An outbreak of severe invasive meningococcal disease due to a capsular switched Neisseria meningitidis hypervirulent strain B:cc11
The aim was to investigate an outbreak of invasive meningococcal disease (IMD) in Southern Sardinia. Epidemiological and microbiological investigations were performed. The latter included antimicrobial susceptibility testing and whole-genome sequencing (WGS). Seven individuals with severe IMD were f...
Gespeichert in:
| Veröffentlicht in: | Clinical microbiology and infection 2019-01, Vol.25 (1), p.111.e1-111.e4 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 111.e4 |
|---|---|
| container_issue | 1 |
| container_start_page | 111.e1 |
| container_title | Clinical microbiology and infection |
| container_volume | 25 |
| creator | Stefanelli, P. Fazio, C. Vacca, P. Palmieri, A. Ambrosio, L. Neri, A. Piana, A. Castiglia, P. Argiolas, F. Santus, S. Masala, L. Steri, G. Riccardo, F. Iannazzo, S. Maraglino, F.P. D'Amario, C. Rezza, G. |
| description | The aim was to investigate an outbreak of invasive meningococcal disease (IMD) in Southern Sardinia.
Epidemiological and microbiological investigations were performed. The latter included antimicrobial susceptibility testing and whole-genome sequencing (WGS).
Seven individuals with severe IMD were found to be infected with serogroup B (MenB) Neisseria meningitidis in the first quarter of 2018. Five of the seven cases (five males; mean age 19 years; range 18–21 years; CFR 40%) were due to a unique strain B:P1.5-1,10-8:F3-6:ST-11(cc11), probably switched from the hypervirulent C-cc11, as confirmed by WGS. All five patients had attended the same nightclub in the 2 weeks prior to symptom onset. Public health measures, including chemoprophylaxis of contacts and active immunization against MenB, were implemented.
We observed five IMD cases due to the same switched MenB strain. The hypervirulent B:P1.5-1,10-8:F3-6:ST-11(cc11) strain, probably switched from C-cc11, is of concern due to the observed high virulence and case fatality rates. All the patients shared the same place of probable exposure. The molecular characterization of the invasive strain allowed the outbreak to be confirmed, which was then controlled through timely public health action. |
| doi_str_mv | 10.1016/j.cmi.2018.07.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2075542906</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1198743X18305329</els_id><sourcerecordid>2075542906</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-ba60521a5628beb9fe54509b5450c5431061ac11a42c9e896f6823fce880b9b23</originalsourceid><addsrcrecordid>eNp9kD2P1DAQhi0E4j7gB9AglzQJ4484MVR3Jw6QTtCARGc5zoTzksSL7QRdyy_Hq10oaWameN5XmoeQFwxqBky93tVu9jUH1tXQ1sDkI3LOpNIVKM0el5vprmql-HZGLlLaAQAXQj4lZwJAKNWKc_L7aqFhzX1E-4OGkSbcMCL1y2aT35DOuPjle3DBOTvRwSe0CemwIs2BWursPq2TjTT98tnd40A_oU8Jo7enqM--pOj9wx7j5uM64ZJpytH6hV6_cY6xZ-TJaKeEz0_7kny9fffl5kN19_n9x5uru8pJxXPVWwUNZ7ZRvOux1yM2sgHdH6ZrpGCgmC11VnKnsdNqVB0Xo8Oug173XFySV8fefQw_V0zZzD45nCa7YFiT4dA2jeQaVEHZEXUxpBRxNPvoZxsfDANzUG92pqg3B_UGWlPUl8zLU_3azzj8S_x1XYC3RwDLk5vHaJLzuDgcfESXzRD8f-r_ALx3ldA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2075542906</pqid></control><display><type>article</type><title>An outbreak of severe invasive meningococcal disease due to a capsular switched Neisseria meningitidis hypervirulent strain B:cc11</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Stefanelli, P. ; Fazio, C. ; Vacca, P. ; Palmieri, A. ; Ambrosio, L. ; Neri, A. ; Piana, A. ; Castiglia, P. ; Argiolas, F. ; Santus, S. ; Masala, L. ; Steri, G. ; Riccardo, F. ; Iannazzo, S. ; Maraglino, F.P. ; D'Amario, C. ; Rezza, G.</creator><creatorcontrib>Stefanelli, P. ; Fazio, C. ; Vacca, P. ; Palmieri, A. ; Ambrosio, L. ; Neri, A. ; Piana, A. ; Castiglia, P. ; Argiolas, F. ; Santus, S. ; Masala, L. ; Steri, G. ; Riccardo, F. ; Iannazzo, S. ; Maraglino, F.P. ; D'Amario, C. ; Rezza, G.</creatorcontrib><description>The aim was to investigate an outbreak of invasive meningococcal disease (IMD) in Southern Sardinia.
Epidemiological and microbiological investigations were performed. The latter included antimicrobial susceptibility testing and whole-genome sequencing (WGS).
Seven individuals with severe IMD were found to be infected with serogroup B (MenB) Neisseria meningitidis in the first quarter of 2018. Five of the seven cases (five males; mean age 19 years; range 18–21 years; CFR 40%) were due to a unique strain B:P1.5-1,10-8:F3-6:ST-11(cc11), probably switched from the hypervirulent C-cc11, as confirmed by WGS. All five patients had attended the same nightclub in the 2 weeks prior to symptom onset. Public health measures, including chemoprophylaxis of contacts and active immunization against MenB, were implemented.
We observed five IMD cases due to the same switched MenB strain. The hypervirulent B:P1.5-1,10-8:F3-6:ST-11(cc11) strain, probably switched from C-cc11, is of concern due to the observed high virulence and case fatality rates. All the patients shared the same place of probable exposure. The molecular characterization of the invasive strain allowed the outbreak to be confirmed, which was then controlled through timely public health action.</description><identifier>ISSN: 1198-743X</identifier><identifier>EISSN: 1469-0691</identifier><identifier>DOI: 10.1016/j.cmi.2018.07.014</identifier><identifier>PMID: 30036673</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Anti-Bacterial Agents - therapeutic use ; Antigens, Bacterial - immunology ; Bacterial Capsules - genetics ; Bacterial Capsules - immunology ; Capsular switching ; Disease Outbreaks ; Female ; Humans ; Hypervirulent ; Invasive meningococcal disease ; Italy ; Italy - epidemiology ; Male ; Meningococcal Infections - epidemiology ; Meningococcal Infections - microbiology ; Meningococcal Infections - transmission ; Middle Aged ; Neisseria meningitides ; Neisseria meningitidis - genetics ; Neisseria meningitidis - pathogenicity ; Outbreak ; Serogroup ; Virulence ; Whole Genome Sequencing ; Young Adult</subject><ispartof>Clinical microbiology and infection, 2019-01, Vol.25 (1), p.111.e1-111.e4</ispartof><rights>2018 The Author(s)</rights><rights>Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-ba60521a5628beb9fe54509b5450c5431061ac11a42c9e896f6823fce880b9b23</citedby><cites>FETCH-LOGICAL-c462t-ba60521a5628beb9fe54509b5450c5431061ac11a42c9e896f6823fce880b9b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30036673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stefanelli, P.</creatorcontrib><creatorcontrib>Fazio, C.</creatorcontrib><creatorcontrib>Vacca, P.</creatorcontrib><creatorcontrib>Palmieri, A.</creatorcontrib><creatorcontrib>Ambrosio, L.</creatorcontrib><creatorcontrib>Neri, A.</creatorcontrib><creatorcontrib>Piana, A.</creatorcontrib><creatorcontrib>Castiglia, P.</creatorcontrib><creatorcontrib>Argiolas, F.</creatorcontrib><creatorcontrib>Santus, S.</creatorcontrib><creatorcontrib>Masala, L.</creatorcontrib><creatorcontrib>Steri, G.</creatorcontrib><creatorcontrib>Riccardo, F.</creatorcontrib><creatorcontrib>Iannazzo, S.</creatorcontrib><creatorcontrib>Maraglino, F.P.</creatorcontrib><creatorcontrib>D'Amario, C.</creatorcontrib><creatorcontrib>Rezza, G.</creatorcontrib><title>An outbreak of severe invasive meningococcal disease due to a capsular switched Neisseria meningitidis hypervirulent strain B:cc11</title><title>Clinical microbiology and infection</title><addtitle>Clin Microbiol Infect</addtitle><description>The aim was to investigate an outbreak of invasive meningococcal disease (IMD) in Southern Sardinia.
Epidemiological and microbiological investigations were performed. The latter included antimicrobial susceptibility testing and whole-genome sequencing (WGS).
Seven individuals with severe IMD were found to be infected with serogroup B (MenB) Neisseria meningitidis in the first quarter of 2018. Five of the seven cases (five males; mean age 19 years; range 18–21 years; CFR 40%) were due to a unique strain B:P1.5-1,10-8:F3-6:ST-11(cc11), probably switched from the hypervirulent C-cc11, as confirmed by WGS. All five patients had attended the same nightclub in the 2 weeks prior to symptom onset. Public health measures, including chemoprophylaxis of contacts and active immunization against MenB, were implemented.
We observed five IMD cases due to the same switched MenB strain. The hypervirulent B:P1.5-1,10-8:F3-6:ST-11(cc11) strain, probably switched from C-cc11, is of concern due to the observed high virulence and case fatality rates. All the patients shared the same place of probable exposure. The molecular characterization of the invasive strain allowed the outbreak to be confirmed, which was then controlled through timely public health action.</description><subject>Adolescent</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antigens, Bacterial - immunology</subject><subject>Bacterial Capsules - genetics</subject><subject>Bacterial Capsules - immunology</subject><subject>Capsular switching</subject><subject>Disease Outbreaks</subject><subject>Female</subject><subject>Humans</subject><subject>Hypervirulent</subject><subject>Invasive meningococcal disease</subject><subject>Italy</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Meningococcal Infections - epidemiology</subject><subject>Meningococcal Infections - microbiology</subject><subject>Meningococcal Infections - transmission</subject><subject>Middle Aged</subject><subject>Neisseria meningitides</subject><subject>Neisseria meningitidis - genetics</subject><subject>Neisseria meningitidis - pathogenicity</subject><subject>Outbreak</subject><subject>Serogroup</subject><subject>Virulence</subject><subject>Whole Genome Sequencing</subject><subject>Young Adult</subject><issn>1198-743X</issn><issn>1469-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD2P1DAQhi0E4j7gB9AglzQJ4484MVR3Jw6QTtCARGc5zoTzksSL7QRdyy_Hq10oaWameN5XmoeQFwxqBky93tVu9jUH1tXQ1sDkI3LOpNIVKM0el5vprmql-HZGLlLaAQAXQj4lZwJAKNWKc_L7aqFhzX1E-4OGkSbcMCL1y2aT35DOuPjle3DBOTvRwSe0CemwIs2BWursPq2TjTT98tnd40A_oU8Jo7enqM--pOj9wx7j5uM64ZJpytH6hV6_cY6xZ-TJaKeEz0_7kny9fffl5kN19_n9x5uru8pJxXPVWwUNZ7ZRvOux1yM2sgHdH6ZrpGCgmC11VnKnsdNqVB0Xo8Oug173XFySV8fefQw_V0zZzD45nCa7YFiT4dA2jeQaVEHZEXUxpBRxNPvoZxsfDANzUG92pqg3B_UGWlPUl8zLU_3azzj8S_x1XYC3RwDLk5vHaJLzuDgcfESXzRD8f-r_ALx3ldA</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Stefanelli, P.</creator><creator>Fazio, C.</creator><creator>Vacca, P.</creator><creator>Palmieri, A.</creator><creator>Ambrosio, L.</creator><creator>Neri, A.</creator><creator>Piana, A.</creator><creator>Castiglia, P.</creator><creator>Argiolas, F.</creator><creator>Santus, S.</creator><creator>Masala, L.</creator><creator>Steri, G.</creator><creator>Riccardo, F.</creator><creator>Iannazzo, S.</creator><creator>Maraglino, F.P.</creator><creator>D'Amario, C.</creator><creator>Rezza, G.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201901</creationdate><title>An outbreak of severe invasive meningococcal disease due to a capsular switched Neisseria meningitidis hypervirulent strain B:cc11</title><author>Stefanelli, P. ; Fazio, C. ; Vacca, P. ; Palmieri, A. ; Ambrosio, L. ; Neri, A. ; Piana, A. ; Castiglia, P. ; Argiolas, F. ; Santus, S. ; Masala, L. ; Steri, G. ; Riccardo, F. ; Iannazzo, S. ; Maraglino, F.P. ; D'Amario, C. ; Rezza, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-ba60521a5628beb9fe54509b5450c5431061ac11a42c9e896f6823fce880b9b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antigens, Bacterial - immunology</topic><topic>Bacterial Capsules - genetics</topic><topic>Bacterial Capsules - immunology</topic><topic>Capsular switching</topic><topic>Disease Outbreaks</topic><topic>Female</topic><topic>Humans</topic><topic>Hypervirulent</topic><topic>Invasive meningococcal disease</topic><topic>Italy</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Meningococcal Infections - epidemiology</topic><topic>Meningococcal Infections - microbiology</topic><topic>Meningococcal Infections - transmission</topic><topic>Middle Aged</topic><topic>Neisseria meningitides</topic><topic>Neisseria meningitidis - genetics</topic><topic>Neisseria meningitidis - pathogenicity</topic><topic>Outbreak</topic><topic>Serogroup</topic><topic>Virulence</topic><topic>Whole Genome Sequencing</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stefanelli, P.</creatorcontrib><creatorcontrib>Fazio, C.</creatorcontrib><creatorcontrib>Vacca, P.</creatorcontrib><creatorcontrib>Palmieri, A.</creatorcontrib><creatorcontrib>Ambrosio, L.</creatorcontrib><creatorcontrib>Neri, A.</creatorcontrib><creatorcontrib>Piana, A.</creatorcontrib><creatorcontrib>Castiglia, P.</creatorcontrib><creatorcontrib>Argiolas, F.</creatorcontrib><creatorcontrib>Santus, S.</creatorcontrib><creatorcontrib>Masala, L.</creatorcontrib><creatorcontrib>Steri, G.</creatorcontrib><creatorcontrib>Riccardo, F.</creatorcontrib><creatorcontrib>Iannazzo, S.</creatorcontrib><creatorcontrib>Maraglino, F.P.</creatorcontrib><creatorcontrib>D'Amario, C.</creatorcontrib><creatorcontrib>Rezza, G.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical microbiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stefanelli, P.</au><au>Fazio, C.</au><au>Vacca, P.</au><au>Palmieri, A.</au><au>Ambrosio, L.</au><au>Neri, A.</au><au>Piana, A.</au><au>Castiglia, P.</au><au>Argiolas, F.</au><au>Santus, S.</au><au>Masala, L.</au><au>Steri, G.</au><au>Riccardo, F.</au><au>Iannazzo, S.</au><au>Maraglino, F.P.</au><au>D'Amario, C.</au><au>Rezza, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An outbreak of severe invasive meningococcal disease due to a capsular switched Neisseria meningitidis hypervirulent strain B:cc11</atitle><jtitle>Clinical microbiology and infection</jtitle><addtitle>Clin Microbiol Infect</addtitle><date>2019-01</date><risdate>2019</risdate><volume>25</volume><issue>1</issue><spage>111.e1</spage><epage>111.e4</epage><pages>111.e1-111.e4</pages><issn>1198-743X</issn><eissn>1469-0691</eissn><abstract>The aim was to investigate an outbreak of invasive meningococcal disease (IMD) in Southern Sardinia.
Epidemiological and microbiological investigations were performed. The latter included antimicrobial susceptibility testing and whole-genome sequencing (WGS).
Seven individuals with severe IMD were found to be infected with serogroup B (MenB) Neisseria meningitidis in the first quarter of 2018. Five of the seven cases (five males; mean age 19 years; range 18–21 years; CFR 40%) were due to a unique strain B:P1.5-1,10-8:F3-6:ST-11(cc11), probably switched from the hypervirulent C-cc11, as confirmed by WGS. All five patients had attended the same nightclub in the 2 weeks prior to symptom onset. Public health measures, including chemoprophylaxis of contacts and active immunization against MenB, were implemented.
We observed five IMD cases due to the same switched MenB strain. The hypervirulent B:P1.5-1,10-8:F3-6:ST-11(cc11) strain, probably switched from C-cc11, is of concern due to the observed high virulence and case fatality rates. All the patients shared the same place of probable exposure. The molecular characterization of the invasive strain allowed the outbreak to be confirmed, which was then controlled through timely public health action.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30036673</pmid><doi>10.1016/j.cmi.2018.07.014</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1198-743X |
| ispartof | Clinical microbiology and infection, 2019-01, Vol.25 (1), p.111.e1-111.e4 |
| issn | 1198-743X 1469-0691 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2075542906 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Anti-Bacterial Agents - therapeutic use Antigens, Bacterial - immunology Bacterial Capsules - genetics Bacterial Capsules - immunology Capsular switching Disease Outbreaks Female Humans Hypervirulent Invasive meningococcal disease Italy Italy - epidemiology Male Meningococcal Infections - epidemiology Meningococcal Infections - microbiology Meningococcal Infections - transmission Middle Aged Neisseria meningitides Neisseria meningitidis - genetics Neisseria meningitidis - pathogenicity Outbreak Serogroup Virulence Whole Genome Sequencing Young Adult |
| title | An outbreak of severe invasive meningococcal disease due to a capsular switched Neisseria meningitidis hypervirulent strain B:cc11 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T13%3A31%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20outbreak%20of%20severe%20invasive%20meningococcal%20disease%20due%20to%20a%20capsular%20switched%20Neisseria%20meningitidis%20hypervirulent%20strain%20B:cc11&rft.jtitle=Clinical%20microbiology%20and%20infection&rft.au=Stefanelli,%20P.&rft.date=2019-01&rft.volume=25&rft.issue=1&rft.spage=111.e1&rft.epage=111.e4&rft.pages=111.e1-111.e4&rft.issn=1198-743X&rft.eissn=1469-0691&rft_id=info:doi/10.1016/j.cmi.2018.07.014&rft_dat=%3Cproquest_cross%3E2075542906%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2075542906&rft_id=info:pmid/30036673&rft_els_id=S1198743X18305329&rfr_iscdi=true |