Effects of Cyclohexanonic Long-Chain Fatty Alcohol, tCFA15 on Amino Acids in Diabetic Rat Brain: A Preliminary Study
The aim of this study was to evaluate the effects of streptozotocin-induced type 1diabetes and a subchronic treatment with cyclohexanonic long-chain fatty alcohol, 3-(15-hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen 1-one (tCFA15) on contents of amino acids including aspartate, glutamate, glutamin...
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| Veröffentlicht in: | Neurochemical research 2008-07, Vol.33 (7), p.1189-1195 |
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| creator | Shinbori, Chiko Shirayama, Yukihiko Mitani, Hideaki Saito, Motoaki Satoh, Keisuke |
| description | The aim of this study was to evaluate the effects of streptozotocin-induced type 1diabetes and a subchronic treatment with cyclohexanonic long-chain fatty alcohol, 3-(15-hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen 1-one (tCFA15) on contents of amino acids including aspartate, glutamate, glutamine, GABA, glycine, taurine, alanine, serine, threonine, and arginine in the prefrontal cortex, hippocampus and striatum. Levels of glutamate, threonine, taurine, alanine, arginine, and the ratio of glutamate/glutamine were altered region-differently in the brain of diabetic rats. However, tCFA15 region-specifically antagonized the changes in taurine and arginine levels and the ratio of glutamate/glutamine. The alteration in glutamate/glutamine ratio may indicate that experimental models of type 1 diabetes have abnormalities of neuron-gria interaction in brain. |
| doi_str_mv | 10.1007/s11064-008-9611-2 |
| format | Article |
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Levels of glutamate, threonine, taurine, alanine, arginine, and the ratio of glutamate/glutamine were altered region-differently in the brain of diabetic rats. However, tCFA15 region-specifically antagonized the changes in taurine and arginine levels and the ratio of glutamate/glutamine. The alteration in glutamate/glutamine ratio may indicate that experimental models of type 1 diabetes have abnormalities of neuron-gria interaction in brain.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-008-9611-2</identifier><identifier>PMID: 18338258</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Amino Acids - metabolism ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Blood Glucose - metabolism ; Body Weight - drug effects ; Brain Chemistry - drug effects ; Cell Biology ; Chromatography, High Pressure Liquid ; Cyclohexanones - pharmacology ; Diabetes Mellitus, Experimental - metabolism ; Fatty Alcohols - pharmacology ; Insulin - blood ; Male ; Neurochemistry ; Neurology ; Neurosciences ; Original Paper ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Neurochemical research, 2008-07, Vol.33 (7), p.1189-1195</ispartof><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-2f8a29ac2fb0477fe878f01692844949b14594038d6561a9a60f6d56ab2f03653</citedby><cites>FETCH-LOGICAL-c400t-2f8a29ac2fb0477fe878f01692844949b14594038d6561a9a60f6d56ab2f03653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-008-9611-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-008-9611-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18338258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shinbori, Chiko</creatorcontrib><creatorcontrib>Shirayama, Yukihiko</creatorcontrib><creatorcontrib>Mitani, Hideaki</creatorcontrib><creatorcontrib>Saito, Motoaki</creatorcontrib><creatorcontrib>Satoh, Keisuke</creatorcontrib><title>Effects of Cyclohexanonic Long-Chain Fatty Alcohol, tCFA15 on Amino Acids in Diabetic Rat Brain: A Preliminary Study</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>The aim of this study was to evaluate the effects of streptozotocin-induced type 1diabetes and a subchronic treatment with cyclohexanonic long-chain fatty alcohol, 3-(15-hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen 1-one (tCFA15) on contents of amino acids including aspartate, glutamate, glutamine, GABA, glycine, taurine, alanine, serine, threonine, and arginine in the prefrontal cortex, hippocampus and striatum. 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The alteration in glutamate/glutamine ratio may indicate that experimental models of type 1 diabetes have abnormalities of neuron-gria interaction in brain.</description><subject>Amino Acids - metabolism</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Glucose - metabolism</subject><subject>Body Weight - drug effects</subject><subject>Brain Chemistry - drug effects</subject><subject>Cell Biology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cyclohexanones - pharmacology</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Fatty Alcohols - pharmacology</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1q3DAUhUVpaCZpH6CbIrrIKm6vfixL3Tlupg0MtPRnLWRZyjh4rESSofP21TADgUJXWtzvO1eXg9BbAh8IQPMxEQKCVwCyUoKQir5AK1I3rBIK2Eu0AlamjCg4RxcpPQAUi5JX6JxIxiSt5QrlW--dzQkHj7u9ncLW_TFzmEeLN2G-r7qtGWe8NjnvcTvZsA3TNc7duiU1DjNud-MccGvHIeHCfR5N73Jxf5iMb2JRP-EWf49uGgto4h7_zMuwf43OvJmSe3N6L9Hv9e2v7mu1-fblrms3leUAuaJeGqqMpb4H3jTeyUZ6IEJRybniqie8VhyYHEQtiFFGgBdDLUxPfTm9Zpfo6pj7GMPT4lLWuzFZN01mdmFJmkIjFadNAd__Az6EJc7lb5pS0gjB2AEiR8jGkFJ0Xj_GcVeO0gT0oQ997EOXPvShD02L8-4UvPQ7NzwbpwIKQI9AKqP53sXnzf9P_QuqmZJR</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Shinbori, Chiko</creator><creator>Shirayama, Yukihiko</creator><creator>Mitani, Hideaki</creator><creator>Saito, Motoaki</creator><creator>Satoh, Keisuke</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20080701</creationdate><title>Effects of Cyclohexanonic Long-Chain Fatty Alcohol, tCFA15 on Amino Acids in Diabetic Rat Brain: A Preliminary Study</title><author>Shinbori, Chiko ; Shirayama, Yukihiko ; Mitani, Hideaki ; Saito, Motoaki ; Satoh, Keisuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-2f8a29ac2fb0477fe878f01692844949b14594038d6561a9a60f6d56ab2f03653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Amino Acids - 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| subjects | Amino Acids - metabolism Animals Biochemistry Biomedical and Life Sciences Biomedicine Blood Glucose - metabolism Body Weight - drug effects Brain Chemistry - drug effects Cell Biology Chromatography, High Pressure Liquid Cyclohexanones - pharmacology Diabetes Mellitus, Experimental - metabolism Fatty Alcohols - pharmacology Insulin - blood Male Neurochemistry Neurology Neurosciences Original Paper Rats Rats, Sprague-Dawley |
| title | Effects of Cyclohexanonic Long-Chain Fatty Alcohol, tCFA15 on Amino Acids in Diabetic Rat Brain: A Preliminary Study |
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