The use of a mutant TNF-α as a vaccine adjuvant for the induction of mucosal immune responses

Abstract Safe and potent adjuvants are required in order to establish effective mucosal vaccines. Cytokines are promising adjuvants because they are human-derived safe biomaterial and display immune-modulating functions. We have created a mutant tumor necrosis factor-α (TNF-α), mTNF-K90R, that exhib...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biomaterials 2009-10, Vol.30 (29), p.5869-5876
Hauptverfasser:	Kayamuro, Hiroyuki, Abe, Yasuhiro, Yoshioka, Yasuo, Katayama, Kazufumi, Nomura, Tetsuya, Yoshida, Tokuyuki, Yamashita, Kohei, Yoshikawa, Tomoaki, Kawai, Yuichi, Mayumi, Tadanori, Hiroi, Takachika, Itoh, Norio, Nagano, Kazuya, Kamada, Haruhiko, Tsunoda, Shin-ichi, Tsutsumi, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Advanced Basic Science Animals Bioactivity Cytokine Dentistry Female Immunity, Innate - drug effects Immunity, Innate - immunology Immunomodulation Influenza virus Mice Mice, Inbred BALB C Mucosa Mucous Membrane - drug effects Mucous Membrane - immunology Mutation Tumor Necrosis Factor-alpha - administration & dosage Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Vaccines - administration & dosage Vaccines - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!