A Feedback Loop in the Polo-like Kinase Activation Pathway

The Xenopus polo-like kinase Plx1 plays important roles during entry into and exit from mitosis (M phase). Previous studies revealed that Plx1 is activated by phosphorylation on serine and threonine residues, and purification of an activating enzyme from mitotic Xenopus egg extracts led to cloning a...

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Veröffentlicht in:	The Journal of biological chemistry 2004-07, Vol.279 (31), p.32219-32224
Hauptverfasser:	Erikson, Eleanor, Haystead, Timothy A J, Qian, Yue-Wei, Maller, James L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - chemistry Animals Cell Cycle Proteins Cloning, Molecular DNA, Complementary - metabolism Electrophoresis, Polyacrylamide Gel Enzyme Activation Feedback, Physiological G2 Phase Immunoblotting Mitosis Mutagenesis Mutation Oocytes - metabolism Phosphorylation Polo-Like Kinase 1 Protein Kinases - metabolism Protein Serine-Threonine Kinases Proto-Oncogene Proteins Recombinant Proteins - chemistry Time Factors Xenopus Xenopus laevis
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