The Saccharomyces cerevisiae Sae2 Protein Promotes Resection and Bridging of Double Strand Break Ends

When eukaryotic chromosomes undergo double strand breaks (DSBs), several evolutionarily conserved proteins, among which the MRX complex, are recruited to the break site, leading to checkpoint activation and DNA repair. The function of the Saccharomyces cerevisiae Sae2 protein, which is known to work...

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Veröffentlicht in:	The Journal of biological chemistry 2005-11, Vol.280 (46), p.38631-38638
Hauptverfasser:	Clerici, Michela, Mantiero, Davide, Lucchini, Giovanna, Longhese, Maria Pia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Blotting, Western Chromosomes - ultrastructure DNA Damage DNA Repair Endonucleases Evolution, Molecular Gene Deletion Meiosis Mitosis Models, Genetic Nucleic Acid Hybridization Plasmids - metabolism Polymerase Chain Reaction Protein Binding Saccharomyces cerevisiae Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Saccharomyces cerevisiae Proteins - physiology Time Factors
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