Ultra-potent Antibodies Against Respiratory Syncytial Virus: Effects of Binding Kinetics and Binding Valence on Viral Neutralization

We describe here the selection of ultra-potent anti-respiratory syncytial virus (RSV) antibodies for preventing RSV infection. A large number of antibody variants derived from Synagis ® (palivizumab), an anti-RSV monoclonal antibody that targets RSV F protein, were generated by a directed evolution...

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Veröffentlicht in:	Journal of molecular biology 2005-07, Vol.350 (1), p.126-144
Hauptverfasser:	Wu, Herren, Pfarr, David S., Tang, Ying, An, Ling-Ling, Patel, Nita K., Watkins, Jeffry D., Huse, William D., Kiener, Peter A., Young, James F.
Format:	Artikel
Sprache:	eng
Schlagworte:	affinity maturation Amino Acid Sequence Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibodies, Monoclonal, Humanized Antibodies, Viral - chemistry Antibodies, Viral - genetics Antibodies, Viral - immunology Cell Line Cercopithecus aethiops Enzyme-Linked Immunosorbent Assay Humans Kinetics kinetics manipulation Models, Molecular Molecular Sequence Data Mutation - genetics Neutralization Tests Palivizumab Protein Structure, Tertiary Respiratory syncytial virus Respiratory Syncytial Virus Infections - genetics Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Viruses - genetics Respiratory Syncytial Viruses - immunology Synagis
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