Activation of GLP-1 receptor signalling alleviates cellular stresses and improves beta cell function in a mouse model of Wolfram syndrome

Aims/hypothesis Loss of functional beta cells results in a gradual progression of insulin insufficiency in Wolfram syndrome caused by recessive WFS1 mutations. However, beta cell dysfunction in Wolfram syndrome has yet to be fully characterised, and there are also no specific treatment recommendatio...

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Veröffentlicht in:	Diabetologia 2018-10, Vol.61 (10), p.2189-2201
Hauptverfasser:	Kondo, Manabu, Tanabe, Katsuya, Amo-Shiinoki, Kikuko, Hatanaka, Masayuki, Morii, Tsukasa, Takahashi, Harumi, Seino, Susumu, Yamada, Yuichiro, Tanizawa, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AMP Animals Beta cells Cellular stress response Chronic effects Diabetes Diabetes mellitus Endoplasmic reticulum Endoplasmic Reticulum - metabolism Exenatide - pharmacology Female GLP-1 receptor agonists Glucagon Glucagon-like peptide 1 Glucagon-Like Peptide-1 Receptor - metabolism Glucose Glucose - chemistry Glucose tolerance Glucose Tolerance Test Human Physiology Humans Hyperglycemia Immunoreactivity Initiation factor eIF-2α Insulin Insulin - metabolism Insulin secretion Insulin-Secreting Cells - cytology Insulin-Secreting Cells - pathology Internal Medicine Islets of Langerhans - pathology Liraglutide - pharmacology Male Medicine Medicine & Public Health Membrane Proteins - genetics Metabolic Diseases Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Fluorescence Pancreas Perfusion Retrospective Studies Signal Transduction - drug effects Thioredoxin Transcription Wolfram Syndrome - metabolism
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