Biotransformation of polybrominated diphenyl ethers and polychlorinated biphenyls in beluga whale ( Delphinapterus leucas) and rat mammalian model using an in vitro hepatic microsomal assay

Although polychlorinated biphenyls (PCBs) and polybrominated diphenyl ether (PBDE) flame retardants are important organic contaminants in the tissues of marine mammals, including those species from the Arctic, there is exceedingly little direct evidence on congener-specific biotransformation. We det...

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Veröffentlicht in:	Aquatic toxicology 2006-04, Vol.77 (1), p.87-97
Hauptverfasser:	McKinney, Melissa A., De Guise, Sylvain, Martineau, Daniel, Béland, Pierre, Arukwe, Augustine, Letcher, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models animal physiology Animal, plant and microbial ecology Animals Applied ecology Beluga whale ( Delphinapterus leucas) Beluga Whale - metabolism bioassays Biological and medical sciences Biotransformation Bromides - analysis Cetacea Cytochrome P-450 Enzyme System - metabolism Delphinapterus leucas Ecotoxicology, biological effects of pollution Environmental Pollutants - analysis Environmental Pollutants - pharmacokinetics enzyme activity Fundamental and applied biological sciences. Psychology General aspects Halogenated Diphenyl Ethers Hepatic microsomes In vitro biotransformation in vitro culture liver Male Mammalia metabolism microsomes Microsomes, Liver - enzymology Microsomes, Liver - metabolism Models, Animal pharmacokinetics Phenol - chemistry Phenyl Ethers - analysis Phenyl Ethers - pharmacokinetics Polybrominated Biphenyls - analysis Polybrominated Biphenyls - pharmacokinetics Polybrominated diphenyl ethers Polychlorinated biphenyls Polychlorinated Biphenyls - analysis Polychlorinated Biphenyls - pharmacokinetics protein content Proteins - analysis Rats Rats, Wistar Time Factors Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution water pollution whales
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