EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines

Allelic loss in chromosome 3p is one of the most frequent and earliest genetic events in lung carcinogenesis. We investigated if the loss of microRNA-128b, a microRNA located on chromosome 3p and a putative regulator of epidermal growth factor receptor (EGFR), correlated with response to targeted EG...

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Veröffentlicht in:	Annals of oncology 2008-06, Vol.19 (6), p.1053-1059
Hauptverfasser:	Weiss, G.J., Bemis, L.T., Nakajima, E., Sugita, M., Birks, D.K., Robinson, W.A., Varella-Garcia, M., Bunn, P.A., Haney, J., Helfrich, B.A., Kato, H., Hirsch, F.R., Franklin, W.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Cell Line, Tumor epidermal growth factor receptor Gefitinib Gene Expression Genes, erbB-1 - genetics Humans Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - mortality Medical sciences microRNA MicroRNAs non-small-cell lung cancer Pharmacology. Drug treatments Pneumology Quinazolines - therapeutic use Survival Analysis Tumors of the respiratory system and mediastinum
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