Antimicrobial activity of leptospermone and its derivatives against human intestinal bacteria
The anaerobic growth inhibiting activity of the essential oil of Leptospermum scoparium seeds against intestinal bacteria was evaluated in vitro. The essential oil at 5.0 mg/disc strongly (+++) inhibited the growth of Clostridium difficile and Clostridium perfringens, but did not inhibit the growth...
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| Veröffentlicht in: | Food chemistry 2009-08, Vol.115 (4), p.1401-1404 |
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| creator | Jeong, Eun-Young Jeon, Ju-Hyun Kim, Hyung-Wook Kim, Min-Gi Lee, Hoi-Seon |
| description | The anaerobic growth inhibiting activity of the essential oil of
Leptospermum scoparium seeds against intestinal bacteria was evaluated
in vitro. The essential oil at 5.0
mg/disc strongly (+++) inhibited the growth of
Clostridium difficile and
Clostridium perfringens, but did not inhibit the growth of
Bifidobacterium breve,
Bifidobacterium longum,
Escherichia coli, or
Lactobacillus casei. Spectroscopic analyses revealed that the active component of the essential oil was leptospermone. Leptospermone strongly inhibited the growth of
C. difficile and
C. perfringens at 1.0
mg/disc and moderately inhibited their growth at 0.5
mg/disc. However, leptospermone did not inhibit the growth of
B. breve,
B. longum, and
L. casei. When compared with the leptospermone derivatives, 1,2,3-cyclohexanetrione-1,3-dioxime exerted strong inhibition against
C. perfringens and moderate inhibition against
C. difficile at 0.5
mg/disc, whereas the other derivatives exerted weak or no growth inhibition against all bacteria tested. Taken together, these results indicate that cyclohexanetrione is required for triketone derivatives to inhibit the growth of
C. difficile and
C. perfringens. These findings indicate that
L. scoparium seed-derived materials and 1,2,3-cyclohexanetrione-1,3-dioxime are naturally occurring antimicrobial agents that could be useful in the development of new agents for the specific control of
C. difficile and
C. perfringens. |
| doi_str_mv | 10.1016/j.foodchem.2009.01.086 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20749841</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0308814609001071</els_id><sourcerecordid>20749841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c397t-9ebe19a81b4447c8c1342f4053ad171be0d1afb8e5f60b638da14a743497f1e23</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi0EEkvbvwC5wC1hJvEmzo2q4kuqxKH0WFkTZ9x6ldiL7V2p_x6XLVw5zeWZd-Z9hHiL0CBg_3HX2BBm88Br0wKMDWADqn8hNqiGrh5gaF-KDXSgaoWyfy3epLQDgBZQbcTdpc9udSaGydFSkcnu6PJjFWy18D6HtOe4Bs8V-blyOVUzR3ekQnGq6J6cT7l6OKzkK-czp-x8iZlKTuHoXLyytCS-eJ5n4vbL559X3-rrH1-_X11e16Ybh1yPPDGOpHCSUg5GGexkayVsO5pxwIlhRrKT4q3tYeo7NRNKGmQnx8Eit92Z-HDK3cfw61C-0KtLhpeFPIdD0i0MclQSC9ifwFI4pchW76NbKT5qBP1kU-_0X5v6yaYG1MVmWXz_fIGSocVG8salf9stliLbP9y7E2cpaLqPhbm9Kaq7kl1aoSrEpxPBRcjRcdTJOPaGZxfZZD0H979nfgPPPZll</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20749841</pqid></control><display><type>article</type><title>Antimicrobial activity of leptospermone and its derivatives against human intestinal bacteria</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><creator>Jeong, Eun-Young ; Jeon, Ju-Hyun ; Kim, Hyung-Wook ; Kim, Min-Gi ; Lee, Hoi-Seon</creator><creatorcontrib>Jeong, Eun-Young ; Jeon, Ju-Hyun ; Kim, Hyung-Wook ; Kim, Min-Gi ; Lee, Hoi-Seon</creatorcontrib><description>The anaerobic growth inhibiting activity of the essential oil of
Leptospermum scoparium seeds against intestinal bacteria was evaluated
in vitro. The essential oil at 5.0
mg/disc strongly (+++) inhibited the growth of
Clostridium difficile and
Clostridium perfringens, but did not inhibit the growth of
Bifidobacterium breve,
Bifidobacterium longum,
Escherichia coli, or
Lactobacillus casei. Spectroscopic analyses revealed that the active component of the essential oil was leptospermone. Leptospermone strongly inhibited the growth of
C. difficile and
C. perfringens at 1.0
mg/disc and moderately inhibited their growth at 0.5
mg/disc. However, leptospermone did not inhibit the growth of
B. breve,
B. longum, and
L. casei. When compared with the leptospermone derivatives, 1,2,3-cyclohexanetrione-1,3-dioxime exerted strong inhibition against
C. perfringens and moderate inhibition against
C. difficile at 0.5
mg/disc, whereas the other derivatives exerted weak or no growth inhibition against all bacteria tested. Taken together, these results indicate that cyclohexanetrione is required for triketone derivatives to inhibit the growth of
C. difficile and
C. perfringens. These findings indicate that
L. scoparium seed-derived materials and 1,2,3-cyclohexanetrione-1,3-dioxime are naturally occurring antimicrobial agents that could be useful in the development of new agents for the specific control of
C. difficile and
C. perfringens.</description><identifier>ISSN: 0308-8146</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2009.01.086</identifier><identifier>CODEN: FOCHDJ</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>1,2,3-cyclohexanetrione-1,3-dioxime ; antibacterial properties ; Bifidobacterium breve ; Bifidobacterium longum ; Biological and medical sciences ; chemical composition ; Clostridium difficile ; Clostridium perfringens ; cyclohexanetrione ; Escherichia coli ; essential oils ; Food industries ; Food microbiology ; Fundamental and applied biological sciences. Psychology ; Intestinal bacteria ; intestinal microorganisms ; Lactobacillus casei ; Leptospermone ; leptospermone derivatives ; Leptospermum scoparium ; microbial growth ; seeds ; species differences ; triketone derivatives</subject><ispartof>Food chemistry, 2009-08, Vol.115 (4), p.1401-1404</ispartof><rights>2009 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-9ebe19a81b4447c8c1342f4053ad171be0d1afb8e5f60b638da14a743497f1e23</citedby><cites>FETCH-LOGICAL-c397t-9ebe19a81b4447c8c1342f4053ad171be0d1afb8e5f60b638da14a743497f1e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foodchem.2009.01.086$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21397586$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeong, Eun-Young</creatorcontrib><creatorcontrib>Jeon, Ju-Hyun</creatorcontrib><creatorcontrib>Kim, Hyung-Wook</creatorcontrib><creatorcontrib>Kim, Min-Gi</creatorcontrib><creatorcontrib>Lee, Hoi-Seon</creatorcontrib><title>Antimicrobial activity of leptospermone and its derivatives against human intestinal bacteria</title><title>Food chemistry</title><description>The anaerobic growth inhibiting activity of the essential oil of
Leptospermum scoparium seeds against intestinal bacteria was evaluated
in vitro. The essential oil at 5.0
mg/disc strongly (+++) inhibited the growth of
Clostridium difficile and
Clostridium perfringens, but did not inhibit the growth of
Bifidobacterium breve,
Bifidobacterium longum,
Escherichia coli, or
Lactobacillus casei. Spectroscopic analyses revealed that the active component of the essential oil was leptospermone. Leptospermone strongly inhibited the growth of
C. difficile and
C. perfringens at 1.0
mg/disc and moderately inhibited their growth at 0.5
mg/disc. However, leptospermone did not inhibit the growth of
B. breve,
B. longum, and
L. casei. When compared with the leptospermone derivatives, 1,2,3-cyclohexanetrione-1,3-dioxime exerted strong inhibition against
C. perfringens and moderate inhibition against
C. difficile at 0.5
mg/disc, whereas the other derivatives exerted weak or no growth inhibition against all bacteria tested. Taken together, these results indicate that cyclohexanetrione is required for triketone derivatives to inhibit the growth of
C. difficile and
C. perfringens. These findings indicate that
L. scoparium seed-derived materials and 1,2,3-cyclohexanetrione-1,3-dioxime are naturally occurring antimicrobial agents that could be useful in the development of new agents for the specific control of
C. difficile and
C. perfringens.</description><subject>1,2,3-cyclohexanetrione-1,3-dioxime</subject><subject>antibacterial properties</subject><subject>Bifidobacterium breve</subject><subject>Bifidobacterium longum</subject><subject>Biological and medical sciences</subject><subject>chemical composition</subject><subject>Clostridium difficile</subject><subject>Clostridium perfringens</subject><subject>cyclohexanetrione</subject><subject>Escherichia coli</subject><subject>essential oils</subject><subject>Food industries</subject><subject>Food microbiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Intestinal bacteria</subject><subject>intestinal microorganisms</subject><subject>Lactobacillus casei</subject><subject>Leptospermone</subject><subject>leptospermone derivatives</subject><subject>Leptospermum scoparium</subject><subject>microbial growth</subject><subject>seeds</subject><subject>species differences</subject><subject>triketone derivatives</subject><issn>0308-8146</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v1DAQhi0EEkvbvwC5wC1hJvEmzo2q4kuqxKH0WFkTZ9x6ldiL7V2p_x6XLVw5zeWZd-Z9hHiL0CBg_3HX2BBm88Br0wKMDWADqn8hNqiGrh5gaF-KDXSgaoWyfy3epLQDgBZQbcTdpc9udSaGydFSkcnu6PJjFWy18D6HtOe4Bs8V-blyOVUzR3ekQnGq6J6cT7l6OKzkK-czp-x8iZlKTuHoXLyytCS-eJ5n4vbL559X3-rrH1-_X11e16Ybh1yPPDGOpHCSUg5GGexkayVsO5pxwIlhRrKT4q3tYeo7NRNKGmQnx8Eit92Z-HDK3cfw61C-0KtLhpeFPIdD0i0MclQSC9ifwFI4pchW76NbKT5qBP1kU-_0X5v6yaYG1MVmWXz_fIGSocVG8salf9stliLbP9y7E2cpaLqPhbm9Kaq7kl1aoSrEpxPBRcjRcdTJOPaGZxfZZD0H979nfgPPPZll</recordid><startdate>20090815</startdate><enddate>20090815</enddate><creator>Jeong, Eun-Young</creator><creator>Jeon, Ju-Hyun</creator><creator>Kim, Hyung-Wook</creator><creator>Kim, Min-Gi</creator><creator>Lee, Hoi-Seon</creator><general>Elsevier Ltd</general><general>[Amsterdam]: Elsevier Science</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20090815</creationdate><title>Antimicrobial activity of leptospermone and its derivatives against human intestinal bacteria</title><author>Jeong, Eun-Young ; Jeon, Ju-Hyun ; Kim, Hyung-Wook ; Kim, Min-Gi ; Lee, Hoi-Seon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-9ebe19a81b4447c8c1342f4053ad171be0d1afb8e5f60b638da14a743497f1e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>1,2,3-cyclohexanetrione-1,3-dioxime</topic><topic>antibacterial properties</topic><topic>Bifidobacterium breve</topic><topic>Bifidobacterium longum</topic><topic>Biological and medical sciences</topic><topic>chemical composition</topic><topic>Clostridium difficile</topic><topic>Clostridium perfringens</topic><topic>cyclohexanetrione</topic><topic>Escherichia coli</topic><topic>essential oils</topic><topic>Food industries</topic><topic>Food microbiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Intestinal bacteria</topic><topic>intestinal microorganisms</topic><topic>Lactobacillus casei</topic><topic>Leptospermone</topic><topic>leptospermone derivatives</topic><topic>Leptospermum scoparium</topic><topic>microbial growth</topic><topic>seeds</topic><topic>species differences</topic><topic>triketone derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeong, Eun-Young</creatorcontrib><creatorcontrib>Jeon, Ju-Hyun</creatorcontrib><creatorcontrib>Kim, Hyung-Wook</creatorcontrib><creatorcontrib>Kim, Min-Gi</creatorcontrib><creatorcontrib>Lee, Hoi-Seon</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeong, Eun-Young</au><au>Jeon, Ju-Hyun</au><au>Kim, Hyung-Wook</au><au>Kim, Min-Gi</au><au>Lee, Hoi-Seon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial activity of leptospermone and its derivatives against human intestinal bacteria</atitle><jtitle>Food chemistry</jtitle><date>2009-08-15</date><risdate>2009</risdate><volume>115</volume><issue>4</issue><spage>1401</spage><epage>1404</epage><pages>1401-1404</pages><issn>0308-8146</issn><eissn>1873-7072</eissn><coden>FOCHDJ</coden><abstract>The anaerobic growth inhibiting activity of the essential oil of
Leptospermum scoparium seeds against intestinal bacteria was evaluated
in vitro. The essential oil at 5.0
mg/disc strongly (+++) inhibited the growth of
Clostridium difficile and
Clostridium perfringens, but did not inhibit the growth of
Bifidobacterium breve,
Bifidobacterium longum,
Escherichia coli, or
Lactobacillus casei. Spectroscopic analyses revealed that the active component of the essential oil was leptospermone. Leptospermone strongly inhibited the growth of
C. difficile and
C. perfringens at 1.0
mg/disc and moderately inhibited their growth at 0.5
mg/disc. However, leptospermone did not inhibit the growth of
B. breve,
B. longum, and
L. casei. When compared with the leptospermone derivatives, 1,2,3-cyclohexanetrione-1,3-dioxime exerted strong inhibition against
C. perfringens and moderate inhibition against
C. difficile at 0.5
mg/disc, whereas the other derivatives exerted weak or no growth inhibition against all bacteria tested. Taken together, these results indicate that cyclohexanetrione is required for triketone derivatives to inhibit the growth of
C. difficile and
C. perfringens. These findings indicate that
L. scoparium seed-derived materials and 1,2,3-cyclohexanetrione-1,3-dioxime are naturally occurring antimicrobial agents that could be useful in the development of new agents for the specific control of
C. difficile and
C. perfringens.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.foodchem.2009.01.086</doi><tpages>4</tpages></addata></record> |
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| ispartof | Food chemistry, 2009-08, Vol.115 (4), p.1401-1404 |
| issn | 0308-8146 1873-7072 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings |
| subjects | 1,2,3-cyclohexanetrione-1,3-dioxime antibacterial properties Bifidobacterium breve Bifidobacterium longum Biological and medical sciences chemical composition Clostridium difficile Clostridium perfringens cyclohexanetrione Escherichia coli essential oils Food industries Food microbiology Fundamental and applied biological sciences. Psychology Intestinal bacteria intestinal microorganisms Lactobacillus casei Leptospermone leptospermone derivatives Leptospermum scoparium microbial growth seeds species differences triketone derivatives |
| title | Antimicrobial activity of leptospermone and its derivatives against human intestinal bacteria |
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