Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma

To test the hypothesis that aberrations of DNA repair contribute to susceptibility for the progression of gastroesophageal reflux disease (GERD) into Barrett esophagus (BE) and esophageal adenocarcinoma (EADC), we studied the frequency of polymorphisms of selected DNA repair genes in patients with G...

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Veröffentlicht in:	Carcinogenesis (New York) 2005-09, Vol.26 (9), p.1536-1541
Hauptverfasser:	Casson, Alan G., Zheng, Zuoyu, Evans, Susan C., Veugelers, Paul J., Porter, Geoffrey A., Guernsey, Duane L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adult Alcohol Drinking Barrett esophagus Barrett Esophagus - genetics base excision repair Base Sequence BER Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Case-Control Studies confidence interval DNA Primers DNA Repair - genetics DNA-Binding Proteins - genetics EADC esophageal adenocarcinoma Esophageal Neoplasms - genetics Female gastroesophageal reflux disease GERD Humans Life Style Male Medical sciences microsatellite instability Middle Aged mismatch repair MMR MSI NER nucleotide excision repair odds ratio PAT PCR poly(AT) polymerase chain reaction Polymorphism, Genetic Reference Values Risk Factors Smoking Tumors X-ray Repair Cross Complementing Protein 1 X-ray repair cross-complementing genes xeroderma pigmentosum group genes XPG genes XRCC genes
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