The Novel Poly(ADP-Ribose) Polymerase Inhibitor, AG14361, Sensitizes Cells to Topoisomerase I Poisons by Increasing the Persistence of DNA Strand Breaks

Poly(ADP-ribose) polymerase (PARP) inhibitors enhance DNA topoisomerase I (topo I) poison-induced cytotoxicity and antitumor activity in vitro and in vivo , but the mechanism has not been defined. We investigated the role of PARP-1 in the response to topo I poisons using PARP-1 −/− and PARP-1 +/+ mo...

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Veröffentlicht in:	Clinical cancer research 2005-12, Vol.11 (23), p.8449-8457
Hauptverfasser:	Smith, Lisa M, Willmore, Elaine, Austin, Caroline A, Curtin, Nicola J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticancer sensitization Antineoplastic Agents, Phytogenic - pharmacology Azulenes Benzodiazepines - pharmacology camptothecin Camptothecin - toxicity CHO Cells - drug effects Cricetinae DNA Damage - drug effects DNA repair DNA Repair - drug effects DNA topoisomerase I DNA Topoisomerases, Type I - metabolism Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Female Fibroblasts - drug effects Fibroblasts - enzymology Humans K562 Cells - drug effects Mice Mice, Knockout poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors Topoisomerase I Inhibitors Topotecan - toxicity Tumor Stem Cell Assay
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