Nutritional status, the development and persistence of malnutrition and dietary intake in oesophago‐gastric cancer: a longitudinal cohort study
Background Patients with oesophago‐gastric (OG) cancer may be at risk of malnutrition, troublesome gastrointestinal symptoms (GI) and reduced dietary intake in view of the tumour location and multimodality curative treatment approach. Longitudinal research is lacking. The present study aimed to asse...
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Veröffentlicht in: | Journal of human nutrition and dietetics 2018-12, Vol.31 (6), p.785-792 |
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description | Background
Patients with oesophago‐gastric (OG) cancer may be at risk of malnutrition, troublesome gastrointestinal symptoms (GI) and reduced dietary intake in view of the tumour location and multimodality curative treatment approach. Longitudinal research is lacking. The present study aimed to assess (i) nutritional status and how it evolved over the first year; (ii) the association between nutritional status scores and GI symptom scores; and (iii) the nutrient and food group intake pattern.
Methods
This was a prospective, observational study of patients with an OG lesion planned for radical treatment, with assessment at diagnosis, 3 months and 12 months after the start of treatment. Nutritional assessment was performed using the Patient‐Generated Subjective Global Assessment, GI symptoms measured using the modified Gastrointestinal Symptom Rating Scale and dietary intake assessed using a semi‐quantitative food frequency approach.
Results
Eighty patients (61 males, 19 females; aged 46–89 years) were recruited. At baseline, 3 (n = 68) and 12 months (n = 57), 61%, 62% and 60%, respectively, were moderately/severely malnourished. Higher symptom burden was associated with poorer nutritional status at baseline (r = 0.55, P |
doi_str_mv | 10.1111/jhn.12588 |
format | Article |
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Patients with oesophago‐gastric (OG) cancer may be at risk of malnutrition, troublesome gastrointestinal symptoms (GI) and reduced dietary intake in view of the tumour location and multimodality curative treatment approach. Longitudinal research is lacking. The present study aimed to assess (i) nutritional status and how it evolved over the first year; (ii) the association between nutritional status scores and GI symptom scores; and (iii) the nutrient and food group intake pattern.
Methods
This was a prospective, observational study of patients with an OG lesion planned for radical treatment, with assessment at diagnosis, 3 months and 12 months after the start of treatment. Nutritional assessment was performed using the Patient‐Generated Subjective Global Assessment, GI symptoms measured using the modified Gastrointestinal Symptom Rating Scale and dietary intake assessed using a semi‐quantitative food frequency approach.
Results
Eighty patients (61 males, 19 females; aged 46–89 years) were recruited. At baseline, 3 (n = 68) and 12 months (n = 57), 61%, 62% and 60%, respectively, were moderately/severely malnourished. Higher symptom burden was associated with poorer nutritional status at baseline (r = 0.55, P < 0.001), 3 months (r = 0.51, P < 0.001) and 12 months (r = 0.42, P = 0.001). At each respective time point, 37%, 38% and 42% were meeting their estimated average requirement for energy. No change in mean (SD) intake of energy, fibre, nutrient and food groups was observed over time.
Conclusions
Patients with OG cancer have progressive weight loss, with malnutrition present over the majority of the 12‐month study period. Optimising nutritional status and symptom management throughout the treatment pathway should be a clinical priority.</description><identifier>ISSN: 0952-3871</identifier><identifier>EISSN: 1365-277X</identifier><identifier>DOI: 10.1111/jhn.12588</identifier><identifier>PMID: 30033545</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Body weight loss ; Cancer ; Cohort analysis ; Diet ; Dietary intake ; Food ; Food groups ; Food intake ; gastric ; Gastric cancer ; gastrointestinal ; Gastrointestinal symptoms ; Malnutrition ; Nutrient status ; Nutrition assessment ; Nutritional status ; Observational studies ; oesophageal ; Patients ; Symptom management ; Tumors ; undernutrition ; Weight loss</subject><ispartof>Journal of human nutrition and dietetics, 2018-12, Vol.31 (6), p.785-792</ispartof><rights>2018 The British Dietetic Association Ltd.</rights><rights>2018 The British Dietetic Association Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3888-b57d225c41584de39de426fca86e6599a267ab824d804df3f6d612fde81b92c83</citedby><cites>FETCH-LOGICAL-c3888-b57d225c41584de39de426fca86e6599a267ab824d804df3f6d612fde81b92c83</cites><orcidid>0000-0001-5414-2950 ; 0000-0002-8707-4699</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjhn.12588$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjhn.12588$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30033545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grace, E. M.</creatorcontrib><creatorcontrib>Shaw, C.</creatorcontrib><creatorcontrib>Lalji, A.</creatorcontrib><creatorcontrib>Mohammed, K.</creatorcontrib><creatorcontrib>Andreyev, H. J. N.</creatorcontrib><creatorcontrib>Whelan, K.</creatorcontrib><title>Nutritional status, the development and persistence of malnutrition and dietary intake in oesophago‐gastric cancer: a longitudinal cohort study</title><title>Journal of human nutrition and dietetics</title><addtitle>J Hum Nutr Diet</addtitle><description>Background
Patients with oesophago‐gastric (OG) cancer may be at risk of malnutrition, troublesome gastrointestinal symptoms (GI) and reduced dietary intake in view of the tumour location and multimodality curative treatment approach. Longitudinal research is lacking. The present study aimed to assess (i) nutritional status and how it evolved over the first year; (ii) the association between nutritional status scores and GI symptom scores; and (iii) the nutrient and food group intake pattern.
Methods
This was a prospective, observational study of patients with an OG lesion planned for radical treatment, with assessment at diagnosis, 3 months and 12 months after the start of treatment. Nutritional assessment was performed using the Patient‐Generated Subjective Global Assessment, GI symptoms measured using the modified Gastrointestinal Symptom Rating Scale and dietary intake assessed using a semi‐quantitative food frequency approach.
Results
Eighty patients (61 males, 19 females; aged 46–89 years) were recruited. At baseline, 3 (n = 68) and 12 months (n = 57), 61%, 62% and 60%, respectively, were moderately/severely malnourished. Higher symptom burden was associated with poorer nutritional status at baseline (r = 0.55, P < 0.001), 3 months (r = 0.51, P < 0.001) and 12 months (r = 0.42, P = 0.001). At each respective time point, 37%, 38% and 42% were meeting their estimated average requirement for energy. No change in mean (SD) intake of energy, fibre, nutrient and food groups was observed over time.
Conclusions
Patients with OG cancer have progressive weight loss, with malnutrition present over the majority of the 12‐month study period. Optimising nutritional status and symptom management throughout the treatment pathway should be a clinical priority.</description><subject>Body weight loss</subject><subject>Cancer</subject><subject>Cohort analysis</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Food</subject><subject>Food groups</subject><subject>Food intake</subject><subject>gastric</subject><subject>Gastric cancer</subject><subject>gastrointestinal</subject><subject>Gastrointestinal symptoms</subject><subject>Malnutrition</subject><subject>Nutrient status</subject><subject>Nutrition assessment</subject><subject>Nutritional status</subject><subject>Observational studies</subject><subject>oesophageal</subject><subject>Patients</subject><subject>Symptom management</subject><subject>Tumors</subject><subject>undernutrition</subject><subject>Weight loss</subject><issn>0952-3871</issn><issn>1365-277X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc9u1DAQxi1URJfCoS9QWeqlSKT138ThVlVAQVW5gMQt8tqTXS-JHWwHtDceAV6RJ8Httj0gdS7fYX7zzWg-hA4pOaWlzjZrf0qZVOoJWlBey4o1zdc9tCCtZBVXDd1Hz1PaEEJqSsgztM8J4VwKuUB_ruccXXbB6wGnrPOcXuO8BmzhBwxhGsFnrL3FE8TkUgZvAIcej3rw95O3fesg67jFzmf9DYrgAClMa70Kf3_9XulUYIONLvPxDdZ4CH7l8mzdzWIT1iHmsn-22xfoaa-HBC_v9AB9eff288VldfXp_YeL86vKcKVUtZSNZUwaQaUSFnhrQbC6N1rVUMu21axu9FIxYRURtud9bWvKeguKLltmFD9AJzvfKYbvM6TcjS4ZGAbtIcypY6QRlAvV8oIe_4duwhzL4YWinIvyzaYp1KsdZWJIKULfTdGN5ScdJd1NTl3JqbvNqbBHd47zcgT7QN4HU4CzHfDTDbB93Kn7eHm9s_wHnIugRA</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Grace, E. M.</creator><creator>Shaw, C.</creator><creator>Lalji, A.</creator><creator>Mohammed, K.</creator><creator>Andreyev, H. J. N.</creator><creator>Whelan, K.</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5414-2950</orcidid><orcidid>https://orcid.org/0000-0002-8707-4699</orcidid></search><sort><creationdate>201812</creationdate><title>Nutritional status, the development and persistence of malnutrition and dietary intake in oesophago‐gastric cancer: a longitudinal cohort study</title><author>Grace, E. M. ; Shaw, C. ; Lalji, A. ; Mohammed, K. ; Andreyev, H. J. N. ; Whelan, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3888-b57d225c41584de39de426fca86e6599a267ab824d804df3f6d612fde81b92c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Body weight loss</topic><topic>Cancer</topic><topic>Cohort analysis</topic><topic>Diet</topic><topic>Dietary intake</topic><topic>Food</topic><topic>Food groups</topic><topic>Food intake</topic><topic>gastric</topic><topic>Gastric cancer</topic><topic>gastrointestinal</topic><topic>Gastrointestinal symptoms</topic><topic>Malnutrition</topic><topic>Nutrient status</topic><topic>Nutrition assessment</topic><topic>Nutritional status</topic><topic>Observational studies</topic><topic>oesophageal</topic><topic>Patients</topic><topic>Symptom management</topic><topic>Tumors</topic><topic>undernutrition</topic><topic>Weight loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grace, E. M.</creatorcontrib><creatorcontrib>Shaw, C.</creatorcontrib><creatorcontrib>Lalji, A.</creatorcontrib><creatorcontrib>Mohammed, K.</creatorcontrib><creatorcontrib>Andreyev, H. J. N.</creatorcontrib><creatorcontrib>Whelan, K.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human nutrition and dietetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grace, E. M.</au><au>Shaw, C.</au><au>Lalji, A.</au><au>Mohammed, K.</au><au>Andreyev, H. J. N.</au><au>Whelan, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nutritional status, the development and persistence of malnutrition and dietary intake in oesophago‐gastric cancer: a longitudinal cohort study</atitle><jtitle>Journal of human nutrition and dietetics</jtitle><addtitle>J Hum Nutr Diet</addtitle><date>2018-12</date><risdate>2018</risdate><volume>31</volume><issue>6</issue><spage>785</spage><epage>792</epage><pages>785-792</pages><issn>0952-3871</issn><eissn>1365-277X</eissn><abstract>Background
Patients with oesophago‐gastric (OG) cancer may be at risk of malnutrition, troublesome gastrointestinal symptoms (GI) and reduced dietary intake in view of the tumour location and multimodality curative treatment approach. Longitudinal research is lacking. The present study aimed to assess (i) nutritional status and how it evolved over the first year; (ii) the association between nutritional status scores and GI symptom scores; and (iii) the nutrient and food group intake pattern.
Methods
This was a prospective, observational study of patients with an OG lesion planned for radical treatment, with assessment at diagnosis, 3 months and 12 months after the start of treatment. Nutritional assessment was performed using the Patient‐Generated Subjective Global Assessment, GI symptoms measured using the modified Gastrointestinal Symptom Rating Scale and dietary intake assessed using a semi‐quantitative food frequency approach.
Results
Eighty patients (61 males, 19 females; aged 46–89 years) were recruited. At baseline, 3 (n = 68) and 12 months (n = 57), 61%, 62% and 60%, respectively, were moderately/severely malnourished. Higher symptom burden was associated with poorer nutritional status at baseline (r = 0.55, P < 0.001), 3 months (r = 0.51, P < 0.001) and 12 months (r = 0.42, P = 0.001). At each respective time point, 37%, 38% and 42% were meeting their estimated average requirement for energy. No change in mean (SD) intake of energy, fibre, nutrient and food groups was observed over time.
Conclusions
Patients with OG cancer have progressive weight loss, with malnutrition present over the majority of the 12‐month study period. Optimising nutritional status and symptom management throughout the treatment pathway should be a clinical priority.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>30033545</pmid><doi>10.1111/jhn.12588</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5414-2950</orcidid><orcidid>https://orcid.org/0000-0002-8707-4699</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Body weight loss Cancer Cohort analysis Diet Dietary intake Food Food groups Food intake gastric Gastric cancer gastrointestinal Gastrointestinal symptoms Malnutrition Nutrient status Nutrition assessment Nutritional status Observational studies oesophageal Patients Symptom management Tumors undernutrition Weight loss |
title | Nutritional status, the development and persistence of malnutrition and dietary intake in oesophago‐gastric cancer: a longitudinal cohort study |
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