Identifying Inhibitory Threshold Values of Repressing Metabolites in CHO Cell Culture Using Multivariate Analysis Methods

Elevation of lactate, ammonia, osmolality, and carbon dioxide to inhibitory levels was reported to have adverse effects on cell growth and protein productivity in mammalian cell culture. Multivariate analysis methods were used to investigate the roles of these repressing metabolites in a fed- batch...

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Veröffentlicht in:	Biotechnology progress 2008-01, Vol.24 (3), p.675-683
Hauptverfasser:	Xing, Zizhuo, Li, Zhengjian, Chow, Vincent, Lee, Steven S
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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