Evaluation of Direct Transport Pathways of Glycine Receptor Antagonists and an Angiotensin Antagonist from the Nasal Cavity to the Central Nervous System in the Rat Model

Purpose The aim of this study was to investigate and quantify drug movement to the brain via the neuro-olfactory system after intranasal dosing of four model drugs; three glycine receptor antagonists and one angiotensin antagonist. Methods The drugs were dosed to rats via intranasal or intravenous a...

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Veröffentlicht in:	Pharmaceutical research 2008-07, Vol.25 (7), p.1531-1543
Hauptverfasser:	Charlton, Stuart T., Whetstone, Joanne, Fayinka, Susan T., Read, Kevin D., Illum, Lisbeth, Davis, Stanley S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Angiotensins - antagonists & inhibitors Animals Antagonist drugs Area Under Curve Autoradiography Biochemistry Biological and medical sciences Biological Availability Biological Transport, Active Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Brain - metabolism Central Nervous System - metabolism Chromatography, Liquid General pharmacology Injections, Intravenous Male Mass Spectrometry Medical Law Medical sciences Nasal Cavity - metabolism Nervous system Neurotransmitters Nose Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Rats Rats, Wistar Receptors, Glycine - antagonists & inhibitors Research Paper Tissue Distribution
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