Design, synthesis and screening of 1, 2, 4-triazinone derivatives as potential antitumor agents with apoptosis inducing activity on MCF-7 breast cancer cell line

Some triazinone derivatives are designed and synthesized as potential antitumor agents. Triazinone derivatives 4c, 5e and 7c show potent anticancer activity over MCF-7 breast cancer cells higher than podophyllotoxin (podo) by approximate 6-fold. DNA flow cytometry analysis for the compounds 3c, 4c,...

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Veröffentlicht in:	European journal of medicinal chemistry 2018-08, Vol.156, p.563-579
Hauptverfasser:	Zaki, Islam, Abdelhameid, Mohammed K., El-Deen, Ibrahim M., Abdel Wahab, Abdel Hady A., Ashmawy, Abeer M., Mohamed, Khaled O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Drug Design Female Humans MCF-7 Cells Topoisomerase II Inhibitors - chemical synthesis Topoisomerase II Inhibitors - chemistry Topoisomerase II Inhibitors - pharmacology Triazines - chemical synthesis Triazines - chemistry Triazines - pharmacology Tubulin - metabolism Tubulin Modulators - chemical synthesis Tubulin Modulators - chemistry Tubulin Modulators - pharmacology
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