Selenium protects the hypoxia induced apoptosis in neuroblastoma cells through upregulation of Bcl-2

Abstract Selenium (Se) is an essential micronutrient as well as a toxic trace element in animal and human nutrition. The effects of Se in the immune system and some diseases are well documented. The objective of the present study was to examine the role of Se in reducing the hypoxia induced apoptosi...

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Veröffentlicht in:	Brain research 2008-05, Vol.1209, p.29-39
Hauptverfasser:	Sarada, S.K.S, Himadri, P, Ruma, D, Sharma, S.K, Pauline, T, Mrinalini
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Cell Line, Tumor Cell physiology Cytotoxicity DNA Fragmentation - drug effects Free Radicals - metabolism Fundamental and applied biological sciences. Psychology Glutathione - metabolism Hypoxia Hypoxia, Brain - drug therapy Hypoxia, Brain - metabolism Hypoxia, Brain - physiopathology Hypoxia-Inducible Factor 1, alpha Subunit - drug effects Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice Molecular and cellular biology Nerve Degeneration - drug therapy Nerve Degeneration - metabolism Nerve Degeneration - physiopathology Neuroblastoma Neurology Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Proto-Oncogene Proteins c-bcl-2 - drug effects Proto-Oncogene Proteins c-bcl-2 - metabolism Selenium Selenium - pharmacology Superoxide Dismutase - drug effects Superoxide Dismutase - metabolism Up-Regulation - drug effects Up-Regulation - physiology
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