Tablet Formulation of a Polymeric Solid Dispersion Containing Amorphous Alkalinized Telmisartan

To overcome the poor dissolution of telmisartan (TMS) at weak acidic pH, amorphous alkalinized TMS (AAT) was prepared by introducing sodium hydroxide as a selective alkalizer. AAT-containing polymeric solid dispersions were prepared by a solvent evaporation method; these solid dispersions were AAT-P...

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Veröffentlicht in:	AAPS PharmSciTech 2018-10, Vol.19 (7), p.2990-2999
Hauptverfasser:	Chae, Jun Soo, Chae, Bo Ram, Shin, Dong Jun, Goo, Yoon Tae, Lee, Eun Seok, Yoon, Ho Yub, Kim, Chang Hyun, Choi, Young Wook
Format:	Artikel
Sprache:	eng
Schlagworte:	Antacids - chemistry Antacids - metabolism Antihypertensive Agents - chemistry Antihypertensive Agents - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Calorimetry, Differential Scanning - methods Drug Compounding - methods Excipients - chemistry Excipients - metabolism Microscopy, Electron, Scanning - methods Pharmacology/Toxicology Pharmacy Polymers - chemistry Polymers - metabolism Research Article Solvents - chemistry Solvents - metabolism Spectroscopy, Fourier Transform Infrared - methods Tablets Telmisartan - chemistry Telmisartan - metabolism X-Ray Diffraction - methods
Online-Zugang:	Volltext
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