Getting a Notch closer to renal dysfunction: activated Notch suppresses expression of the adaptor protein Disabled‐2 in tubular epithelial cells

ABSTRACT Reactivation of Notch signaling in kidneys of animal models and patients with chronic kidney disease (CKD) has been shown to contribute to epithelial injury and fibrosis development. Here, we investigated the mechanisms of Notch‐induced injury in renal epithelial cells. We performed genome‐...

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Veröffentlicht in:	The FASEB journal 2019-01, Vol.33 (1), p.821-832
Hauptverfasser:	Schütte-Nütgen, Katharina, Edeling, Maria, Mendl, Gudrun, Krahn, Michael P., Edemir, Bayram, Weide, Thomas, Kremerskothen, Joachim, Michgehl, Ulf, Pavenstädt, Hermann
Format:	Artikel
Sprache:	eng
Schlagworte:	Dab2 endocytosis kidney function NICD1
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