The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis

Abstract Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), can be induced by the immunization of mice with myelin antigens in the form of myelin oligodendrocyte glycoprotein (MOG). Macrophage colony-stimulating factor (M-CSF) is required for the development...

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Veröffentlicht in:	Journal of neuroimmunology 2008-03, Vol.195 (1), p.73-80
Hauptverfasser:	Uemura, Yasunori, Ohno, Hiroaki, Ohzeki, Yumiko, Takanashi, Hiromi, Murooka, Hideko, Kubo, Kazuo, Serizawa, Isao
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigens, CD - metabolism c-fms Cell Proliferation - drug effects Cytokines - metabolism Dose-Response Relationship, Drug Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - prevention & control Experimental autoimmune encephalomyelitis Flow Cytometry - methods Ki20227 Lymphocyte Activation - drug effects M-CSF Male Mice Mice, Inbred C57BL Myelin Proteins Myelin-Associated Glycoprotein Myelin-Oligodendrocyte Glycoprotein Myeloid cells Neurology Phenylurea Compounds - therapeutic use Protein Kinase Inhibitors - therapeutic use Spinal Cord - pathology T-Lymphocytes - drug effects Thiazoles - therapeutic use Time Factors
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