Polymorphic variations in the expression of the chemical detoxifying UDP glucuronosyltransferases

The UDP glucuronosyltransferases (UGT) are expressed predominantly in the liver and gastrointestinal tract in humans. Their expression varies widely between individuals, due in part to coding region polymorphisms that alter catalytic function and in part, to differences in the regulation of UGT gene...

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Veröffentlicht in:	Toxicology and applied pharmacology 2005-09, Vol.207 (2), p.77-83
Hauptverfasser:	Mackenzie, P.I., Gregory, P.A., Lewinsky, R.H., Yasmin, S.N., Height, T., McKinnon, R.A., Gardner-Stephen, D.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Expression Regulation, Enzymologic - physiology Gene regulation Glucuronosyltransferase - genetics Glucuronosyltransferase - metabolism Humans Inactivation, Metabolic Polymorphism, Genetic Polymorphisms Promoter Regions, Genetic Transcription Factors - genetics Transcription Factors - physiology UDP glucuronosyltransferases
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