Structure and Mechanism of Kainate Receptor Modulation by Anions

L-glutamate, the major excitatory neurotransmitter in the human brain, activates a family of ligand-gated ion channels, the major subtypes of which are named AMPA, kainate, and NMDA receptors. In common with many signal transduction proteins, glutamate receptors are modulated by ions and small molec...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2007-03, Vol.53 (6), p.829-841
Hauptverfasser:	Plested, Andrew J.R., Mayer, Mark L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anions - pharmacology Binding sites Binding Sites - drug effects Cell Line, Transformed Crystallography - methods Drug Interactions Glutamic Acid - pharmacology Humans Ligands Membrane Potentials - drug effects Membrane Potentials - radiation effects Models, Molecular MOLNEURO Mutagenesis - physiology Neural networks Patch-Clamp Techniques Polyamines Protein Conformation - drug effects PROTEINS Receptors, Kainic Acid - chemistry Receptors, Kainic Acid - drug effects SIGNALING Structure-Activity Relationship Transfection - methods
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