Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes)

Pharmaceutical and personal care products (PPCPs) enter aquatic environments via sewage treatment facilities and their potentially toxic effects on biota, particularly aquatic organisms, are of considerable concern. In this study, we investigated the acute toxicity of selected PPCPs on a freshwater...

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Veröffentlicht in:Journal of toxicological sciences 2009/04/01, Vol.34(2), pp.227-232
Hauptverfasser: Kim, Joon-Woo, Ishibashi, Hiroshi, Yamauchi, Ryoko, Ichikawa, Nobuhiro, Takao, Yuji, Hirano, Masashi, Koga, Minoru, Arizono, Koji
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container_end_page 232
container_issue 2
container_start_page 227
container_title Journal of toxicological sciences
container_volume 34
creator Kim, Joon-Woo
Ishibashi, Hiroshi
Yamauchi, Ryoko
Ichikawa, Nobuhiro
Takao, Yuji
Hirano, Masashi
Koga, Minoru
Arizono, Koji
description Pharmaceutical and personal care products (PPCPs) enter aquatic environments via sewage treatment facilities and their potentially toxic effects on biota, particularly aquatic organisms, are of considerable concern. In this study, we investigated the acute toxicity of selected PPCPs on a freshwater crustacean (Thamnocephalus platyurus) and a fish species (Oryzias latipes). The 24-hr median lethal concentration (LC50) values of ibuprofen, mefenamic acid, indometacin, carbamazepine, propranolol, ifenprodil, clarithromycin and triclosan for T. platyurus were estimated to be 19.59, 3.95, 16.14, > 100, 10.31, 4.43, 94.23 and 0.47 mg/l respectively. Conversely, the 96-hr LC50 values for these PPCPs were estimated at > 100, 8.04, 81.92, 45.87, 11.40, 8.71, > 100 and 0.60 mg/l for O. latipes, respectively. The toxic sensitivity of T. platyurus to these PPCPs, except for carbamazepine, was therefore higher than for O. latipes. No acute toxicity effects were associated with PPCPs, such as atenolol, disopyramide, famotidine, fluconazole, erythromycin and levofloxacin, in the two aquatic organisms at the concentrations tested in this study (> 100 mg/l). These findings may help us to understand the potential biological effects and risks associated with PPCP exposure in aquatic organisms. Further long-term studies are required to fully assess the growth and reproduction of these compounds on aquatic biota.
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subjects Acute toxicity
Animals
Anostraca - drug effects
Drug-Related Side Effects and Adverse Reactions
Freshwater
Larva - drug effects
Longevity - drug effects
Oryzias
Oryzias latipes
Pharmaceutical and personal care products
Sewage - adverse effects
Thamnocephalus platyurus
Toxicity Tests, Acute
Water Pollutants, Chemical - adverse effects
title Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes)
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