Elucidation of the Transmission of a Novel Mutation in BRCA1 (1125delCT) in a Family with Multiple Cases of Breast Cancer

In a family with multiple members affected by breast cancer we identified the novel mutation 1125delCT (exon 11) in BRCA1. Three out of three offsprings have the novel mutation while the mother affected by breast cancer does not carry the mutation. Linkage analysis revealed the transmission of the h...

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Veröffentlicht in:	Cancer genomics & proteomics 2009-07, Vol.6 (4), p.215-218
Hauptverfasser:	Razis, Evangelia, Belogianni, Ioulia, Siamanta, Vagia, Apessos, Angela, Kyriakopoulou, Vanessa, Papadopoulou, Eirini, Sariyanni, Mahi, Theofilopoulos, Dionysios, Labropoulos, Stefanos, Nasioulas, Georgios
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged, 80 and over BRCA1 Protein - genetics Breast Neoplasms - genetics Family Female Humans Inheritance Patterns - genetics Male Middle Aged Mutation - genetics Pedigree
Online-Zugang:	Volltext
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