Discovery of Presaccharothriolide X, a Retro-Michael Reaction Product of Saccharothriolide B, from the Rare Actinomycete Saccharothrix sp. A1506

The highly reactive precursor molecule, presaccharothriolide X, was successfully isolated from the rare actinomycete Saccharothrix sp. A1506. The comparable biological activity of presaccharothriolide X and its Michael addition product saccharothriolide B unveils a unique masking/activating property...

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Veröffentlicht in:	Organic letters 2018-08, Vol.20 (15), p.4406-4410
Hauptverfasser:	Lu, Shan, Nishimura, Shinichi, Takenaka, Kei, Ito, Masashi, Kato, Taira, Kakeya, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinobacteria - chemistry Aminophenols - chemistry Anti-Infective Agents - chemistry Cell Line, Tumor Cell Proliferation - drug effects Cytotoxins - chemistry Cytotoxins - pharmacology Humans Macrolides - chemistry Macrolides - pharmacology Molecular Structure Oxidation-Reduction Schizosaccharomyces - cytology Schizosaccharomyces - drug effects
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