Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes

Heterozygous somatic mutations in spliceosome genes ( , or ) occur in >50% of patients with myelodysplastic syndrome (MDS). These mutations occur early in disease development, suggesting that they contribute to MDS pathogenesis and may represent a unique genetic vulnerability for targeted therapy...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-09, Vol.78 (18), p.5363-5374
Hauptverfasser:	Nguyen, Hai Dang, Leong, Wan Yee, Li, Weiling, Reddy, Pavankumar N G, Sullivan, Jack D, Walter, Matthew J, Zou, Lee, Graubert, Timothy A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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