Article: mGluR1/5-Dependent Long-Term Depression Requires the Regulated Ectodomain Cleavage of Neuronal Pentraxin NPR by TACE

Matrix metalloproteases (MMPs) play a role in remodeling the extracellular matrix during brain development and have been implicated in synaptic plasticity. Here, we report that a member of the neuronal pentraxin (NP) family, neuronal pentraxin receptor (NPR), undergoes regulated cleavage by the MMP...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2008-03, Vol.57 (6), p.858-871
Hauptverfasser: Cho, Richard W, Park, Joo Min, Wolff, Steffen B E, Xu, Desheng, Hopf, Carsten, Kim, Jin-ah, Reddy, Radhika C, Petralia, Ronald S, Perin, Mark S, Linden, David J, Worley, Paul F
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container_issue 6
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container_title Neuron (Cambridge, Mass.)
container_volume 57
creator Cho, Richard W
Park, Joo Min
Wolff, Steffen B E
Xu, Desheng
Hopf, Carsten
Kim, Jin-ah
Reddy, Radhika C
Petralia, Ronald S
Perin, Mark S
Linden, David J
Worley, Paul F
description Matrix metalloproteases (MMPs) play a role in remodeling the extracellular matrix during brain development and have been implicated in synaptic plasticity. Here, we report that a member of the neuronal pentraxin (NP) family, neuronal pentraxin receptor (NPR), undergoes regulated cleavage by the MMP tumor necrosis factor- converting enzyme (TACE). NPR is enriched at excitatory synapses where it associates with AMPA-type glutamate receptors (AMPAR) and enhances synaptogenesis. However, in response to activation of group 1 mGluRs (mGluR1/5), TACE cleaves NPR and releases the pentraxin domain from its N-terminal transmembrane domain. Cleaved NPR rapidly accumulates in endosomes where it colocalizes with AMPAR. This process is necessary for mGluR1/5-dependent LTD in hippocampal and cerebellar synapses. These observations suggest that cleaved NPR functions to 'capture' AMPAR for endocytosis and reveal a bifunctional role of NPs in both synapse strengthening and weakening.
doi_str_mv 10.1016/j.neuron.2008.01.010
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title Article: mGluR1/5-Dependent Long-Term Depression Requires the Regulated Ectodomain Cleavage of Neuronal Pentraxin NPR by TACE
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