Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes)
Pharmaceutical and personal care products (PPCPs) enter aquatic environments via sewage treatment facilities and their potentially toxic effects on biota, particularly aquatic organisms, are of considerable concern. In this study, we investigated the acute toxicity of selected PPCPs on a freshwater...
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Veröffentlicht in: | Journal of toxicological sciences 2009/04/01, Vol.34(2), pp.227-232 |
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description | Pharmaceutical and personal care products (PPCPs) enter aquatic environments via sewage treatment facilities and their potentially toxic effects on biota, particularly aquatic organisms, are of considerable concern. In this study, we investigated the acute toxicity of selected PPCPs on a freshwater crustacean (Thamnocephalus platyurus) and a fish species (Oryzias latipes). The 24-hr median lethal concentration (LC50) values of ibuprofen, mefenamic acid, indometacin, carbamazepine, propranolol, ifenprodil, clarithromycin and triclosan for T. platyurus were estimated to be 19.59, 3.95, 16.14, > 100, 10.31, 4.43, 94.23 and 0.47 mg/l respectively. Conversely, the 96-hr LC50 values for these PPCPs were estimated at > 100, 8.04, 81.92, 45.87, 11.40, 8.71, > 100 and 0.60 mg/l for O. latipes, respectively. The toxic sensitivity of T. platyurus to these PPCPs, except for carbamazepine, was therefore higher than for O. latipes. No acute toxicity effects were associated with PPCPs, such as atenolol, disopyramide, famotidine, fluconazole, erythromycin and levofloxacin, in the two aquatic organisms at the concentrations tested in this study (> 100 mg/l). These findings may help us to understand the potential biological effects and risks associated with PPCP exposure in aquatic organisms. Further long-term studies are required to fully assess the growth and reproduction of these compounds on aquatic biota. |
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In this study, we investigated the acute toxicity of selected PPCPs on a freshwater crustacean (Thamnocephalus platyurus) and a fish species (Oryzias latipes). The 24-hr median lethal concentration (LC50) values of ibuprofen, mefenamic acid, indometacin, carbamazepine, propranolol, ifenprodil, clarithromycin and triclosan for T. platyurus were estimated to be 19.59, 3.95, 16.14, > 100, 10.31, 4.43, 94.23 and 0.47 mg/l respectively. Conversely, the 96-hr LC50 values for these PPCPs were estimated at > 100, 8.04, 81.92, 45.87, 11.40, 8.71, > 100 and 0.60 mg/l for O. latipes, respectively. The toxic sensitivity of T. platyurus to these PPCPs, except for carbamazepine, was therefore higher than for O. latipes. No acute toxicity effects were associated with PPCPs, such as atenolol, disopyramide, famotidine, fluconazole, erythromycin and levofloxacin, in the two aquatic organisms at the concentrations tested in this study (> 100 mg/l). These findings may help us to understand the potential biological effects and risks associated with PPCP exposure in aquatic organisms. Further long-term studies are required to fully assess the growth and reproduction of these compounds on aquatic biota.</description><identifier>ISSN: 0388-1350</identifier><identifier>EISSN: 1880-3989</identifier><identifier>DOI: 10.2131/jts.34.227</identifier><identifier>PMID: 19336980</identifier><language>eng</language><publisher>Japan: The Japanese Society of Toxicology</publisher><subject>Acute toxicity ; Animals ; Anostraca - drug effects ; Drug-Related Side Effects and Adverse Reactions ; Freshwater ; Larva - drug effects ; Longevity - drug effects ; Oryzias ; Oryzias latipes ; Pharmaceutical and personal care products ; Sewage - adverse effects ; Thamnocephalus platyurus ; Toxicity Tests, Acute ; Water Pollutants, Chemical - adverse effects</subject><ispartof>The Journal of Toxicological Sciences, 2009/04/01, Vol.34(2), pp.227-232</ispartof><rights>2009 The Japanese Society of Toxicology</rights><rights>Copyright Japan Science and Technology Agency 2009</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c629t-b676bbe78a8de523caa899e97d073aeb37d9e4759433efaf9605d3cbfdd83c193</citedby><cites>FETCH-LOGICAL-c629t-b676bbe78a8de523caa899e97d073aeb37d9e4759433efaf9605d3cbfdd83c193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19336980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Joon-Woo</creatorcontrib><creatorcontrib>Ishibashi, Hiroshi</creatorcontrib><creatorcontrib>Yamauchi, Ryoko</creatorcontrib><creatorcontrib>Ichikawa, Nobuhiro</creatorcontrib><creatorcontrib>Takao, Yuji</creatorcontrib><creatorcontrib>Hirano, Masashi</creatorcontrib><creatorcontrib>Koga, Minoru</creatorcontrib><creatorcontrib>Arizono, Koji</creatorcontrib><title>Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes)</title><title>Journal of toxicological sciences</title><addtitle>J Toxicol Sci</addtitle><description>Pharmaceutical and personal care products (PPCPs) enter aquatic environments via sewage treatment facilities and their potentially toxic effects on biota, particularly aquatic organisms, are of considerable concern. In this study, we investigated the acute toxicity of selected PPCPs on a freshwater crustacean (Thamnocephalus platyurus) and a fish species (Oryzias latipes). The 24-hr median lethal concentration (LC50) values of ibuprofen, mefenamic acid, indometacin, carbamazepine, propranolol, ifenprodil, clarithromycin and triclosan for T. platyurus were estimated to be 19.59, 3.95, 16.14, > 100, 10.31, 4.43, 94.23 and 0.47 mg/l respectively. Conversely, the 96-hr LC50 values for these PPCPs were estimated at > 100, 8.04, 81.92, 45.87, 11.40, 8.71, > 100 and 0.60 mg/l for O. latipes, respectively. The toxic sensitivity of T. platyurus to these PPCPs, except for carbamazepine, was therefore higher than for O. latipes. No acute toxicity effects were associated with PPCPs, such as atenolol, disopyramide, famotidine, fluconazole, erythromycin and levofloxacin, in the two aquatic organisms at the concentrations tested in this study (> 100 mg/l). These findings may help us to understand the potential biological effects and risks associated with PPCP exposure in aquatic organisms. Further long-term studies are required to fully assess the growth and reproduction of these compounds on aquatic biota.</description><subject>Acute toxicity</subject><subject>Animals</subject><subject>Anostraca - drug effects</subject><subject>Drug-Related Side Effects and Adverse Reactions</subject><subject>Freshwater</subject><subject>Larva - drug effects</subject><subject>Longevity - drug effects</subject><subject>Oryzias</subject><subject>Oryzias latipes</subject><subject>Pharmaceutical and personal care products</subject><subject>Sewage - adverse effects</subject><subject>Thamnocephalus platyurus</subject><subject>Toxicity Tests, Acute</subject><subject>Water Pollutants, Chemical - adverse effects</subject><issn>0388-1350</issn><issn>1880-3989</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1rFDEUhoModm298QdIQJBWmDWZzEySKylFq1DoTb0OZzJn3FlmJmM-qOtP6K9u6i4r9CYhvE8eOOcl5B1n65IL_nkbw1pU67KUL8iKK8UKoZV-SVZMKFVwUbMT8iaELWOlZHX1mpxwLUSjFVuRh0ubItLo_gx2iDvqerpswE9gMcXBwkhh7uiCPrg5Pyx4pIt3XbIxUDfT3mPY3ENET61PIeZ_MNPzuw1Ms7OYXWMKdBkh7lLOL_7p-iFs6Pmt3_0dINCcDQuGizPyqocx4NvDfUp-fvt6d_W9uLm9_nF1eVPYptSxaBvZtC1KBarDuhQWQGmNWnZMCsBWyE5jJWtdCYE99LphdSds23edEjZPfko-7r15jt8JQzTTECyOI8zoUjAlk1Jo3mTwwzNw65LPawiGV41SqqlkmalPe8p6F4LH3ix-mMDvDGfmqR-T-zGiMrmfDL8_KFM7YfcfPRSSgS97YJt3-QuPAPjcxohH1_7IymNic20GZ_EIx7yluQ</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Kim, Joon-Woo</creator><creator>Ishibashi, Hiroshi</creator><creator>Yamauchi, Ryoko</creator><creator>Ichikawa, Nobuhiro</creator><creator>Takao, Yuji</creator><creator>Hirano, Masashi</creator><creator>Koga, Minoru</creator><creator>Arizono, Koji</creator><general>The Japanese Society of Toxicology</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20090401</creationdate><title>Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes)</title><author>Kim, Joon-Woo ; Ishibashi, Hiroshi ; Yamauchi, Ryoko ; Ichikawa, Nobuhiro ; Takao, Yuji ; Hirano, Masashi ; Koga, Minoru ; Arizono, Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c629t-b676bbe78a8de523caa899e97d073aeb37d9e4759433efaf9605d3cbfdd83c193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acute toxicity</topic><topic>Animals</topic><topic>Anostraca - drug effects</topic><topic>Drug-Related Side Effects and Adverse Reactions</topic><topic>Freshwater</topic><topic>Larva - drug effects</topic><topic>Longevity - drug effects</topic><topic>Oryzias</topic><topic>Oryzias latipes</topic><topic>Pharmaceutical and personal care products</topic><topic>Sewage - adverse effects</topic><topic>Thamnocephalus platyurus</topic><topic>Toxicity Tests, Acute</topic><topic>Water Pollutants, Chemical - adverse effects</topic><toplevel>online_resources</toplevel><creatorcontrib>Kim, Joon-Woo</creatorcontrib><creatorcontrib>Ishibashi, Hiroshi</creatorcontrib><creatorcontrib>Yamauchi, Ryoko</creatorcontrib><creatorcontrib>Ichikawa, Nobuhiro</creatorcontrib><creatorcontrib>Takao, Yuji</creatorcontrib><creatorcontrib>Hirano, Masashi</creatorcontrib><creatorcontrib>Koga, Minoru</creatorcontrib><creatorcontrib>Arizono, Koji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Journal of toxicological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Joon-Woo</au><au>Ishibashi, Hiroshi</au><au>Yamauchi, Ryoko</au><au>Ichikawa, Nobuhiro</au><au>Takao, Yuji</au><au>Hirano, Masashi</au><au>Koga, Minoru</au><au>Arizono, Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes)</atitle><jtitle>Journal of toxicological sciences</jtitle><addtitle>J Toxicol Sci</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>34</volume><issue>2</issue><spage>227</spage><epage>232</epage><pages>227-232</pages><issn>0388-1350</issn><eissn>1880-3989</eissn><abstract>Pharmaceutical and personal care products (PPCPs) enter aquatic environments via sewage treatment facilities and their potentially toxic effects on biota, particularly aquatic organisms, are of considerable concern. In this study, we investigated the acute toxicity of selected PPCPs on a freshwater crustacean (Thamnocephalus platyurus) and a fish species (Oryzias latipes). The 24-hr median lethal concentration (LC50) values of ibuprofen, mefenamic acid, indometacin, carbamazepine, propranolol, ifenprodil, clarithromycin and triclosan for T. platyurus were estimated to be 19.59, 3.95, 16.14, > 100, 10.31, 4.43, 94.23 and 0.47 mg/l respectively. Conversely, the 96-hr LC50 values for these PPCPs were estimated at > 100, 8.04, 81.92, 45.87, 11.40, 8.71, > 100 and 0.60 mg/l for O. latipes, respectively. The toxic sensitivity of T. platyurus to these PPCPs, except for carbamazepine, was therefore higher than for O. latipes. No acute toxicity effects were associated with PPCPs, such as atenolol, disopyramide, famotidine, fluconazole, erythromycin and levofloxacin, in the two aquatic organisms at the concentrations tested in this study (> 100 mg/l). These findings may help us to understand the potential biological effects and risks associated with PPCP exposure in aquatic organisms. Further long-term studies are required to fully assess the growth and reproduction of these compounds on aquatic biota.</abstract><cop>Japan</cop><pub>The Japanese Society of Toxicology</pub><pmid>19336980</pmid><doi>10.2131/jts.34.227</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Acute toxicity Animals Anostraca - drug effects Drug-Related Side Effects and Adverse Reactions Freshwater Larva - drug effects Longevity - drug effects Oryzias Oryzias latipes Pharmaceutical and personal care products Sewage - adverse effects Thamnocephalus platyurus Toxicity Tests, Acute Water Pollutants, Chemical - adverse effects |
title | Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes) |
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