Lactic Acid Upregulates VEGF Expression in Macrophages and Facilitates Choroidal Neovascularization

Lactic acid, the end product of glycolysis, has emerged as an immune-modulating metabolite in various diseases. In this study, we aimed to examine whether lactic acid contributes to the disease pathogenesis of choroidal neovascularization (CNV) and to investigate the role of macrophages in CNV patho...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2018-07, Vol.59 (8), p.3747-3754
Hauptverfasser:	Song, Juha, Lee, Kihwang, Park, Sung Wook, Chung, Hyewon, Jung, Daun, Na, Yi Rang, Quan, Hailian, Cho, Chang Sik, Che, Jeong-Hwan, Kim, Jeong Hun, Park, Jae-Hak, Seok, Seung Hyeok
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Choroid - metabolism Choroid - pathology Choroidal Neovascularization - drug therapy Choroidal Neovascularization - genetics Choroidal Neovascularization - metabolism Choroidal Neovascularization - pathology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Gene Expression Regulation Humans Lactic Acid - pharmacology Macrophages - metabolism Mice Mice, Inbred C57BL Polymerase Chain Reaction RNA - genetics Up-Regulation Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics
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