Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China
Background/AimsTo investigate clinical characteristics and prognosis of paediatric optic neuritis (PON) in patients seropositive for myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in China.MethodsChildren displaying initial onset of optic neuritis (ON) were recruited from the Neuro-ophthalmol...
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| Veröffentlicht in: | British journal of ophthalmology 2019-06, Vol.103 (6), p.831-836 |
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| creator | Song, Honglu Zhou, Huanfen Yang, Mo Tan, Shaoying Wang, Junqing Xu, Quangang Liu, Hongjuan Wei, Shihui |
| description | Background/AimsTo investigate clinical characteristics and prognosis of paediatric optic neuritis (PON) in patients seropositive for myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in China.MethodsChildren displaying initial onset of optic neuritis (ON) were recruited from the Neuro-ophthalmology Department in the Chinese People’s Liberation Army General Hospital from January 2016 to August 2017. They were assigned into three groups based on antibody status: MOG-Ab-seropositive ON (MOG-ON), aquaporin-4 antibody-seropositive ON (AQP4-ON) and double seronegative ON (seronegative-ON).ResultsTotally 48 patients were assessed, including 25 MOG-ON (52.1%), 7 AQP4-ON (14.6%) and 16 seronegative-ON (33.3%). The MOG-ON and seronegative-ON cohorts had equal ratios of female/male, but the AQP4-ON cohort was predominantly females (100%). The patients with MOG-ON were significantly younger at onset compared with the AQP4-ON group. Of the MOG-ON eyes, 97.6% had good recovery of visual acuity (VA) (≥0.5) compared with33.3% of AQP4-ON eyes (p |
| doi_str_mv | 10.1136/bjophthalmol-2018-312399 |
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They were assigned into three groups based on antibody status: MOG-Ab-seropositive ON (MOG-ON), aquaporin-4 antibody-seropositive ON (AQP4-ON) and double seronegative ON (seronegative-ON).ResultsTotally 48 patients were assessed, including 25 MOG-ON (52.1%), 7 AQP4-ON (14.6%) and 16 seronegative-ON (33.3%). The MOG-ON and seronegative-ON cohorts had equal ratios of female/male, but the AQP4-ON cohort was predominantly females (100%). The patients with MOG-ON were significantly younger at onset compared with the AQP4-ON group. Of the MOG-ON eyes, 97.6% had good recovery of visual acuity (VA) (≥0.5) compared with33.3% of AQP4-ON eyes (p<0.001). However, there was no significant difference compared with the seronegative-ON eyes (82.6%, p=0.052). Two children in the MOG-ON group ended up being diagnosed with acute disseminated encephalomyelitis, while only one patient in the AQP4-ON group developed neuromyelitis optica during follow-up. Patients with MOG-ON had thicker peripapillary retinal nerve fibre layers overall and in the superior and inferior quadrants than in patients with AQP4-ON (p=0.005, p=0.002 and p=0.024, respectively). In addition, the macular ganglion cell-inner plexiform in MOG-ON eyes became significantly thicker than in AQP4-ON eyes (p=0.029). Orbital MRI revealed a larger proportion of patients with MOG-ON had intracranial optic nerve involvement than patients with seronegative-ON (51.2% vs 17.4%, p=0.009).ConclusionMOG-ON was the most common PON subtype in China. MOG-ON had different clinical features including earlier age of onset, equal female/male ratio, better recovery of VA and thicker peripapillary retinal nerve fibre and macular ganglion cell-inner plexiform layers. MOG-Abs may be a potential biomarker for determining visual prognosis with PON.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjophthalmol-2018-312399</identifier><identifier>PMID: 30049802</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Adolescent ; Antigens ; Aquaporins ; Autoantibodies - immunology ; Child ; Child, Preschool ; China - epidemiology ; Encephalomyelitis ; Female ; Follow-Up Studies ; Glycoproteins ; Humans ; Immunoglobulins ; Incidence ; Magnetic Resonance Imaging ; Male ; Medical prognosis ; Multiple sclerosis ; Myelin-Oligodendrocyte Glycoprotein - immunology ; Nervous system ; Ophthalmology ; Optic Nerve - pathology ; Optic Neuritis - diagnosis ; Optic Neuritis - epidemiology ; Optic Neuritis - immunology ; Patients ; Pediatrics ; Prognosis ; Retina - diagnostic imaging ; Retrospective Studies ; Tomography, Optical Coherence ; Visual Acuity</subject><ispartof>British journal of ophthalmology, 2019-06, Vol.103 (6), p.831-836</ispartof><rights>Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2019 Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b387t-d6378f25a450839c6210ad43148e786838fdee02a5f1b514f0c4ec5a627dd59c3</citedby><cites>FETCH-LOGICAL-b387t-d6378f25a450839c6210ad43148e786838fdee02a5f1b514f0c4ec5a627dd59c3</cites><orcidid>0000-0003-0752-6956</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30049802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Honglu</creatorcontrib><creatorcontrib>Zhou, Huanfen</creatorcontrib><creatorcontrib>Yang, Mo</creatorcontrib><creatorcontrib>Tan, Shaoying</creatorcontrib><creatorcontrib>Wang, Junqing</creatorcontrib><creatorcontrib>Xu, Quangang</creatorcontrib><creatorcontrib>Liu, Hongjuan</creatorcontrib><creatorcontrib>Wei, Shihui</creatorcontrib><title>Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Background/AimsTo investigate clinical characteristics and prognosis of paediatric optic neuritis (PON) in patients seropositive for myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in China.MethodsChildren displaying initial onset of optic neuritis (ON) were recruited from the Neuro-ophthalmology Department in the Chinese People’s Liberation Army General Hospital from January 2016 to August 2017. They were assigned into three groups based on antibody status: MOG-Ab-seropositive ON (MOG-ON), aquaporin-4 antibody-seropositive ON (AQP4-ON) and double seronegative ON (seronegative-ON).ResultsTotally 48 patients were assessed, including 25 MOG-ON (52.1%), 7 AQP4-ON (14.6%) and 16 seronegative-ON (33.3%). The MOG-ON and seronegative-ON cohorts had equal ratios of female/male, but the AQP4-ON cohort was predominantly females (100%). The patients with MOG-ON were significantly younger at onset compared with the AQP4-ON group. Of the MOG-ON eyes, 97.6% had good recovery of visual acuity (VA) (≥0.5) compared with33.3% of AQP4-ON eyes (p<0.001). However, there was no significant difference compared with the seronegative-ON eyes (82.6%, p=0.052). Two children in the MOG-ON group ended up being diagnosed with acute disseminated encephalomyelitis, while only one patient in the AQP4-ON group developed neuromyelitis optica during follow-up. Patients with MOG-ON had thicker peripapillary retinal nerve fibre layers overall and in the superior and inferior quadrants than in patients with AQP4-ON (p=0.005, p=0.002 and p=0.024, respectively). In addition, the macular ganglion cell-inner plexiform in MOG-ON eyes became significantly thicker than in AQP4-ON eyes (p=0.029). Orbital MRI revealed a larger proportion of patients with MOG-ON had intracranial optic nerve involvement than patients with seronegative-ON (51.2% vs 17.4%, p=0.009).ConclusionMOG-ON was the most common PON subtype in China. MOG-ON had different clinical features including earlier age of onset, equal female/male ratio, better recovery of VA and thicker peripapillary retinal nerve fibre and macular ganglion cell-inner plexiform layers. MOG-Abs may be a potential biomarker for determining visual prognosis with PON.</description><subject>Adolescent</subject><subject>Antigens</subject><subject>Aquaporins</subject><subject>Autoantibodies - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>China - epidemiology</subject><subject>Encephalomyelitis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glycoproteins</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Incidence</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Multiple sclerosis</subject><subject>Myelin-Oligodendrocyte Glycoprotein - immunology</subject><subject>Nervous system</subject><subject>Ophthalmology</subject><subject>Optic Nerve - pathology</subject><subject>Optic Neuritis - diagnosis</subject><subject>Optic Neuritis - epidemiology</subject><subject>Optic Neuritis - immunology</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Prognosis</subject><subject>Retina - diagnostic imaging</subject><subject>Retrospective Studies</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Acuity</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkc2q1TAUhYMo3uPVV5CAEyfV_LRpOpSDf3DBiY5Dmuyek0Pa1CQV-gI-t_tyriKOHIVkf2tlsxYhlLM3nEv1dryk9VzPNs4pNoJx3Ugu5DA8IgfeKo1P_fCYHBhjfcO54jfkWSkXvArF-6fkRjLWDpqJA_l5jGEJzkbqzjZbVyGHUoMr1C6erjmdllRCoWmi8w7I0hTDKXlYfE5ur0BPcXcJwQo4tEsNY_J7UyCnFZU1_AC6WvDB1hwcTSua0wW2jKNCUXI8h8U-J08mGwu8eDhvybcP778ePzV3Xz5-Pr67a0ap-9p4JXs9ic62HdNycEpwZn0reauh10pLPXkAJmw38bHj7cRcC66zSvTed4OTt-T11RcX_r5BqWYOxUGMdoG0FYPB6U4rjAfRV_-gl7TlBbczQkiB-alWIqWvlMuplAyTWXOYbd4NZ-a-K_N3V-a-K3PtCqUvHz7Yxhn8H-HvchCQV2CcL_9v-wvTOKfT</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Song, Honglu</creator><creator>Zhou, Huanfen</creator><creator>Yang, Mo</creator><creator>Tan, Shaoying</creator><creator>Wang, Junqing</creator><creator>Xu, Quangang</creator><creator>Liu, Hongjuan</creator><creator>Wei, Shihui</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0752-6956</orcidid></search><sort><creationdate>201906</creationdate><title>Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China</title><author>Song, Honglu ; Zhou, Huanfen ; Yang, Mo ; Tan, Shaoying ; Wang, Junqing ; Xu, Quangang ; Liu, Hongjuan ; Wei, Shihui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b387t-d6378f25a450839c6210ad43148e786838fdee02a5f1b514f0c4ec5a627dd59c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Antigens</topic><topic>Aquaporins</topic><topic>Autoantibodies - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>China - epidemiology</topic><topic>Encephalomyelitis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glycoproteins</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Incidence</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Multiple sclerosis</topic><topic>Myelin-Oligodendrocyte Glycoprotein - immunology</topic><topic>Nervous system</topic><topic>Ophthalmology</topic><topic>Optic Nerve - pathology</topic><topic>Optic Neuritis - diagnosis</topic><topic>Optic Neuritis - epidemiology</topic><topic>Optic Neuritis - immunology</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Prognosis</topic><topic>Retina - diagnostic imaging</topic><topic>Retrospective Studies</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Honglu</creatorcontrib><creatorcontrib>Zhou, Huanfen</creatorcontrib><creatorcontrib>Yang, Mo</creatorcontrib><creatorcontrib>Tan, Shaoying</creatorcontrib><creatorcontrib>Wang, Junqing</creatorcontrib><creatorcontrib>Xu, Quangang</creatorcontrib><creatorcontrib>Liu, Hongjuan</creatorcontrib><creatorcontrib>Wei, Shihui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Honglu</au><au>Zhou, Huanfen</au><au>Yang, Mo</au><au>Tan, Shaoying</au><au>Wang, Junqing</au><au>Xu, Quangang</au><au>Liu, Hongjuan</au><au>Wei, Shihui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2019-06</date><risdate>2019</risdate><volume>103</volume><issue>6</issue><spage>831</spage><epage>836</epage><pages>831-836</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><abstract>Background/AimsTo investigate clinical characteristics and prognosis of paediatric optic neuritis (PON) in patients seropositive for myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in China.MethodsChildren displaying initial onset of optic neuritis (ON) were recruited from the Neuro-ophthalmology Department in the Chinese People’s Liberation Army General Hospital from January 2016 to August 2017. They were assigned into three groups based on antibody status: MOG-Ab-seropositive ON (MOG-ON), aquaporin-4 antibody-seropositive ON (AQP4-ON) and double seronegative ON (seronegative-ON).ResultsTotally 48 patients were assessed, including 25 MOG-ON (52.1%), 7 AQP4-ON (14.6%) and 16 seronegative-ON (33.3%). The MOG-ON and seronegative-ON cohorts had equal ratios of female/male, but the AQP4-ON cohort was predominantly females (100%). The patients with MOG-ON were significantly younger at onset compared with the AQP4-ON group. Of the MOG-ON eyes, 97.6% had good recovery of visual acuity (VA) (≥0.5) compared with33.3% of AQP4-ON eyes (p<0.001). However, there was no significant difference compared with the seronegative-ON eyes (82.6%, p=0.052). Two children in the MOG-ON group ended up being diagnosed with acute disseminated encephalomyelitis, while only one patient in the AQP4-ON group developed neuromyelitis optica during follow-up. Patients with MOG-ON had thicker peripapillary retinal nerve fibre layers overall and in the superior and inferior quadrants than in patients with AQP4-ON (p=0.005, p=0.002 and p=0.024, respectively). In addition, the macular ganglion cell-inner plexiform in MOG-ON eyes became significantly thicker than in AQP4-ON eyes (p=0.029). Orbital MRI revealed a larger proportion of patients with MOG-ON had intracranial optic nerve involvement than patients with seronegative-ON (51.2% vs 17.4%, p=0.009).ConclusionMOG-ON was the most common PON subtype in China. MOG-ON had different clinical features including earlier age of onset, equal female/male ratio, better recovery of VA and thicker peripapillary retinal nerve fibre and macular ganglion cell-inner plexiform layers. MOG-Abs may be a potential biomarker for determining visual prognosis with PON.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>30049802</pmid><doi>10.1136/bjophthalmol-2018-312399</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0752-6956</orcidid></addata></record> |
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| subjects | Adolescent Antigens Aquaporins Autoantibodies - immunology Child Child, Preschool China - epidemiology Encephalomyelitis Female Follow-Up Studies Glycoproteins Humans Immunoglobulins Incidence Magnetic Resonance Imaging Male Medical prognosis Multiple sclerosis Myelin-Oligodendrocyte Glycoprotein - immunology Nervous system Ophthalmology Optic Nerve - pathology Optic Neuritis - diagnosis Optic Neuritis - epidemiology Optic Neuritis - immunology Patients Pediatrics Prognosis Retina - diagnostic imaging Retrospective Studies Tomography, Optical Coherence Visual Acuity |
| title | Clinical characteristics and prognosis of myelin oligodendrocyte glycoprotein antibody-seropositive paediatric optic neuritis in China |
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