Tacrolimus ointment in the treatment of occupationally induced chronic hand dermatitis
Background: Occupational hand dermatitis (OHD) is a common and often chronic condition. Usage of topical corticosteroids is limited in long‐term therapy because of potential side‐effects. New treatment options are highly appreciated. Objective: To study efficacy and safety of tacrolimus in patient...
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| Veröffentlicht in: | Contact dermatitis 2008-05, Vol.58 (5), p.299-306 |
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| creator | Schliemann, Sibylle Kelterer, Daniela Bauer, Andrea John, Swen M. Skudlik, Christoph Schindera, Ingo Wehrmann, Wolfgang Elsner, Peter |
| description | Background: Occupational hand dermatitis (OHD) is a common and often chronic condition. Usage of topical corticosteroids is limited in long‐term therapy because of potential side‐effects. New treatment options are highly appreciated.
Objective: To study efficacy and safety of tacrolimus in patients suffering from OHD.
Patients and Methods: In a prospective, open, multicentre study, 29 patients with OHD of predominantly mild‐to‐moderate severity were treated with tacrolimus ointment (Protopic® 0.1%) during a 4‐week active treatment period with twice daily application followed by a 2‐month optional treatment period. Efficacy was evaluated by the use of a standardized hand eczema score and by clinical severity rating, conducted on all study visits (screening, baseline and weeks 2, 4, 6, and 12). Adverse events were recorded for safety evaluation.
Results: The hand eczema score declined significantly after 2 weeks of treatment compared with baseline and further declined until the end of the study. Finally, 12 (44%) patients were clear of hand eczema. Worsening of the dermatitis occurred in 2 patients (7%). Clinical grading indicated improvement too. Overall tolerability was good.
Conclusion: Topical tacrolimus might be an efficacious treatment option for chronic OHD. Blinded and randomized controlled studies are necessary to confirm the results of this pilot study. |
| doi_str_mv | 10.1111/j.1600-0536.2007.01314.x |
| format | Article |
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Objective: To study efficacy and safety of tacrolimus in patients suffering from OHD.
Patients and Methods: In a prospective, open, multicentre study, 29 patients with OHD of predominantly mild‐to‐moderate severity were treated with tacrolimus ointment (Protopic® 0.1%) during a 4‐week active treatment period with twice daily application followed by a 2‐month optional treatment period. Efficacy was evaluated by the use of a standardized hand eczema score and by clinical severity rating, conducted on all study visits (screening, baseline and weeks 2, 4, 6, and 12). Adverse events were recorded for safety evaluation.
Results: The hand eczema score declined significantly after 2 weeks of treatment compared with baseline and further declined until the end of the study. Finally, 12 (44%) patients were clear of hand eczema. Worsening of the dermatitis occurred in 2 patients (7%). Clinical grading indicated improvement too. Overall tolerability was good.
Conclusion: Topical tacrolimus might be an efficacious treatment option for chronic OHD. Blinded and randomized controlled studies are necessary to confirm the results of this pilot study.</description><identifier>ISSN: 0105-1873</identifier><identifier>EISSN: 1600-0536</identifier><identifier>DOI: 10.1111/j.1600-0536.2007.01314.x</identifier><identifier>PMID: 18416762</identifier><identifier>CODEN: CODEDG</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Cutaneous ; Adult ; Aged ; allergic contact dermatitis ; Allergic diseases ; Biological and medical sciences ; Dermatitis, Occupational - diagnosis ; Dermatitis, Occupational - drug therapy ; Disease Susceptibility ; Female ; Hand Dermatoses - diagnosis ; Hand Dermatoses - drug therapy ; Humans ; Immunopathology ; Immunosuppressive Agents - adverse effects ; Immunosuppressive Agents - therapeutic use ; irritant contact dermatitis ; Male ; Medical sciences ; Middle Aged ; occupational ; occupational contact dermatitis ; Occupations ; Prospective Studies ; Severity of Illness Index ; Skin allergic diseases. Stinging insect allergies ; Tacrolimus - adverse effects ; Tacrolimus - therapeutic use ; tacrolimus ointment ; therapy ; Treatment Outcome</subject><ispartof>Contact dermatitis, 2008-05, Vol.58 (5), p.299-306</ispartof><rights>2008 The Authors</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5164-20d3300a664cd694339911da3ee5123a6966d45aeedbbeb870815c53f72d47bb3</citedby><cites>FETCH-LOGICAL-c5164-20d3300a664cd694339911da3ee5123a6966d45aeedbbeb870815c53f72d47bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0536.2007.01314.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0536.2007.01314.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20267968$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18416762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schliemann, Sibylle</creatorcontrib><creatorcontrib>Kelterer, Daniela</creatorcontrib><creatorcontrib>Bauer, Andrea</creatorcontrib><creatorcontrib>John, Swen M.</creatorcontrib><creatorcontrib>Skudlik, Christoph</creatorcontrib><creatorcontrib>Schindera, Ingo</creatorcontrib><creatorcontrib>Wehrmann, Wolfgang</creatorcontrib><creatorcontrib>Elsner, Peter</creatorcontrib><title>Tacrolimus ointment in the treatment of occupationally induced chronic hand dermatitis</title><title>Contact dermatitis</title><addtitle>Contact Dermatitis</addtitle><description>Background: Occupational hand dermatitis (OHD) is a common and often chronic condition. Usage of topical corticosteroids is limited in long‐term therapy because of potential side‐effects. New treatment options are highly appreciated.
Objective: To study efficacy and safety of tacrolimus in patients suffering from OHD.
Patients and Methods: In a prospective, open, multicentre study, 29 patients with OHD of predominantly mild‐to‐moderate severity were treated with tacrolimus ointment (Protopic® 0.1%) during a 4‐week active treatment period with twice daily application followed by a 2‐month optional treatment period. Efficacy was evaluated by the use of a standardized hand eczema score and by clinical severity rating, conducted on all study visits (screening, baseline and weeks 2, 4, 6, and 12). Adverse events were recorded for safety evaluation.
Results: The hand eczema score declined significantly after 2 weeks of treatment compared with baseline and further declined until the end of the study. Finally, 12 (44%) patients were clear of hand eczema. Worsening of the dermatitis occurred in 2 patients (7%). Clinical grading indicated improvement too. Overall tolerability was good.
Conclusion: Topical tacrolimus might be an efficacious treatment option for chronic OHD. Blinded and randomized controlled studies are necessary to confirm the results of this pilot study.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Aged</subject><subject>allergic contact dermatitis</subject><subject>Allergic diseases</subject><subject>Biological and medical sciences</subject><subject>Dermatitis, Occupational - diagnosis</subject><subject>Dermatitis, Occupational - drug therapy</subject><subject>Disease Susceptibility</subject><subject>Female</subject><subject>Hand Dermatoses - diagnosis</subject><subject>Hand Dermatoses - drug therapy</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>irritant contact dermatitis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>occupational</subject><subject>occupational contact dermatitis</subject><subject>Occupations</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>Tacrolimus - adverse effects</subject><subject>Tacrolimus - therapeutic use</subject><subject>tacrolimus ointment</subject><subject>therapy</subject><subject>Treatment Outcome</subject><issn>0105-1873</issn><issn>1600-0536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE-P1CAYh4nRuOOuX8Fw0VvrC7RADx7M6K5uJu5l1_VGKNAMY_-M0GZnvv1SOxmvcoG8PD943wchTCAnaX3c5YQDZFAynlMAkQNhpMgPL9DqfPESrYBAmREp2AV6E-MOgPCCytfogsiCcMHpCv281yYMre-miAffj53rR-x7PG4dHoPTS2Fo8GDMtNejH3rdtseE2Mk4i802DL03eKt7i60LXUJGH6_Qq0a30b097Zfo4frr_fpbtrm7-b7-vMlMmXrJKFjGADTnhbG8KhirKkKsZs6VhDLNK85tUWrnbF27WgqQpDQlawS1hahrdok-LO_uw_BncnFUnY_Gta3u3TBFRUEILiVPoFzANG2MwTVqH3ynw1ERULNTtVOzOjWrU7NT9depOqTou9MfU905-y94kpiA9ydAR6PbJuje-HjmKFAuKi4T92nhnnzrjv_dgFrffZlPKZ8teR9HdzjndfituGCiVI8_btS1vL19_LWhirNn_juhog</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>Schliemann, Sibylle</creator><creator>Kelterer, Daniela</creator><creator>Bauer, Andrea</creator><creator>John, Swen M.</creator><creator>Skudlik, Christoph</creator><creator>Schindera, Ingo</creator><creator>Wehrmann, Wolfgang</creator><creator>Elsner, Peter</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>200805</creationdate><title>Tacrolimus ointment in the treatment of occupationally induced chronic hand dermatitis</title><author>Schliemann, Sibylle ; Kelterer, Daniela ; Bauer, Andrea ; John, Swen M. ; Skudlik, Christoph ; Schindera, Ingo ; Wehrmann, Wolfgang ; Elsner, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5164-20d3300a664cd694339911da3ee5123a6966d45aeedbbeb870815c53f72d47bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Aged</topic><topic>allergic contact dermatitis</topic><topic>Allergic diseases</topic><topic>Biological and medical sciences</topic><topic>Dermatitis, Occupational - diagnosis</topic><topic>Dermatitis, Occupational - drug therapy</topic><topic>Disease Susceptibility</topic><topic>Female</topic><topic>Hand Dermatoses - diagnosis</topic><topic>Hand Dermatoses - drug therapy</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>irritant contact dermatitis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>occupational</topic><topic>occupational contact dermatitis</topic><topic>Occupations</topic><topic>Prospective Studies</topic><topic>Severity of Illness Index</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>Tacrolimus - adverse effects</topic><topic>Tacrolimus - therapeutic use</topic><topic>tacrolimus ointment</topic><topic>therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schliemann, Sibylle</creatorcontrib><creatorcontrib>Kelterer, Daniela</creatorcontrib><creatorcontrib>Bauer, Andrea</creatorcontrib><creatorcontrib>John, Swen M.</creatorcontrib><creatorcontrib>Skudlik, Christoph</creatorcontrib><creatorcontrib>Schindera, Ingo</creatorcontrib><creatorcontrib>Wehrmann, Wolfgang</creatorcontrib><creatorcontrib>Elsner, Peter</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Contact dermatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schliemann, Sibylle</au><au>Kelterer, Daniela</au><au>Bauer, Andrea</au><au>John, Swen M.</au><au>Skudlik, Christoph</au><au>Schindera, Ingo</au><au>Wehrmann, Wolfgang</au><au>Elsner, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tacrolimus ointment in the treatment of occupationally induced chronic hand dermatitis</atitle><jtitle>Contact dermatitis</jtitle><addtitle>Contact Dermatitis</addtitle><date>2008-05</date><risdate>2008</risdate><volume>58</volume><issue>5</issue><spage>299</spage><epage>306</epage><pages>299-306</pages><issn>0105-1873</issn><eissn>1600-0536</eissn><coden>CODEDG</coden><abstract>Background: Occupational hand dermatitis (OHD) is a common and often chronic condition. Usage of topical corticosteroids is limited in long‐term therapy because of potential side‐effects. New treatment options are highly appreciated.
Objective: To study efficacy and safety of tacrolimus in patients suffering from OHD.
Patients and Methods: In a prospective, open, multicentre study, 29 patients with OHD of predominantly mild‐to‐moderate severity were treated with tacrolimus ointment (Protopic® 0.1%) during a 4‐week active treatment period with twice daily application followed by a 2‐month optional treatment period. Efficacy was evaluated by the use of a standardized hand eczema score and by clinical severity rating, conducted on all study visits (screening, baseline and weeks 2, 4, 6, and 12). Adverse events were recorded for safety evaluation.
Results: The hand eczema score declined significantly after 2 weeks of treatment compared with baseline and further declined until the end of the study. Finally, 12 (44%) patients were clear of hand eczema. Worsening of the dermatitis occurred in 2 patients (7%). Clinical grading indicated improvement too. Overall tolerability was good.
Conclusion: Topical tacrolimus might be an efficacious treatment option for chronic OHD. Blinded and randomized controlled studies are necessary to confirm the results of this pilot study.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18416762</pmid><doi>10.1111/j.1600-0536.2007.01314.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Contact dermatitis, 2008-05, Vol.58 (5), p.299-306 |
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| subjects | Administration, Cutaneous Adult Aged allergic contact dermatitis Allergic diseases Biological and medical sciences Dermatitis, Occupational - diagnosis Dermatitis, Occupational - drug therapy Disease Susceptibility Female Hand Dermatoses - diagnosis Hand Dermatoses - drug therapy Humans Immunopathology Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use irritant contact dermatitis Male Medical sciences Middle Aged occupational occupational contact dermatitis Occupations Prospective Studies Severity of Illness Index Skin allergic diseases. Stinging insect allergies Tacrolimus - adverse effects Tacrolimus - therapeutic use tacrolimus ointment therapy Treatment Outcome |
| title | Tacrolimus ointment in the treatment of occupationally induced chronic hand dermatitis |
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