Hindbrain Rhombic Lip Is Comprised of Discrete Progenitor Cell Populations Allocated by Pax6
The lower rhombic lip (LRL) is a germinal zone in the dorsal hindbrain productive of tangentially migrating neurons, streaming extramurally (mossy fiber neurons) or intramurally (climbing fiber neurons). Here we show that LRL territory, operationally defined by Wnt1 expression, is parceled into mole...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2005-12, Vol.48 (6), p.933-947 |
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| container_title | Neuron (Cambridge, Mass.) |
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| creator | Landsberg, Rebecca L. Awatramani, Rajeshwar B. Hunter, Nina L. Farago, Anna F. DiPietrantonio, Heather J. Rodriguez, Carolyn I. Dymecki, Susan M. |
| description | The lower rhombic lip (LRL) is a germinal zone in the dorsal hindbrain productive of tangentially migrating neurons, streaming extramurally (mossy fiber neurons) or intramurally (climbing fiber neurons). Here we show that LRL territory, operationally defined by
Wnt1 expression, is parceled into molecular subdomains predictive of cell fate. Progressing dorsoventrally,
Lmx1a and
Gdf7 expression identifies the primordium for hindbrain choroid plexus epithelial cells;
Math1, for mossy fiber neurons; and immediately ventral to
Math1 yet within
Wnt1
+ territory, a climbing fiber primordium dominated by
Ngn1-expressing cells. Elimination of Pax6 results in expansion of this
Ngn1
+ progenitor pool and reduction in the
Math1
+ pool, with accompanying later enlargement of the climbing fiber nucleus and reductions in mossy fiber nuclei. Pax6 loss also disrupts
Msx expression cell-nonautonomously, suggesting Pax6 may influence LRL progenitor identity indirectly through potentiating BMP signaling. These studies suggest that underlying the diversity and proportions of fates produced by the LRL is a precise suborganization regulated by Pax6. |
| doi_str_mv | 10.1016/j.neuron.2005.11.031 |
| format | Article |
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Wnt1 expression, is parceled into molecular subdomains predictive of cell fate. Progressing dorsoventrally,
Lmx1a and
Gdf7 expression identifies the primordium for hindbrain choroid plexus epithelial cells;
Math1, for mossy fiber neurons; and immediately ventral to
Math1 yet within
Wnt1
+ territory, a climbing fiber primordium dominated by
Ngn1-expressing cells. Elimination of Pax6 results in expansion of this
Ngn1
+ progenitor pool and reduction in the
Math1
+ pool, with accompanying later enlargement of the climbing fiber nucleus and reductions in mossy fiber nuclei. Pax6 loss also disrupts
Msx expression cell-nonautonomously, suggesting Pax6 may influence LRL progenitor identity indirectly through potentiating BMP signaling. These studies suggest that underlying the diversity and proportions of fates produced by the LRL is a precise suborganization regulated by Pax6.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/j.neuron.2005.11.031</identifier><identifier>PMID: 16364898</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Afferent Pathways - cytology ; Afferent Pathways - embryology ; Afferent Pathways - metabolism ; Animals ; Basic Helix-Loop-Helix Transcription Factors - genetics ; Basic Helix-Loop-Helix Transcription Factors - metabolism ; Body Patterning - genetics ; Bone Morphogenetic Proteins - genetics ; Bone Morphogenetic Proteins - metabolism ; Cell Differentiation - genetics ; Cell Movement - genetics ; Cerebellum - cytology ; Cerebellum - embryology ; Cerebellum - metabolism ; Choroid Plexus - cytology ; Choroid Plexus - embryology ; Choroid Plexus - metabolism ; Climbing ; Derivatives ; Eye Proteins - genetics ; Eye Proteins - metabolism ; Gene Expression Regulation, Developmental - genetics ; Growth Differentiation Factors ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; LIM-Homeodomain Proteins ; Mice ; Mice, Transgenic ; Microscopy ; Nerve Fibers - metabolism ; Nerve Fibers - ultrastructure ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Neurons ; Olivary Nucleus - cytology ; Olivary Nucleus - embryology ; Olivary Nucleus - metabolism ; Paired Box Transcription Factors - genetics ; Paired Box Transcription Factors - metabolism ; PAX6 Transcription Factor ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; Rhombencephalon - cytology ; Rhombencephalon - embryology ; Rhombencephalon - metabolism ; Rodents ; Stem Cells - cytology ; Stem Cells - metabolism ; Transcription Factors ; Wnt1 Protein - genetics ; Wnt1 Protein - metabolism</subject><ispartof>Neuron (Cambridge, Mass.), 2005-12, Vol.48 (6), p.933-947</ispartof><rights>2005 Elsevier Inc.</rights><rights>Copyright Elsevier Limited Dec 22, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-8e5c94cd65226446b71a6956b508a7190d1e74e7eedc8be85a904eba0e8422423</citedby><cites>FETCH-LOGICAL-c551t-8e5c94cd65226446b71a6956b508a7190d1e74e7eedc8be85a904eba0e8422423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0896627305010433$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16364898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Landsberg, Rebecca L.</creatorcontrib><creatorcontrib>Awatramani, Rajeshwar B.</creatorcontrib><creatorcontrib>Hunter, Nina L.</creatorcontrib><creatorcontrib>Farago, Anna F.</creatorcontrib><creatorcontrib>DiPietrantonio, Heather J.</creatorcontrib><creatorcontrib>Rodriguez, Carolyn I.</creatorcontrib><creatorcontrib>Dymecki, Susan M.</creatorcontrib><title>Hindbrain Rhombic Lip Is Comprised of Discrete Progenitor Cell Populations Allocated by Pax6</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>The lower rhombic lip (LRL) is a germinal zone in the dorsal hindbrain productive of tangentially migrating neurons, streaming extramurally (mossy fiber neurons) or intramurally (climbing fiber neurons). Here we show that LRL territory, operationally defined by
Wnt1 expression, is parceled into molecular subdomains predictive of cell fate. Progressing dorsoventrally,
Lmx1a and
Gdf7 expression identifies the primordium for hindbrain choroid plexus epithelial cells;
Math1, for mossy fiber neurons; and immediately ventral to
Math1 yet within
Wnt1
+ territory, a climbing fiber primordium dominated by
Ngn1-expressing cells. Elimination of Pax6 results in expansion of this
Ngn1
+ progenitor pool and reduction in the
Math1
+ pool, with accompanying later enlargement of the climbing fiber nucleus and reductions in mossy fiber nuclei. Pax6 loss also disrupts
Msx expression cell-nonautonomously, suggesting Pax6 may influence LRL progenitor identity indirectly through potentiating BMP signaling. These studies suggest that underlying the diversity and proportions of fates produced by the LRL is a precise suborganization regulated by Pax6.</description><subject>Afferent Pathways - cytology</subject><subject>Afferent Pathways - embryology</subject><subject>Afferent Pathways - metabolism</subject><subject>Animals</subject><subject>Basic Helix-Loop-Helix Transcription Factors - genetics</subject><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>Body Patterning - genetics</subject><subject>Bone Morphogenetic Proteins - genetics</subject><subject>Bone Morphogenetic Proteins - metabolism</subject><subject>Cell Differentiation - genetics</subject><subject>Cell Movement - genetics</subject><subject>Cerebellum - cytology</subject><subject>Cerebellum - embryology</subject><subject>Cerebellum - metabolism</subject><subject>Choroid Plexus - cytology</subject><subject>Choroid Plexus - embryology</subject><subject>Choroid Plexus - metabolism</subject><subject>Climbing</subject><subject>Derivatives</subject><subject>Eye Proteins - genetics</subject><subject>Eye Proteins - metabolism</subject><subject>Gene Expression Regulation, Developmental - genetics</subject><subject>Growth Differentiation Factors</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>LIM-Homeodomain Proteins</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Microscopy</subject><subject>Nerve Fibers - metabolism</subject><subject>Nerve Fibers - ultrastructure</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neurons</subject><subject>Olivary Nucleus - cytology</subject><subject>Olivary Nucleus - embryology</subject><subject>Olivary Nucleus - metabolism</subject><subject>Paired Box Transcription Factors - genetics</subject><subject>Paired Box Transcription Factors - metabolism</subject><subject>PAX6 Transcription Factor</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>Rhombencephalon - cytology</subject><subject>Rhombencephalon - embryology</subject><subject>Rhombencephalon - metabolism</subject><subject>Rodents</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><subject>Transcription Factors</subject><subject>Wnt1 Protein - genetics</subject><subject>Wnt1 Protein - metabolism</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNFqFDEUhoNY7Lb6BiIBwbuZ5swkmeRGKFttCwtdRO-EkMmc1SwzyZrMSPv2puyC4IXn5tx8_zk_HyFvgdXAQF7t64BLiqFuGBM1QM1aeEFWwHRXcdD6JVkxpWUlm649Jxc57xkDLjS8IucgW8mVVivy_c6HoU_WB_rlZ5x67-jGH-h9pus4HZLPONC4ozc-u4Qz0m2KPzD4OSa6xnGk23hYRjv7GDK9Hsfo7FwS_RPd2kf5mpzt7JjxzWlfkm-fP31d31Wbh9v79fWmckLAXCkUTnM3SNE0knPZd2ClFrIXTNkONBsAO44d4uBUj0pYzTj2lqHiTcOb9pJ8ON49pPhrwTybqfQt9WzAuGTTsE4p1fICvv8H3MclhdLNgGCtFGXaQvEj5VLMOeHOFBGTTU8GmHl2b_bm6N48uzcAprgvsXen40s_4fA3dJJdgI9HAIuL3x6Tyc5jcDj4hG42Q_T___AHuAqWAg</recordid><startdate>20051222</startdate><enddate>20051222</enddate><creator>Landsberg, Rebecca L.</creator><creator>Awatramani, Rajeshwar B.</creator><creator>Hunter, Nina L.</creator><creator>Farago, Anna F.</creator><creator>DiPietrantonio, Heather J.</creator><creator>Rodriguez, Carolyn I.</creator><creator>Dymecki, Susan M.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20051222</creationdate><title>Hindbrain Rhombic Lip Is Comprised of Discrete Progenitor Cell Populations Allocated by Pax6</title><author>Landsberg, Rebecca L. ; Awatramani, Rajeshwar B. ; Hunter, Nina L. ; Farago, Anna F. ; DiPietrantonio, Heather J. ; Rodriguez, Carolyn I. ; Dymecki, Susan M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-8e5c94cd65226446b71a6956b508a7190d1e74e7eedc8be85a904eba0e8422423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Afferent Pathways - cytology</topic><topic>Afferent Pathways - embryology</topic><topic>Afferent Pathways - metabolism</topic><topic>Animals</topic><topic>Basic Helix-Loop-Helix Transcription Factors - genetics</topic><topic>Basic Helix-Loop-Helix Transcription Factors - metabolism</topic><topic>Body Patterning - genetics</topic><topic>Bone Morphogenetic Proteins - genetics</topic><topic>Bone Morphogenetic Proteins - metabolism</topic><topic>Cell Differentiation - genetics</topic><topic>Cell Movement - genetics</topic><topic>Cerebellum - cytology</topic><topic>Cerebellum - embryology</topic><topic>Cerebellum - metabolism</topic><topic>Choroid Plexus - cytology</topic><topic>Choroid Plexus - embryology</topic><topic>Choroid Plexus - metabolism</topic><topic>Climbing</topic><topic>Derivatives</topic><topic>Eye Proteins - genetics</topic><topic>Eye Proteins - metabolism</topic><topic>Gene Expression Regulation, Developmental - genetics</topic><topic>Growth Differentiation Factors</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>LIM-Homeodomain Proteins</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Microscopy</topic><topic>Nerve Fibers - metabolism</topic><topic>Nerve Fibers - ultrastructure</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Neurons</topic><topic>Olivary Nucleus - cytology</topic><topic>Olivary Nucleus - embryology</topic><topic>Olivary Nucleus - metabolism</topic><topic>Paired Box Transcription Factors - genetics</topic><topic>Paired Box Transcription Factors - metabolism</topic><topic>PAX6 Transcription Factor</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><topic>Rhombencephalon - cytology</topic><topic>Rhombencephalon - embryology</topic><topic>Rhombencephalon - metabolism</topic><topic>Rodents</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><topic>Transcription Factors</topic><topic>Wnt1 Protein - genetics</topic><topic>Wnt1 Protein - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Landsberg, Rebecca L.</creatorcontrib><creatorcontrib>Awatramani, Rajeshwar B.</creatorcontrib><creatorcontrib>Hunter, Nina L.</creatorcontrib><creatorcontrib>Farago, Anna F.</creatorcontrib><creatorcontrib>DiPietrantonio, Heather J.</creatorcontrib><creatorcontrib>Rodriguez, Carolyn I.</creatorcontrib><creatorcontrib>Dymecki, Susan M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Landsberg, Rebecca L.</au><au>Awatramani, Rajeshwar B.</au><au>Hunter, Nina L.</au><au>Farago, Anna F.</au><au>DiPietrantonio, Heather J.</au><au>Rodriguez, Carolyn I.</au><au>Dymecki, Susan M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hindbrain Rhombic Lip Is Comprised of Discrete Progenitor Cell Populations Allocated by Pax6</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>2005-12-22</date><risdate>2005</risdate><volume>48</volume><issue>6</issue><spage>933</spage><epage>947</epage><pages>933-947</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>The lower rhombic lip (LRL) is a germinal zone in the dorsal hindbrain productive of tangentially migrating neurons, streaming extramurally (mossy fiber neurons) or intramurally (climbing fiber neurons). Here we show that LRL territory, operationally defined by
Wnt1 expression, is parceled into molecular subdomains predictive of cell fate. Progressing dorsoventrally,
Lmx1a and
Gdf7 expression identifies the primordium for hindbrain choroid plexus epithelial cells;
Math1, for mossy fiber neurons; and immediately ventral to
Math1 yet within
Wnt1
+ territory, a climbing fiber primordium dominated by
Ngn1-expressing cells. Elimination of Pax6 results in expansion of this
Ngn1
+ progenitor pool and reduction in the
Math1
+ pool, with accompanying later enlargement of the climbing fiber nucleus and reductions in mossy fiber nuclei. Pax6 loss also disrupts
Msx expression cell-nonautonomously, suggesting Pax6 may influence LRL progenitor identity indirectly through potentiating BMP signaling. These studies suggest that underlying the diversity and proportions of fates produced by the LRL is a precise suborganization regulated by Pax6.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16364898</pmid><doi>10.1016/j.neuron.2005.11.031</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuron (Cambridge, Mass.), 2005-12, Vol.48 (6), p.933-947 |
| issn | 0896-6273 1097-4199 |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Afferent Pathways - cytology Afferent Pathways - embryology Afferent Pathways - metabolism Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Body Patterning - genetics Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Cell Differentiation - genetics Cell Movement - genetics Cerebellum - cytology Cerebellum - embryology Cerebellum - metabolism Choroid Plexus - cytology Choroid Plexus - embryology Choroid Plexus - metabolism Climbing Derivatives Eye Proteins - genetics Eye Proteins - metabolism Gene Expression Regulation, Developmental - genetics Growth Differentiation Factors Homeodomain Proteins - genetics Homeodomain Proteins - metabolism LIM-Homeodomain Proteins Mice Mice, Transgenic Microscopy Nerve Fibers - metabolism Nerve Fibers - ultrastructure Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Olivary Nucleus - cytology Olivary Nucleus - embryology Olivary Nucleus - metabolism Paired Box Transcription Factors - genetics Paired Box Transcription Factors - metabolism PAX6 Transcription Factor Repressor Proteins - genetics Repressor Proteins - metabolism Rhombencephalon - cytology Rhombencephalon - embryology Rhombencephalon - metabolism Rodents Stem Cells - cytology Stem Cells - metabolism Transcription Factors Wnt1 Protein - genetics Wnt1 Protein - metabolism |
| title | Hindbrain Rhombic Lip Is Comprised of Discrete Progenitor Cell Populations Allocated by Pax6 |
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