Platelet-activating factor acetylhydrolase: selective inhibition by potent n-alkyl methylphosphonofluoridates

Platelet-activating factor (PAF) is a potent endogenous phospholipid modulator of diverse biological activities, including inflammation and shock. PAF levels are primarily regulated by PAF acetylhydrolases (PAF-AHs). These enzymes are candidate secondary targets of organophosphorus (OP) pesticides a...

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Veröffentlicht in:	Toxicology and applied pharmacology 2005-06, Vol.205 (2), p.149-156
Hauptverfasser:	Quistad, Gary B., Fisher, Karl J., Owen, Sarah C., Klintenberg, Rebecka, Casida, John E.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Alkyl-2-acetylglycerophosphocholine Esterase - antagonists & inhibitors 1-Alkyl-2-acetylglycerophosphocholine Esterase - blood 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism Acetylhydrolase Animals Biological and medical sciences Brain - enzymology Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - toxicity Drug Synergism Humans In Vitro Techniques Liver - enzymology Male Medical sciences Methylphosphonofluoridate Mice Organ Specificity Organophosphorus Compounds - chemistry Organophosphorus Compounds - toxicity Organophosphorus inhibitor Pesticide Pesticides - chemistry Pesticides - toxicity Pesticides, fertilizers and other agrochemicals toxicology Platelet-activating factor Sarin - chemistry Sarin - toxicity Structure-Activity Relationship Substrate Specificity Testis - enzymology Toxicology Tribufos
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