A Coiled‐Coil Domain Containing 50 Splice Variant Is Modulated by Serine/Arginine‐Rich Splicing Factor 3 and Promotes Hepatocellular Carcinoma in Mice by the Ras Signaling Pathway

Deregulation of alternative splicing contributes to the malignant progression of cancer. Little is known about the significant alternative splicing events in hepatocellular carcinoma (HCC). High‐throughput sequencing revealed that coiled‐coil domain containing 50 (CCDC50) pre‐mRNA is aberrantly spli...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2019-01, Vol.69 (1), p.179-195
Hauptverfasser:	Wang, Hong, Zhang, Chris Zhiyi, Lu, Shi‐Xun, Zhang, Mei‐Fang, Liu, Li‐Li, Luo, Rong‐Zhen, Yang, Xia, Wang, Chun‐Hua, Chen, Shi‐Lu, He, Yang‐Fan, Xie, Dan, Xu, Rui‐Hua, Yun, Jing‐Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Animals Arginine Carcinoma, Hepatocellular - etiology Cytoplasm Extracellular signal-regulated kinase Forkhead protein FOXO4 protein Gene expression HBX protein Hepatitis B Hepatocellular carcinoma Hepatology Kinases Liver cancer Liver Neoplasms - etiology Male Metastases Metastasis Mice Mice, Inbred BALB C mRNA stability Phenotypes Phosphorylation Protein kinase Proteins Proto-Oncogene Proteins p21(ras) - physiology Ras protein Serine Serine-Arginine Splicing Factors - physiology Signal transduction Signal Transduction - physiology Solid tumors Splicing factors Therapeutic applications Tumors
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