Design, Synthesis and Antiproliferative Activities of Oxidative Stress Inducers Based on 2-Styryl-3,5-dihydro-4H-imidazol-4-one Scaffold

The 2-styryl-3,5-dihydro-4H-imidazol-4-one might be considered as a system with isosteric properties similar to trans-cinnamaldehyde (styrylaldehyde), a safe natural compound that exhibited interesting activities against various cancers. We synthesized a series of compounds that differ structurally...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2018/10/01, Vol.66(10), pp.967-975
Hauptverfasser:	Omar, Abdelsattar M., Abdelghany, Tamer M., Abdel-Bakky, Mohamed S., Alahdal, Abdulrahman M., Radwan, Mohamed F., El-Araby, Moustafa E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antiproliferatives Apoptosis Apoptosis - drug effects Aromatic compounds Biotechnology Breast cancer Cancer Caspase Caspase-3 Catalase Cell cycle Cell Cycle Checkpoints - drug effects Cell Line Cell Proliferation - drug effects Cinnamaldehyde Colon Colon cancer Colorectal cancer Cricetinae Cytotoxicity DNA fragmentation Dose-Response Relationship, Drug Drug Design Drug Screening Assays, Antitumor Extreme values Fibroblasts Glutathione Humans Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology imidazolone Liver cancer Lungs Malondialdehyde Molecular Structure Oxidative stress Oxidative Stress - drug effects oxidative stress marker Pharmacology Reactive oxygen species Reactive Oxygen Species - metabolism redox dysregulation selective antiproliferative Structure-Activity Relationship Superoxide dismutase Synthesis Toxicity Tumor cell lines
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