Vitamin D Receptor Gene Polymorphisms and Epithelial Ovarian Cancer Risk
Epidemiologic and laboratory studies support a role for the vitamin D endocrine system in ovarian carcinogenesis. The association of ovarian cancer risk with polymorphisms in the vitamin D receptor ( VDR ) gene, including rs10735810 ( Fok I), rs11568820 ( Cdx -2), rs1544410 ( Bsm I), rs7975232 ( Apa...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2007-12, Vol.16 (12), p.2566-2571 |
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| creator | LURIE, Galina WILKENS, Lynne R THOMPSON, Pamela J MCDUFFIE, Katharine E CARNEY, Michael E TERADA, Keith Y GOODMAN, Marc T |
| description | Epidemiologic and laboratory studies support a role for the vitamin D endocrine system in ovarian carcinogenesis. The association
of ovarian cancer risk with polymorphisms in the vitamin D receptor ( VDR ) gene, including rs10735810 ( Fok I), rs11568820 ( Cdx -2), rs1544410 ( Bsm I), rs7975232 ( Apa I), rs731236 ( Taq I), and Bsm I- Apa I- Taq I combined genotypes, was examined among 313 women with epithelial ovarian carcinoma and 574 controls. Odds ratios (OR) and
95% confidence intervals (95% CI) were estimated using unconditional logistic regression. The associations of VDR polymorphisms with risk were generally inconsistent across ethnic groups. Among Caucasian women (72 cases, 148 controls),
heterozygous and homozygous Apa I A allele carriers were at increased ovarian carcinoma risk compared with homozygous carriers of the Apa I a allele (OR 2.8, 95% CI 1.2-7.0 and OR 3.4, 95% CI 1.3-9.1; P trend = 0.02). Caucasian heterozygous carriers of Fok I f allele were also at increased risk of ovarian carcinoma compared with homozygous carriers of the common allele (OR 2.5, 95%
CI 1.3-4.8; P trend = 0.04). Among Japanese women (94 cases, 173 controls), ovarian cancer risk was significantly decreased (OR 0.5, 95% CI 0.3-0.9)
among Cdx-2 A allele heterozygotes compared with homozygote G allele carriers ( P trend = 0.03). Compared with the bbaaTT Bsm I- Apa I- Taq I genotype, bbaATT and BBAAtt genotypes were associated with increased ovarian cancer risk in Caucasian women (OR 4.2, 95% CI 1.3-13.1 and OR 5.2, 95%
CI 1.6-17.5), but not in Japanese women (OR 1.1, 95% CI 0.6-1.9 and OR 2.3, 95% CI:0.4-12.3). This investigation provides
some evidence that polymorphisms in the VDR gene might influence ovarian cancer susceptibility. (Cancer Epidemiol Biomarkers Prev 2007;16(12):2566–71) |
| doi_str_mv | 10.1158/1055-9965.EPI-07-0753 |
| format | Article |
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of ovarian cancer risk with polymorphisms in the vitamin D receptor ( VDR ) gene, including rs10735810 ( Fok I), rs11568820 ( Cdx -2), rs1544410 ( Bsm I), rs7975232 ( Apa I), rs731236 ( Taq I), and Bsm I- Apa I- Taq I combined genotypes, was examined among 313 women with epithelial ovarian carcinoma and 574 controls. Odds ratios (OR) and
95% confidence intervals (95% CI) were estimated using unconditional logistic regression. The associations of VDR polymorphisms with risk were generally inconsistent across ethnic groups. Among Caucasian women (72 cases, 148 controls),
heterozygous and homozygous Apa I A allele carriers were at increased ovarian carcinoma risk compared with homozygous carriers of the Apa I a allele (OR 2.8, 95% CI 1.2-7.0 and OR 3.4, 95% CI 1.3-9.1; P trend = 0.02). Caucasian heterozygous carriers of Fok I f allele were also at increased risk of ovarian carcinoma compared with homozygous carriers of the common allele (OR 2.5, 95%
CI 1.3-4.8; P trend = 0.04). Among Japanese women (94 cases, 173 controls), ovarian cancer risk was significantly decreased (OR 0.5, 95% CI 0.3-0.9)
among Cdx-2 A allele heterozygotes compared with homozygote G allele carriers ( P trend = 0.03). Compared with the bbaaTT Bsm I- Apa I- Taq I genotype, bbaATT and BBAAtt genotypes were associated with increased ovarian cancer risk in Caucasian women (OR 4.2, 95% CI 1.3-13.1 and OR 5.2, 95%
CI 1.6-17.5), but not in Japanese women (OR 1.1, 95% CI 0.6-1.9 and OR 2.3, 95% CI:0.4-12.3). This investigation provides
some evidence that polymorphisms in the VDR gene might influence ovarian cancer susceptibility. (Cancer Epidemiol Biomarkers Prev 2007;16(12):2566–71)</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-07-0753</identifier><identifier>PMID: 18086759</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Case-Control Studies ; case-control study ; Continental Population Groups ; epithelial ovarian cancer ; Female ; Female genital diseases ; genetic epidemiology ; Genetic Predisposition to Disease - ethnology ; Genotype ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Middle Aged ; Neoplasms, Glandular and Epithelial - ethnology ; Neoplasms, Glandular and Epithelial - genetics ; Ovarian Neoplasms - ethnology ; Ovarian Neoplasms - genetics ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Receptors, Calcitriol - genetics ; Risk Factors ; single-nucleotide polymorphisms ; Tumors ; VDR ; vitamin D receptor gene</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2007-12, Vol.16 (12), p.2566-2571</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-a2d0a8d4dd7bec0114539bc6a2331b1fef17ff63f31b4ee547ee751c14b533ce3</citedby><cites>FETCH-LOGICAL-c402t-a2d0a8d4dd7bec0114539bc6a2331b1fef17ff63f31b4ee547ee751c14b533ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20009866$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18086759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LURIE, Galina</creatorcontrib><creatorcontrib>WILKENS, Lynne R</creatorcontrib><creatorcontrib>THOMPSON, Pamela J</creatorcontrib><creatorcontrib>MCDUFFIE, Katharine E</creatorcontrib><creatorcontrib>CARNEY, Michael E</creatorcontrib><creatorcontrib>TERADA, Keith Y</creatorcontrib><creatorcontrib>GOODMAN, Marc T</creatorcontrib><title>Vitamin D Receptor Gene Polymorphisms and Epithelial Ovarian Cancer Risk</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Epidemiologic and laboratory studies support a role for the vitamin D endocrine system in ovarian carcinogenesis. The association
of ovarian cancer risk with polymorphisms in the vitamin D receptor ( VDR ) gene, including rs10735810 ( Fok I), rs11568820 ( Cdx -2), rs1544410 ( Bsm I), rs7975232 ( Apa I), rs731236 ( Taq I), and Bsm I- Apa I- Taq I combined genotypes, was examined among 313 women with epithelial ovarian carcinoma and 574 controls. Odds ratios (OR) and
95% confidence intervals (95% CI) were estimated using unconditional logistic regression. The associations of VDR polymorphisms with risk were generally inconsistent across ethnic groups. Among Caucasian women (72 cases, 148 controls),
heterozygous and homozygous Apa I A allele carriers were at increased ovarian carcinoma risk compared with homozygous carriers of the Apa I a allele (OR 2.8, 95% CI 1.2-7.0 and OR 3.4, 95% CI 1.3-9.1; P trend = 0.02). Caucasian heterozygous carriers of Fok I f allele were also at increased risk of ovarian carcinoma compared with homozygous carriers of the common allele (OR 2.5, 95%
CI 1.3-4.8; P trend = 0.04). Among Japanese women (94 cases, 173 controls), ovarian cancer risk was significantly decreased (OR 0.5, 95% CI 0.3-0.9)
among Cdx-2 A allele heterozygotes compared with homozygote G allele carriers ( P trend = 0.03). Compared with the bbaaTT Bsm I- Apa I- Taq I genotype, bbaATT and BBAAtt genotypes were associated with increased ovarian cancer risk in Caucasian women (OR 4.2, 95% CI 1.3-13.1 and OR 5.2, 95%
CI 1.6-17.5), but not in Japanese women (OR 1.1, 95% CI 0.6-1.9 and OR 2.3, 95% CI:0.4-12.3). This investigation provides
some evidence that polymorphisms in the VDR gene might influence ovarian cancer susceptibility. (Cancer Epidemiol Biomarkers Prev 2007;16(12):2566–71)</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>case-control study</subject><subject>Continental Population Groups</subject><subject>epithelial ovarian cancer</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>genetic epidemiology</subject><subject>Genetic Predisposition to Disease - ethnology</subject><subject>Genotype</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms, Glandular and Epithelial - ethnology</subject><subject>Neoplasms, Glandular and Epithelial - genetics</subject><subject>Ovarian Neoplasms - ethnology</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Risk Factors</subject><subject>single-nucleotide polymorphisms</subject><subject>Tumors</subject><subject>VDR</subject><subject>vitamin D receptor gene</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0MtKxDAUgOEgivdHULJRcFFNmp6mXco4XkCYQdRtSNNTG-3NpKP49macUSGQBL6TwE_IEWfnnEN2wRlAlOcpnE_ndxGTYYHYILscRBZJCbAZzr9mh-x5_8oYkznANtnhGctSCfkuuX22o25tR6_oAxocxt7RG-yQzvvmq-3dUFvfeqq7kk4HO9bYWN3Q2Yd2Vnd0ojuDjj5Y_3ZAtirdeDxc7_vk6Xr6OLmN7mc3d5PL-8gkLB4jHZdMZ2VSlrJAwzhPQOSFSXUsBC94hRWXVZWKKtwSREgkogRueFKAEAbFPjldvTu4_n2BflSt9QabRnfYL7yKmYwly5MAYQWN6713WKnB2Va7L8WZWiZUyzxqmUeFhIpJtUwY5o7XHyyKFsv_qXWzAE7WQHujm8qFCNb_uThkzrM0De5s5Wr7Un9ah8r85HLoUTtTK54qHqsYgv0GjZ-H2A</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>LURIE, Galina</creator><creator>WILKENS, Lynne R</creator><creator>THOMPSON, Pamela J</creator><creator>MCDUFFIE, Katharine E</creator><creator>CARNEY, Michael E</creator><creator>TERADA, Keith Y</creator><creator>GOODMAN, Marc T</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20071201</creationdate><title>Vitamin D Receptor Gene Polymorphisms and Epithelial Ovarian Cancer Risk</title><author>LURIE, Galina ; WILKENS, Lynne R ; THOMPSON, Pamela J ; MCDUFFIE, Katharine E ; CARNEY, Michael E ; TERADA, Keith Y ; GOODMAN, Marc T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-a2d0a8d4dd7bec0114539bc6a2331b1fef17ff63f31b4ee547ee751c14b533ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>case-control study</topic><topic>Continental Population Groups</topic><topic>epithelial ovarian cancer</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>genetic epidemiology</topic><topic>Genetic Predisposition to Disease - ethnology</topic><topic>Genotype</topic><topic>Gynecology. 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The association
of ovarian cancer risk with polymorphisms in the vitamin D receptor ( VDR ) gene, including rs10735810 ( Fok I), rs11568820 ( Cdx -2), rs1544410 ( Bsm I), rs7975232 ( Apa I), rs731236 ( Taq I), and Bsm I- Apa I- Taq I combined genotypes, was examined among 313 women with epithelial ovarian carcinoma and 574 controls. Odds ratios (OR) and
95% confidence intervals (95% CI) were estimated using unconditional logistic regression. The associations of VDR polymorphisms with risk were generally inconsistent across ethnic groups. Among Caucasian women (72 cases, 148 controls),
heterozygous and homozygous Apa I A allele carriers were at increased ovarian carcinoma risk compared with homozygous carriers of the Apa I a allele (OR 2.8, 95% CI 1.2-7.0 and OR 3.4, 95% CI 1.3-9.1; P trend = 0.02). Caucasian heterozygous carriers of Fok I f allele were also at increased risk of ovarian carcinoma compared with homozygous carriers of the common allele (OR 2.5, 95%
CI 1.3-4.8; P trend = 0.04). Among Japanese women (94 cases, 173 controls), ovarian cancer risk was significantly decreased (OR 0.5, 95% CI 0.3-0.9)
among Cdx-2 A allele heterozygotes compared with homozygote G allele carriers ( P trend = 0.03). Compared with the bbaaTT Bsm I- Apa I- Taq I genotype, bbaATT and BBAAtt genotypes were associated with increased ovarian cancer risk in Caucasian women (OR 4.2, 95% CI 1.3-13.1 and OR 5.2, 95%
CI 1.6-17.5), but not in Japanese women (OR 1.1, 95% CI 0.6-1.9 and OR 2.3, 95% CI:0.4-12.3). This investigation provides
some evidence that polymorphisms in the VDR gene might influence ovarian cancer susceptibility. (Cancer Epidemiol Biomarkers Prev 2007;16(12):2566–71)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>18086759</pmid><doi>10.1158/1055-9965.EPI-07-0753</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Case-Control Studies case-control study Continental Population Groups epithelial ovarian cancer Female Female genital diseases genetic epidemiology Genetic Predisposition to Disease - ethnology Genotype Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Neoplasms, Glandular and Epithelial - ethnology Neoplasms, Glandular and Epithelial - genetics Ovarian Neoplasms - ethnology Ovarian Neoplasms - genetics Polymerase Chain Reaction Polymorphism, Genetic Receptors, Calcitriol - genetics Risk Factors single-nucleotide polymorphisms Tumors VDR vitamin D receptor gene |
| title | Vitamin D Receptor Gene Polymorphisms and Epithelial Ovarian Cancer Risk |
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