1H NMR based pharmacometabolomics analysis of metabolic phenotype on predicting metabolism characteristics of losartan in healthy volunteers

Inter-individual variability in drug metabolism and disposition is common in both preclinical and clinical researches. Losartan and its active metabolite EXP3174 present a high degree of inter-individual differences in blood concentrations that affect drug efficacy and side effect. Pharmacometabolom...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2018-09, Vol.1095, p.15-23
Hauptverfasser:	He, Chenjie, Liu, Yongbin, Wang, Yicheng, Tang, Jie, Tan, Zhirong, Li, Xi, Chen, Yao, Huang, Yuanfei, Chen, Xiaoping, Ouyang, Dongsheng, Zhou, Honghao, Peng, Jingbo
Format:	Artikel
Sprache:	eng
Schlagworte:	EXP3174 LC-MS/MS Losartan NMR Pharmacokinetics Pharmacometabolomics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!