The hippocampal engram maps experience but not place
Episodic memories are encoded by a sparse population of hippocampal neurons. In mice, optogenetic manipulation of this memory engram established that these neurons are indispensable and inducing for memory recall. However, little is known about their in vivo activity or precise role in memory. We fo...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2018-07, Vol.361 (6400), p.392-397 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Tanaka, Kazumasa Z He, Hongshen Tomar, Anupratap Niisato, Kazue Huang, Arthur J Y McHugh, Thomas J |
| description | Episodic memories are encoded by a sparse population of hippocampal neurons. In mice, optogenetic manipulation of this memory engram established that these neurons are indispensable and inducing for memory recall. However, little is known about their in vivo activity or precise role in memory. We found that during memory encoding, only a fraction of CA1 place cells function as engram neurons, distinguished by firing repetitive bursts paced at the theta frequency. During memory recall, these neurons remained highly context specific, yet demonstrated preferential remapping of their place fields. These data demonstrate a dissociation of precise spatial coding and contextual indexing by distinct hippocampal ensembles and suggest that the hippocampal engram serves as an index of memory content. |
| doi_str_mv | 10.1126/science.aat5397 |
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In mice, optogenetic manipulation of this memory engram established that these neurons are indispensable and inducing for memory recall. However, little is known about their in vivo activity or precise role in memory. We found that during memory encoding, only a fraction of CA1 place cells function as engram neurons, distinguished by firing repetitive bursts paced at the theta frequency. During memory recall, these neurons remained highly context specific, yet demonstrated preferential remapping of their place fields. 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| subjects | Action Potentials Animals Brain Mapping c-Fos protein CA1 Region, Hippocampal - cytology CA1 Region, Hippocampal - physiology Coding Cognitive ability Cognitive Mapping Exploration Fear of Success Firing pattern Gene mapping Hippocampus Memory Memory, Episodic Mental Recall Mice Mice, Transgenic Neural coding Neurons Neurons - physiology Optogenetics Proto-Oncogene Proteins c-fos - analysis Proto-Oncogene Proteins c-fos - genetics Recall Theta Rhythm Theta rhythms |
| title | The hippocampal engram maps experience but not place |
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