Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine/chemokine production in endothelial cells via activation of both mitogen-activated protein kinases and nuclear factor-κB

It has been well documented that both endogenous inflammatory mediator advanced glycation end products (AGEs) and exogenous inflammatory inducer lipopolysaccharide play key roles in the initiation and development of inflammatory diseases. However, the combined inflammation-stimulatory effect of AGEs...

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Veröffentlicht in:	The FEBS journal 2009-08, Vol.276 (16), p.4598-4606
Hauptverfasser:	Liu, Jinghua, Zhao, Shanchao, Tang, Jing, Li, Zhijie, Zhong, Tianyu, Liu, Yawei, Chen, Dengyu, Zhao, Mingzhe, Li, Yusheng, Gong, Xiaowei, Deng, Peng, Wang, Jiang H, Jiang, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	advanced glycation end products cytokines/chemokines human umbilical vein endothelial cells inflammation interleukin-6 interleukin-8 lipopolysaccharide lipopolysaccharides MAP kinases mitogen-activated protein kinase NF-κB phosphorylation serum albumin signal transduction synergism transcription factor NF-kappa B
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