Synthesis and evaluation of the cytotoxic activity of Furanaphthoquinones tethered to 1H-1,2,3-triazoles in Caco-2, Calu-3, MDA-MB231 cells

Naphthoquinones and 1,2,3-triazoles are structural pharmacophore that is known to impart several cancer cells. This work shows a synthetic methodology to obtain hybrid molecules involving naphthoquinone and triazol scaffold as multiple ligands. A simple and efficient synthetic route was used to prep...

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Veröffentlicht in:European journal of medicinal chemistry 2018-08, Vol.156, p.524-533
Hauptverfasser: Costa, Dora C.S., de Almeida, Gabriella Silva, Rabelo, Vitor Won-Held, Cabral, Lucio Mendes, Sathler, Plínio Cunha, Alvarez Abreu, Paula, Ferreira, Vitor Francisco, Cláudio Rodrigues Pereira da Silva, Luiz, da Silva, Fernando de C.
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Sprache:eng
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