Wisteria floribunda agglutinin‐positive Mac‐2 binding protein predicts early occurrence of hepatocellular carcinoma after sustained virologic response by direct‐acting antivirals for hepatitis C virus
Aim The aim of this study is to clarify the value of serum Wisteria floribunda agglutinin‐positive Mac‐2 binding protein (WFA+‐M2BP) for predicting hepatocellular carcinoma (HCC) in chronic hepatitis C patients who achieved sustained virologic response (SVR) by therapy with interferon‐free, direct‐a...
Gespeichert in:
| Veröffentlicht in: | Hepatology research 2018-12, Vol.48 (13), p.1131-1139 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1139 |
|---|---|
| container_issue | 13 |
| container_start_page | 1131 |
| container_title | Hepatology research |
| container_volume | 48 |
| creator | Yasui, Yutaka Kurosaki, Masayuki Komiyama, Yasuyuki Takada, Hitomi Tamaki, Nobuharu Watakabe, Keiya Okada, Mao Wang, Wan Shimizu, Takao Kubota, Yohei Higuchi, Mayu Takaura, Kenta Tsuchiya, Kaoru Nakanishi, Hiroyuki Takahashi, Yuka Itakura, Jun Enomoto, Nobuyuki Izumi, Namiki |
| description | Aim
The aim of this study is to clarify the value of serum Wisteria floribunda agglutinin‐positive Mac‐2 binding protein (WFA+‐M2BP) for predicting hepatocellular carcinoma (HCC) in chronic hepatitis C patients who achieved sustained virologic response (SVR) by therapy with interferon‐free, direct‐acting antivirals (DAAs).
Methods
This is a retrospective cohort study that included 567 patients who underwent antiviral therapy with an interferon‐free DAA regimen and achieved SVR. Serum WFA+‐M2BP was measured after SVR. Factors predictive of HCC occurrence and recurrence were analyzed in the patients after stratification by previous treatment history of HCC.
Results
Among 518 patients who had no history of HCC, 13 developed HCC. Post‐SVR WFA+‐M2BP ≥1.75 cut‐off index (C.O.I., P |
| doi_str_mv | 10.1111/hepr.13233 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2073323287</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2158394851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4473-fa3334c5ca0b36174d53867e17de5f96697c8bcd022b157dd6d8f723643f39213</originalsourceid><addsrcrecordid>eNp9kU2KFTEUhQtR7B-duAAJOBGh2vxUVeoN5dHaQosiis6KVHLzvE29pMxPy5u5BFfWi3AlpqzWgQMzuQn5OOckp6oeMXrGynr-BeZwxgQX4k51zHrJayqaz3fLXvRd3YmmO6pOYryilEnKm_vVkaBU0AIeVzefMCYIqIidfMAxO6OI2u2mnNCh-_n9x-wjJrwG8kbpcuRkRGfQ7cgcfAJ0ZYJBnSIBFaYD8VrnEMBpIN6Skk0lr2Ga8qQC0SpodH5fPGyxJTHHpNCBIdcY_OR3qEmAOHsXgYwHYjCATsVW6bR4KleiYFBTJNaHVb2ki2S7COT4oLpnyyU8vJ2n1ceX5x-2F_Xl21evty8ua900UtRWCSEa3WpFR9Ex2Zi2fJUEJg20dtN1G6n7URvK-chaaUxneiu56BphxYYzcVo9XXXLJ3zNENOwx7i8UjnwOQ6cSlEK4b0s6JN_0CufgyvpBs7aXmyavl0En62UDj7GAHaYA-5VOAyMDkvLw9Ly8LvlAj--lczjHsxf9E-tBWAr8A0nOPxHarg4f_d-Ff0F27i6nw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2158394851</pqid></control><display><type>article</type><title>Wisteria floribunda agglutinin‐positive Mac‐2 binding protein predicts early occurrence of hepatocellular carcinoma after sustained virologic response by direct‐acting antivirals for hepatitis C virus</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Yasui, Yutaka ; Kurosaki, Masayuki ; Komiyama, Yasuyuki ; Takada, Hitomi ; Tamaki, Nobuharu ; Watakabe, Keiya ; Okada, Mao ; Wang, Wan ; Shimizu, Takao ; Kubota, Yohei ; Higuchi, Mayu ; Takaura, Kenta ; Tsuchiya, Kaoru ; Nakanishi, Hiroyuki ; Takahashi, Yuka ; Itakura, Jun ; Enomoto, Nobuyuki ; Izumi, Namiki</creator><creatorcontrib>Yasui, Yutaka ; Kurosaki, Masayuki ; Komiyama, Yasuyuki ; Takada, Hitomi ; Tamaki, Nobuharu ; Watakabe, Keiya ; Okada, Mao ; Wang, Wan ; Shimizu, Takao ; Kubota, Yohei ; Higuchi, Mayu ; Takaura, Kenta ; Tsuchiya, Kaoru ; Nakanishi, Hiroyuki ; Takahashi, Yuka ; Itakura, Jun ; Enomoto, Nobuyuki ; Izumi, Namiki</creatorcontrib><description>Aim
The aim of this study is to clarify the value of serum Wisteria floribunda agglutinin‐positive Mac‐2 binding protein (WFA+‐M2BP) for predicting hepatocellular carcinoma (HCC) in chronic hepatitis C patients who achieved sustained virologic response (SVR) by therapy with interferon‐free, direct‐acting antivirals (DAAs).
Methods
This is a retrospective cohort study that included 567 patients who underwent antiviral therapy with an interferon‐free DAA regimen and achieved SVR. Serum WFA+‐M2BP was measured after SVR. Factors predictive of HCC occurrence and recurrence were analyzed in the patients after stratification by previous treatment history of HCC.
Results
Among 518 patients who had no history of HCC, 13 developed HCC. Post‐SVR WFA+‐M2BP ≥1.75 cut‐off index (C.O.I., P < 0.001) and α‐fetoprotein (AFP) level ≥6 ng/mL (P = 0.01) were significant predictors of HCC development. Multivariate analysis showed that post‐SVR WFA+‐M2BP ≥1.75 C.O.I. was an independent factor significantly associated with the development of HCC (hazard ratio [HR] 6.0; 95% confidence interval (CI), 1.8–19.4; P = 0.003). Among 49 patients who had a previous history of HCC, 22 had recurrence after SVR. Post‐SVR AFP ≥6 ng/mL was the only factor associated with recurrence‐free survival (HR 3.1; 95% CI, 1.3–7.5; P = 0.01).
Conclusions
Post‐SVR WFA+‐M2BP is a predictive factor for the development of HCC in patients with no previous HCC history and treated with DAAs. Post‐SVR AFP was predictive for HCC recurrence after DAA therapy.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1111/hepr.13233</identifier><identifier>PMID: 30030872</identifier><language>eng</language><publisher>Netherlands: Wiley Subscription Services, Inc</publisher><subject>alpha‐fetoprotein ; Antiviral agents ; chronic hepatitis C ; Hepatitis ; Hepatitis C ; Hepatocellular carcinoma ; Interferon ; Liver cancer ; Multivariate analysis ; Patients ; Wisteria floribunda ; Wisteria floribunda agglutinin‐positive Mac‐2 binding protein</subject><ispartof>Hepatology research, 2018-12, Vol.48 (13), p.1131-1139</ispartof><rights>2018 The Japan Society of Hepatology</rights><rights>2018 The Japan Society of Hepatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4473-fa3334c5ca0b36174d53867e17de5f96697c8bcd022b157dd6d8f723643f39213</citedby><cites>FETCH-LOGICAL-c4473-fa3334c5ca0b36174d53867e17de5f96697c8bcd022b157dd6d8f723643f39213</cites><orcidid>0000-0002-6117-4990</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhepr.13233$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhepr.13233$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30030872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yasui, Yutaka</creatorcontrib><creatorcontrib>Kurosaki, Masayuki</creatorcontrib><creatorcontrib>Komiyama, Yasuyuki</creatorcontrib><creatorcontrib>Takada, Hitomi</creatorcontrib><creatorcontrib>Tamaki, Nobuharu</creatorcontrib><creatorcontrib>Watakabe, Keiya</creatorcontrib><creatorcontrib>Okada, Mao</creatorcontrib><creatorcontrib>Wang, Wan</creatorcontrib><creatorcontrib>Shimizu, Takao</creatorcontrib><creatorcontrib>Kubota, Yohei</creatorcontrib><creatorcontrib>Higuchi, Mayu</creatorcontrib><creatorcontrib>Takaura, Kenta</creatorcontrib><creatorcontrib>Tsuchiya, Kaoru</creatorcontrib><creatorcontrib>Nakanishi, Hiroyuki</creatorcontrib><creatorcontrib>Takahashi, Yuka</creatorcontrib><creatorcontrib>Itakura, Jun</creatorcontrib><creatorcontrib>Enomoto, Nobuyuki</creatorcontrib><creatorcontrib>Izumi, Namiki</creatorcontrib><title>Wisteria floribunda agglutinin‐positive Mac‐2 binding protein predicts early occurrence of hepatocellular carcinoma after sustained virologic response by direct‐acting antivirals for hepatitis C virus</title><title>Hepatology research</title><addtitle>Hepatol Res</addtitle><description>Aim
The aim of this study is to clarify the value of serum Wisteria floribunda agglutinin‐positive Mac‐2 binding protein (WFA+‐M2BP) for predicting hepatocellular carcinoma (HCC) in chronic hepatitis C patients who achieved sustained virologic response (SVR) by therapy with interferon‐free, direct‐acting antivirals (DAAs).
Methods
This is a retrospective cohort study that included 567 patients who underwent antiviral therapy with an interferon‐free DAA regimen and achieved SVR. Serum WFA+‐M2BP was measured after SVR. Factors predictive of HCC occurrence and recurrence were analyzed in the patients after stratification by previous treatment history of HCC.
Results
Among 518 patients who had no history of HCC, 13 developed HCC. Post‐SVR WFA+‐M2BP ≥1.75 cut‐off index (C.O.I., P < 0.001) and α‐fetoprotein (AFP) level ≥6 ng/mL (P = 0.01) were significant predictors of HCC development. Multivariate analysis showed that post‐SVR WFA+‐M2BP ≥1.75 C.O.I. was an independent factor significantly associated with the development of HCC (hazard ratio [HR] 6.0; 95% confidence interval (CI), 1.8–19.4; P = 0.003). Among 49 patients who had a previous history of HCC, 22 had recurrence after SVR. Post‐SVR AFP ≥6 ng/mL was the only factor associated with recurrence‐free survival (HR 3.1; 95% CI, 1.3–7.5; P = 0.01).
Conclusions
Post‐SVR WFA+‐M2BP is a predictive factor for the development of HCC in patients with no previous HCC history and treated with DAAs. Post‐SVR AFP was predictive for HCC recurrence after DAA therapy.</description><subject>alpha‐fetoprotein</subject><subject>Antiviral agents</subject><subject>chronic hepatitis C</subject><subject>Hepatitis</subject><subject>Hepatitis C</subject><subject>Hepatocellular carcinoma</subject><subject>Interferon</subject><subject>Liver cancer</subject><subject>Multivariate analysis</subject><subject>Patients</subject><subject>Wisteria floribunda</subject><subject>Wisteria floribunda agglutinin‐positive Mac‐2 binding protein</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kU2KFTEUhQtR7B-duAAJOBGh2vxUVeoN5dHaQosiis6KVHLzvE29pMxPy5u5BFfWi3AlpqzWgQMzuQn5OOckp6oeMXrGynr-BeZwxgQX4k51zHrJayqaz3fLXvRd3YmmO6pOYryilEnKm_vVkaBU0AIeVzefMCYIqIidfMAxO6OI2u2mnNCh-_n9x-wjJrwG8kbpcuRkRGfQ7cgcfAJ0ZYJBnSIBFaYD8VrnEMBpIN6Skk0lr2Ga8qQC0SpodH5fPGyxJTHHpNCBIdcY_OR3qEmAOHsXgYwHYjCATsVW6bR4KleiYFBTJNaHVb2ki2S7COT4oLpnyyU8vJ2n1ceX5x-2F_Xl21evty8ua900UtRWCSEa3WpFR9Ex2Zi2fJUEJg20dtN1G6n7URvK-chaaUxneiu56BphxYYzcVo9XXXLJ3zNENOwx7i8UjnwOQ6cSlEK4b0s6JN_0CufgyvpBs7aXmyavl0En62UDj7GAHaYA-5VOAyMDkvLw9Ly8LvlAj--lczjHsxf9E-tBWAr8A0nOPxHarg4f_d-Ff0F27i6nw</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Yasui, Yutaka</creator><creator>Kurosaki, Masayuki</creator><creator>Komiyama, Yasuyuki</creator><creator>Takada, Hitomi</creator><creator>Tamaki, Nobuharu</creator><creator>Watakabe, Keiya</creator><creator>Okada, Mao</creator><creator>Wang, Wan</creator><creator>Shimizu, Takao</creator><creator>Kubota, Yohei</creator><creator>Higuchi, Mayu</creator><creator>Takaura, Kenta</creator><creator>Tsuchiya, Kaoru</creator><creator>Nakanishi, Hiroyuki</creator><creator>Takahashi, Yuka</creator><creator>Itakura, Jun</creator><creator>Enomoto, Nobuyuki</creator><creator>Izumi, Namiki</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6117-4990</orcidid></search><sort><creationdate>201812</creationdate><title>Wisteria floribunda agglutinin‐positive Mac‐2 binding protein predicts early occurrence of hepatocellular carcinoma after sustained virologic response by direct‐acting antivirals for hepatitis C virus</title><author>Yasui, Yutaka ; Kurosaki, Masayuki ; Komiyama, Yasuyuki ; Takada, Hitomi ; Tamaki, Nobuharu ; Watakabe, Keiya ; Okada, Mao ; Wang, Wan ; Shimizu, Takao ; Kubota, Yohei ; Higuchi, Mayu ; Takaura, Kenta ; Tsuchiya, Kaoru ; Nakanishi, Hiroyuki ; Takahashi, Yuka ; Itakura, Jun ; Enomoto, Nobuyuki ; Izumi, Namiki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4473-fa3334c5ca0b36174d53867e17de5f96697c8bcd022b157dd6d8f723643f39213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>alpha‐fetoprotein</topic><topic>Antiviral agents</topic><topic>chronic hepatitis C</topic><topic>Hepatitis</topic><topic>Hepatitis C</topic><topic>Hepatocellular carcinoma</topic><topic>Interferon</topic><topic>Liver cancer</topic><topic>Multivariate analysis</topic><topic>Patients</topic><topic>Wisteria floribunda</topic><topic>Wisteria floribunda agglutinin‐positive Mac‐2 binding protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yasui, Yutaka</creatorcontrib><creatorcontrib>Kurosaki, Masayuki</creatorcontrib><creatorcontrib>Komiyama, Yasuyuki</creatorcontrib><creatorcontrib>Takada, Hitomi</creatorcontrib><creatorcontrib>Tamaki, Nobuharu</creatorcontrib><creatorcontrib>Watakabe, Keiya</creatorcontrib><creatorcontrib>Okada, Mao</creatorcontrib><creatorcontrib>Wang, Wan</creatorcontrib><creatorcontrib>Shimizu, Takao</creatorcontrib><creatorcontrib>Kubota, Yohei</creatorcontrib><creatorcontrib>Higuchi, Mayu</creatorcontrib><creatorcontrib>Takaura, Kenta</creatorcontrib><creatorcontrib>Tsuchiya, Kaoru</creatorcontrib><creatorcontrib>Nakanishi, Hiroyuki</creatorcontrib><creatorcontrib>Takahashi, Yuka</creatorcontrib><creatorcontrib>Itakura, Jun</creatorcontrib><creatorcontrib>Enomoto, Nobuyuki</creatorcontrib><creatorcontrib>Izumi, Namiki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yasui, Yutaka</au><au>Kurosaki, Masayuki</au><au>Komiyama, Yasuyuki</au><au>Takada, Hitomi</au><au>Tamaki, Nobuharu</au><au>Watakabe, Keiya</au><au>Okada, Mao</au><au>Wang, Wan</au><au>Shimizu, Takao</au><au>Kubota, Yohei</au><au>Higuchi, Mayu</au><au>Takaura, Kenta</au><au>Tsuchiya, Kaoru</au><au>Nakanishi, Hiroyuki</au><au>Takahashi, Yuka</au><au>Itakura, Jun</au><au>Enomoto, Nobuyuki</au><au>Izumi, Namiki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wisteria floribunda agglutinin‐positive Mac‐2 binding protein predicts early occurrence of hepatocellular carcinoma after sustained virologic response by direct‐acting antivirals for hepatitis C virus</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2018-12</date><risdate>2018</risdate><volume>48</volume><issue>13</issue><spage>1131</spage><epage>1139</epage><pages>1131-1139</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>Aim
The aim of this study is to clarify the value of serum Wisteria floribunda agglutinin‐positive Mac‐2 binding protein (WFA+‐M2BP) for predicting hepatocellular carcinoma (HCC) in chronic hepatitis C patients who achieved sustained virologic response (SVR) by therapy with interferon‐free, direct‐acting antivirals (DAAs).
Methods
This is a retrospective cohort study that included 567 patients who underwent antiviral therapy with an interferon‐free DAA regimen and achieved SVR. Serum WFA+‐M2BP was measured after SVR. Factors predictive of HCC occurrence and recurrence were analyzed in the patients after stratification by previous treatment history of HCC.
Results
Among 518 patients who had no history of HCC, 13 developed HCC. Post‐SVR WFA+‐M2BP ≥1.75 cut‐off index (C.O.I., P < 0.001) and α‐fetoprotein (AFP) level ≥6 ng/mL (P = 0.01) were significant predictors of HCC development. Multivariate analysis showed that post‐SVR WFA+‐M2BP ≥1.75 C.O.I. was an independent factor significantly associated with the development of HCC (hazard ratio [HR] 6.0; 95% confidence interval (CI), 1.8–19.4; P = 0.003). Among 49 patients who had a previous history of HCC, 22 had recurrence after SVR. Post‐SVR AFP ≥6 ng/mL was the only factor associated with recurrence‐free survival (HR 3.1; 95% CI, 1.3–7.5; P = 0.01).
Conclusions
Post‐SVR WFA+‐M2BP is a predictive factor for the development of HCC in patients with no previous HCC history and treated with DAAs. Post‐SVR AFP was predictive for HCC recurrence after DAA therapy.</abstract><cop>Netherlands</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30030872</pmid><doi>10.1111/hepr.13233</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6117-4990</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1386-6346 |
| ispartof | Hepatology research, 2018-12, Vol.48 (13), p.1131-1139 |
| issn | 1386-6346 1872-034X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2073323287 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | alpha‐fetoprotein Antiviral agents chronic hepatitis C Hepatitis Hepatitis C Hepatocellular carcinoma Interferon Liver cancer Multivariate analysis Patients Wisteria floribunda Wisteria floribunda agglutinin‐positive Mac‐2 binding protein |
| title | Wisteria floribunda agglutinin‐positive Mac‐2 binding protein predicts early occurrence of hepatocellular carcinoma after sustained virologic response by direct‐acting antivirals for hepatitis C virus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T11%3A29%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Wisteria%20floribunda%20agglutinin%E2%80%90positive%20Mac%E2%80%902%20binding%20protein%20predicts%20early%20occurrence%20of%20hepatocellular%20carcinoma%20after%20sustained%20virologic%20response%20by%20direct%E2%80%90acting%20antivirals%20for%20hepatitis%20C%20virus&rft.jtitle=Hepatology%20research&rft.au=Yasui,%20Yutaka&rft.date=2018-12&rft.volume=48&rft.issue=13&rft.spage=1131&rft.epage=1139&rft.pages=1131-1139&rft.issn=1386-6346&rft.eissn=1872-034X&rft_id=info:doi/10.1111/hepr.13233&rft_dat=%3Cproquest_cross%3E2158394851%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2158394851&rft_id=info:pmid/30030872&rfr_iscdi=true |