains Receptor, PAR-2 - agonists Receptor, PAR-2 - metabolism Rodents SLIGRL Sucrose Time Factors Trypsin
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