Curcumin for malaria therapy
Malaria remains a major global health concern. New, inexpensive, and effective antimalarial agents are urgently needed. Here we show that curcumin, a polyphenolic organic molecule derived from turmeric, inhibits chloroquine-resistant Plasmodium falciparum growth in culture in a dose dependent manner...
Gespeichert in:
| Veröffentlicht in: | Biochemical and biophysical research communications 2005-01, Vol.326 (2), p.472-474 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 474 |
|---|---|
| container_issue | 2 |
| container_start_page | 472 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 326 |
| creator | Reddy, Raju C. Vatsala, Palakkodu G. Keshamouni, Venkateshwar G. Padmanaban, Govindarajan Rangarajan, Pundi N. |
| description | Malaria remains a major global health concern. New, inexpensive, and effective antimalarial agents are urgently needed. Here we show that curcumin, a polyphenolic organic molecule derived from turmeric, inhibits chloroquine-resistant
Plasmodium falciparum growth in culture in a dose dependent manner with an IC
50 of ∼5
μM. Additionally, oral administration of curcumin to mice infected with malaria parasite (
Plasmodium berghei) reduces blood parasitemia by 80–90% and enhances their survival significantly. Thus, curcumin may represent a novel treatment for malarial infection. |
| doi_str_mv | 10.1016/j.bbrc.2004.11.051 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20728538</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X04026130</els_id><sourcerecordid>20728538</sourcerecordid><originalsourceid>FETCH-LOGICAL-c383t-b8f6f4c5c1230a4787f539f62dad1320b28b9a8c7642d6ca35b4d07b31e2e06d3</originalsourceid><addsrcrecordid>eNp9kEtLw0AUhQdRbK3-ARHpyl3ivTOTyQTcSPEFBTcK7oZ5BackTZ1JhP77prTgztXdnPMd7kfINUKOgOJ-lRsTbU4BeI6YQ4EnZIpQQUYR-CmZAoDIaIVfE3KR0goAkYvqnEywKCQVgFNysxiiHdqwntddnLe60THoef_to95sL8lZrZvkr453Rj6fnz4Wr9ny_eVt8bjMLJOsz4ysRc1tYZEy0LyUZV2wqhbUaYeMgqHSVFraUnDqhNWsMNxBaRh66kE4NiN3B-4mdj-DT71qQ7K-afTad0NSFEoqi3FrRughaGOXUvS12sTQ6rhVCGrvRK3U3onaO1GIanQylm6P9MG03v1VjhLGwMMh4Mcff4OPKtng19a7EL3tlevCf_wd-vNwjA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20728538</pqid></control><display><type>article</type><title>Curcumin for malaria therapy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Reddy, Raju C. ; Vatsala, Palakkodu G. ; Keshamouni, Venkateshwar G. ; Padmanaban, Govindarajan ; Rangarajan, Pundi N.</creator><creatorcontrib>Reddy, Raju C. ; Vatsala, Palakkodu G. ; Keshamouni, Venkateshwar G. ; Padmanaban, Govindarajan ; Rangarajan, Pundi N.</creatorcontrib><description>Malaria remains a major global health concern. New, inexpensive, and effective antimalarial agents are urgently needed. Here we show that curcumin, a polyphenolic organic molecule derived from turmeric, inhibits chloroquine-resistant
Plasmodium falciparum growth in culture in a dose dependent manner with an IC
50 of ∼5
μM. Additionally, oral administration of curcumin to mice infected with malaria parasite (
Plasmodium berghei) reduces blood parasitemia by 80–90% and enhances their survival significantly. Thus, curcumin may represent a novel treatment for malarial infection.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2004.11.051</identifier><identifier>PMID: 15582601</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Antimalarials - administration & dosage ; Antimalarials - pharmacology ; Antimalarials - therapeutic use ; Artemisinin ; Curcuma longa ; Curcumin ; Curcumin - administration & dosage ; Curcumin - pharmacology ; Curcumin - therapeutic use ; Inhibitory Concentration 50 ; Malaria ; Malaria - blood ; Malaria - drug therapy ; Malaria - parasitology ; Male ; Mice ; Parasitemia - blood ; Parasitemia - drug therapy ; Parasitemia - parasitology ; Plasmodium ; Plasmodium berghei ; Plasmodium berghei - drug effects ; Plasmodium falciparum ; Plasmodium falciparum - drug effects ; Plasmodium falciparum - growth & development ; Survival Rate</subject><ispartof>Biochemical and biophysical research communications, 2005-01, Vol.326 (2), p.472-474</ispartof><rights>2004 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-b8f6f4c5c1230a4787f539f62dad1320b28b9a8c7642d6ca35b4d07b31e2e06d3</citedby><cites>FETCH-LOGICAL-c383t-b8f6f4c5c1230a4787f539f62dad1320b28b9a8c7642d6ca35b4d07b31e2e06d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X04026130$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15582601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reddy, Raju C.</creatorcontrib><creatorcontrib>Vatsala, Palakkodu G.</creatorcontrib><creatorcontrib>Keshamouni, Venkateshwar G.</creatorcontrib><creatorcontrib>Padmanaban, Govindarajan</creatorcontrib><creatorcontrib>Rangarajan, Pundi N.</creatorcontrib><title>Curcumin for malaria therapy</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Malaria remains a major global health concern. New, inexpensive, and effective antimalarial agents are urgently needed. Here we show that curcumin, a polyphenolic organic molecule derived from turmeric, inhibits chloroquine-resistant
Plasmodium falciparum growth in culture in a dose dependent manner with an IC
50 of ∼5
μM. Additionally, oral administration of curcumin to mice infected with malaria parasite (
Plasmodium berghei) reduces blood parasitemia by 80–90% and enhances their survival significantly. Thus, curcumin may represent a novel treatment for malarial infection.</description><subject>Animals</subject><subject>Antimalarials - administration & dosage</subject><subject>Antimalarials - pharmacology</subject><subject>Antimalarials - therapeutic use</subject><subject>Artemisinin</subject><subject>Curcuma longa</subject><subject>Curcumin</subject><subject>Curcumin - administration & dosage</subject><subject>Curcumin - pharmacology</subject><subject>Curcumin - therapeutic use</subject><subject>Inhibitory Concentration 50</subject><subject>Malaria</subject><subject>Malaria - blood</subject><subject>Malaria - drug therapy</subject><subject>Malaria - parasitology</subject><subject>Male</subject><subject>Mice</subject><subject>Parasitemia - blood</subject><subject>Parasitemia - drug therapy</subject><subject>Parasitemia - parasitology</subject><subject>Plasmodium</subject><subject>Plasmodium berghei</subject><subject>Plasmodium berghei - drug effects</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Plasmodium falciparum - growth & development</subject><subject>Survival Rate</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AUhQdRbK3-ARHpyl3ivTOTyQTcSPEFBTcK7oZ5BackTZ1JhP77prTgztXdnPMd7kfINUKOgOJ-lRsTbU4BeI6YQ4EnZIpQQUYR-CmZAoDIaIVfE3KR0goAkYvqnEywKCQVgFNysxiiHdqwntddnLe60THoef_to95sL8lZrZvkr453Rj6fnz4Wr9ny_eVt8bjMLJOsz4ysRc1tYZEy0LyUZV2wqhbUaYeMgqHSVFraUnDqhNWsMNxBaRh66kE4NiN3B-4mdj-DT71qQ7K-afTad0NSFEoqi3FrRughaGOXUvS12sTQ6rhVCGrvRK3U3onaO1GIanQylm6P9MG03v1VjhLGwMMh4Mcff4OPKtng19a7EL3tlevCf_wd-vNwjA</recordid><startdate>20050114</startdate><enddate>20050114</enddate><creator>Reddy, Raju C.</creator><creator>Vatsala, Palakkodu G.</creator><creator>Keshamouni, Venkateshwar G.</creator><creator>Padmanaban, Govindarajan</creator><creator>Rangarajan, Pundi N.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope></search><sort><creationdate>20050114</creationdate><title>Curcumin for malaria therapy</title><author>Reddy, Raju C. ; Vatsala, Palakkodu G. ; Keshamouni, Venkateshwar G. ; Padmanaban, Govindarajan ; Rangarajan, Pundi N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-b8f6f4c5c1230a4787f539f62dad1320b28b9a8c7642d6ca35b4d07b31e2e06d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antimalarials - administration & dosage</topic><topic>Antimalarials - pharmacology</topic><topic>Antimalarials - therapeutic use</topic><topic>Artemisinin</topic><topic>Curcuma longa</topic><topic>Curcumin</topic><topic>Curcumin - administration & dosage</topic><topic>Curcumin - pharmacology</topic><topic>Curcumin - therapeutic use</topic><topic>Inhibitory Concentration 50</topic><topic>Malaria</topic><topic>Malaria - blood</topic><topic>Malaria - drug therapy</topic><topic>Malaria - parasitology</topic><topic>Male</topic><topic>Mice</topic><topic>Parasitemia - blood</topic><topic>Parasitemia - drug therapy</topic><topic>Parasitemia - parasitology</topic><topic>Plasmodium</topic><topic>Plasmodium berghei</topic><topic>Plasmodium berghei - drug effects</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - drug effects</topic><topic>Plasmodium falciparum - growth & development</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reddy, Raju C.</creatorcontrib><creatorcontrib>Vatsala, Palakkodu G.</creatorcontrib><creatorcontrib>Keshamouni, Venkateshwar G.</creatorcontrib><creatorcontrib>Padmanaban, Govindarajan</creatorcontrib><creatorcontrib>Rangarajan, Pundi N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reddy, Raju C.</au><au>Vatsala, Palakkodu G.</au><au>Keshamouni, Venkateshwar G.</au><au>Padmanaban, Govindarajan</au><au>Rangarajan, Pundi N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curcumin for malaria therapy</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2005-01-14</date><risdate>2005</risdate><volume>326</volume><issue>2</issue><spage>472</spage><epage>474</epage><pages>472-474</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Malaria remains a major global health concern. New, inexpensive, and effective antimalarial agents are urgently needed. Here we show that curcumin, a polyphenolic organic molecule derived from turmeric, inhibits chloroquine-resistant
Plasmodium falciparum growth in culture in a dose dependent manner with an IC
50 of ∼5
μM. Additionally, oral administration of curcumin to mice infected with malaria parasite (
Plasmodium berghei) reduces blood parasitemia by 80–90% and enhances their survival significantly. Thus, curcumin may represent a novel treatment for malarial infection.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15582601</pmid><doi>10.1016/j.bbrc.2004.11.051</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 2005-01, Vol.326 (2), p.472-474 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20728538 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antimalarials - administration & dosage Antimalarials - pharmacology Antimalarials - therapeutic use Artemisinin Curcuma longa Curcumin Curcumin - administration & dosage Curcumin - pharmacology Curcumin - therapeutic use Inhibitory Concentration 50 Malaria Malaria - blood Malaria - drug therapy Malaria - parasitology Male Mice Parasitemia - blood Parasitemia - drug therapy Parasitemia - parasitology Plasmodium Plasmodium berghei Plasmodium berghei - drug effects Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - growth & development Survival Rate |
| title | Curcumin for malaria therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T21%3A51%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Curcumin%20for%20malaria%20therapy&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Reddy,%20Raju%20C.&rft.date=2005-01-14&rft.volume=326&rft.issue=2&rft.spage=472&rft.epage=474&rft.pages=472-474&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1016/j.bbrc.2004.11.051&rft_dat=%3Cproquest_cross%3E20728538%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20728538&rft_id=info:pmid/15582601&rft_els_id=S0006291X04026130&rfr_iscdi=true |