Drug cross‐resistance and therapy‐induced resistance in chronic lymphocytic leukaemia by an enhanced method of individualised tumour response testing

Summary Previous results with individualised tumour response testing (ITRT) in vitro in chronic lymphocytic leukaemia (CLL) have consistently shown good correlation with patient response and survival. We describe here an improved test and report its use with samples from the Leukaemia Research Fund...

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Veröffentlicht in:	British journal of haematology 2009-08, Vol.146 (4), p.384-395
Hauptverfasser:	Bosanquet, Andrew G., Richards, Sue M., Wade, Rachel, Else, Monica, Matutes, Estella, Dyer, Martin J. S., Rassam, Saad M. B., Durant, Justin, Scadding, Sheila M., Raper, Steve L., Dearden, Claire E., Catovsky, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Apoptosis Biological and medical sciences cytotoxic drug resistance Dose-Response Relationship, Drug Drug Resistance, Multiple Drug Resistance, Neoplasm Drug Screening Assays, Antitumor - methods Hematologic and hematopoietic diseases Humans individualised tumour response testing Inhibitory Concentration 50 ITRT Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes - drug effects Medical sciences pentostatin tumour response to anti‐neoplastic compounds assay
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