Genes encoded within 8q24 on the amplicon of a large extrachromosomal element are selectively repressed during the terminal differentiation of HL-60 cells

Human acute myeloblastic leukemia HL-60 cells become resistant to differentiation during long-term cultivation. After 150 passages, double minute chromosomes (dmins) found in early-passaged cells are replaced by large extrachromosomal elements (LEEs). In a DNA library derived from a purified fractio...

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Veröffentlicht in:	Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 2008-04, Vol.640 (1-2), p.97-106
Hauptverfasser:	Hirano, Tetsuo, Ike, Fumio, Murata, Takehide, Obata, Yuichi, Utiyama, Hiroyasu, Yokoyama, Kazunari K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Differentiation Chromosome Mapping Chromosomes, Human, Pair 8 Double minute chromosome Extrachromosomal Inheritance Gene Amplification Gene Expression Gene Library Genetic instability Genomic Instability HL-60 Cells Humans In Situ Hybridization, Fluorescence Large extrachromosomal element Models, Genetic Reverse Transcriptase Polymerase Chain Reaction Sequence Tagged Sites Terminal differentiation
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