Cancer dose–response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity

A cancer dose–response assessment was conducted for acrylonitrile (AN) using updated information on mechanism of action, epidemiology, toxicity, and pharmacokinetics. Although more than 10 chronic bioassays indicate that AN produces multiple tumors in rats and mice, a number of large, well-conducted...

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Veröffentlicht in:	Regulatory toxicology and pharmacology 2005-10, Vol.43 (1), p.85-103
Hauptverfasser:	Kirman, C.R., Gargas, M.L., Marsh, G.M., Strother, D.E., Klaunig, J.E., Collins, J.J., Deskin, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylonitrile Acrylonitrile - administration & dosage Acrylonitrile - toxicity Administration, Oral Animals Brain Neoplasms - chemically induced Brain Neoplasms - epidemiology Brain Neoplasms - mortality Cancer dose–response assessment Carcinogenicity Tests Carcinogens - administration & dosage Carcinogens - toxicity Dose-Response Relationship, Drug Environmental Exposure - standards Epidemiology Humans Incidence Inhalation Exposure Lung Neoplasms - chemically induced Lung Neoplasms - epidemiology Lung Neoplasms - mortality Meta-Analysis as Topic Mice Mode of action Models, Biological Mutagenicity Tests Nonlinear Dynamics PBPK modeling Rats Species differences
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