Uncertainties in individual doses in a case–control study of thyroid cancer after the Chernobyl accident
Individual radiation doses to the thyroid were reconstructed for 2239 subjects of a case–control study of thyroid cancer among young people that was carried out in regions of Belarus and Russia contaminated by radioactive fallout from the Chernobyl accident. Although the process of dose reconstructi...
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| Veröffentlicht in: | Radiation protection dosimetry 2007-01, Vol.127 (1-4), p.540-543 |
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| container_title | Radiation protection dosimetry |
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| creator | Drozdovitch, V. Maceika, E. Khrouch, V. Zvonova, I. Vlasov, O. Bouville, A. Cardis, E. |
| description | Individual radiation doses to the thyroid were reconstructed for 2239 subjects of a case–control study of thyroid cancer among young people that was carried out in regions of Belarus and Russia contaminated by radioactive fallout from the Chernobyl accident. Although the process of dose reconstruction provides a point estimate of each subject's dose, it is obvious that there is uncertainty associated with these dose calculations. The following main sources of uncertainty in the estimated individual doses were identified: (1) shared and unshared errors associated with parameters of the dosimetry model; and (2) unshared errors that are associated with the variability, reliability and ability of information from the personal interviews. Besides setting up proper distributions for the parameters of the dosimetry model, inter-individual correlations were also defined to take into account shared errors. By the application of Monte Carlo simulations, a set of approximately log-normally distributed thyroid doses was obtained for each subject; the geometric standard deviations of the distributions are found to vary among individuals from 1.7 to 3.7. |
| doi_str_mv | 10.1093/rpd/ncm360 |
| format | Article |
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Although the process of dose reconstruction provides a point estimate of each subject's dose, it is obvious that there is uncertainty associated with these dose calculations. The following main sources of uncertainty in the estimated individual doses were identified: (1) shared and unshared errors associated with parameters of the dosimetry model; and (2) unshared errors that are associated with the variability, reliability and ability of information from the personal interviews. Besides setting up proper distributions for the parameters of the dosimetry model, inter-individual correlations were also defined to take into account shared errors. By the application of Monte Carlo simulations, a set of approximately log-normally distributed thyroid doses was obtained for each subject; the geometric standard deviations of the distributions are found to vary among individuals from 1.7 to 3.7.</description><identifier>ISSN: 0144-8420</identifier><identifier>EISSN: 1742-3406</identifier><identifier>DOI: 10.1093/rpd/ncm360</identifier><identifier>PMID: 17634207</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Body Burden ; Case-Control Studies ; Chernobyl Nuclear Accident ; Data Interpretation, Statistical ; Humans ; Incidence ; Neoplasms, Radiation-Induced - epidemiology ; Radiation Dosage ; Radiation Monitoring - statistics & numerical data ; Relative Biological Effectiveness ; Reproducibility of Results ; Risk Assessment - methods ; Risk Factors ; Sensitivity and Specificity ; Thyroid Neoplasms - epidemiology</subject><ispartof>Radiation protection dosimetry, 2007-01, Vol.127 (1-4), p.540-543</ispartof><rights>The Author 2007. 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Although the process of dose reconstruction provides a point estimate of each subject's dose, it is obvious that there is uncertainty associated with these dose calculations. The following main sources of uncertainty in the estimated individual doses were identified: (1) shared and unshared errors associated with parameters of the dosimetry model; and (2) unshared errors that are associated with the variability, reliability and ability of information from the personal interviews. Besides setting up proper distributions for the parameters of the dosimetry model, inter-individual correlations were also defined to take into account shared errors. By the application of Monte Carlo simulations, a set of approximately log-normally distributed thyroid doses was obtained for each subject; the geometric standard deviations of the distributions are found to vary among individuals from 1.7 to 3.7.</description><subject>Body Burden</subject><subject>Case-Control Studies</subject><subject>Chernobyl Nuclear Accident</subject><subject>Data Interpretation, Statistical</subject><subject>Humans</subject><subject>Incidence</subject><subject>Neoplasms, Radiation-Induced - epidemiology</subject><subject>Radiation Dosage</subject><subject>Radiation Monitoring - statistics & numerical data</subject><subject>Relative Biological Effectiveness</subject><subject>Reproducibility of Results</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Thyroid Neoplasms - epidemiology</subject><issn>0144-8420</issn><issn>1742-3406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtuFDEQhi0EIpOEDQdA3sAiUhO_ut2zJJM3IWyIQNlYbruscehpD7Y7yuxyB27ISXDUo7BDKlVJVZ8-qX6E3lLykZI5P4xreziYFW_ICzSjUrCKC9K8RDNChahawcgO2k3pjhAm57V4jXaobHhZyxm6uxkMxKz9kD0k7IdS1t97O-oe25CmncZGJ_jz-NuEIcfQ45RHu8HB4bzcxOBtuT95sHa59LwEvFhCHEK36bE2xlsY8j565XSf4M127qGb05Nvi_Pq6uvZxeLTVWV4K3LVMqBcszklneuAWtHV1LhWUgrlH-o6Yp1lsumK1zqwkto5qxsm27qtO9B8D32YvOsYfo2Qslr5ZKDv9QBhTKr83TIhaAEPJtDEkFIEp9bRr3TcKErUU7KqJKumZAv8bmsduxXYf-g2ygK8n4Awrv8vqibOpwwPz6SOP1UjuazV-Y9b9f3689HxpbxVX_hfOV6UBg</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Drozdovitch, V.</creator><creator>Maceika, E.</creator><creator>Khrouch, V.</creator><creator>Zvonova, I.</creator><creator>Vlasov, O.</creator><creator>Bouville, A.</creator><creator>Cardis, E.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20070101</creationdate><title>Uncertainties in individual doses in a case–control study of thyroid cancer after the Chernobyl accident</title><author>Drozdovitch, V. ; 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Although the process of dose reconstruction provides a point estimate of each subject's dose, it is obvious that there is uncertainty associated with these dose calculations. The following main sources of uncertainty in the estimated individual doses were identified: (1) shared and unshared errors associated with parameters of the dosimetry model; and (2) unshared errors that are associated with the variability, reliability and ability of information from the personal interviews. Besides setting up proper distributions for the parameters of the dosimetry model, inter-individual correlations were also defined to take into account shared errors. By the application of Monte Carlo simulations, a set of approximately log-normally distributed thyroid doses was obtained for each subject; the geometric standard deviations of the distributions are found to vary among individuals from 1.7 to 3.7.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>17634207</pmid><doi>10.1093/rpd/ncm360</doi><tpages>4</tpages></addata></record> |
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| ispartof | Radiation protection dosimetry, 2007-01, Vol.127 (1-4), p.540-543 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Body Burden Case-Control Studies Chernobyl Nuclear Accident Data Interpretation, Statistical Humans Incidence Neoplasms, Radiation-Induced - epidemiology Radiation Dosage Radiation Monitoring - statistics & numerical data Relative Biological Effectiveness Reproducibility of Results Risk Assessment - methods Risk Factors Sensitivity and Specificity Thyroid Neoplasms - epidemiology |
| title | Uncertainties in individual doses in a case–control study of thyroid cancer after the Chernobyl accident |
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