Toxic effects of methoxychlor administered subcutaneously on the hypothalamic-pituitary-testicular axis in adult rats
This study was undertaken to evaluate the effects of methoxychlor MTX at the hypothalamic-pituitary-testicular axis in adult male rats. This global objective comprises three major aims: (1) to analyze the possible differential MTX effects in norepinephrine and serotonin concentration an in serotonin...
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| Veröffentlicht in: | Food and chemical toxicology 2008-05, Vol.46 (5), p.1570-1575 |
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| creator | Lafuente, A. Cabaleiro, T. Caride, A. Esquifino, A.I. |
| description | This study was undertaken to evaluate the effects of methoxychlor MTX at the hypothalamic-pituitary-testicular axis in adult male rats. This global objective comprises three major aims: (1) to analyze the possible differential MTX effects in norepinephrine and serotonin concentration an in serotoninergic metabolism in anterior, mediobasal and posterior hypothalamus and median eminence; (2) to evaluate effects induced by MTX exposure on gonadotropins and testosterone; 93 to elucidate whether the regulatory interactions in the hypothalamic-pituitary-testicular axis are modified by this pesticide. Animals were administered subcutaneously 25mg/kg/day of MTX for 1 month. MTX increased norepinephrine and serotonin content in anterior hypothalamus (P⩽0.05), but decreased serotonin concentration in posterior hypothalamus (P⩽0.05). MTX diminished serotonin turnover in anterior hypothalamus (P⩽0.01) and decreased plasma LH (P⩽0.001) and testosterone (P⩽0.05) levels but those of FSH remained unmodified. We can conclude that MTX exposure: (1) could exert differential effects in norepinephrine and serotonin concentration an in serotoninergic metabolism in anterior, mediobasal and posterior hypothalamus and median eminence, being the anterior hypothalamus the most sensitive region to the pesticide; (2) could inhibit LH and testosterone secretion without changing FSH; (3) four potential pathways might be involved in MTX effects on testosterone secretion (changing LH secretion; modifying serotonin and norepinephrine at the hypothalamic level; alterating the direct neural pathway between brain and testes; and/or by a direct effect in testes). |
| doi_str_mv | 10.1016/j.fct.2007.12.017 |
| format | Article |
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This global objective comprises three major aims: (1) to analyze the possible differential MTX effects in norepinephrine and serotonin concentration an in serotoninergic metabolism in anterior, mediobasal and posterior hypothalamus and median eminence; (2) to evaluate effects induced by MTX exposure on gonadotropins and testosterone; 93 to elucidate whether the regulatory interactions in the hypothalamic-pituitary-testicular axis are modified by this pesticide. Animals were administered subcutaneously 25mg/kg/day of MTX for 1 month. MTX increased norepinephrine and serotonin content in anterior hypothalamus (P⩽0.05), but decreased serotonin concentration in posterior hypothalamus (P⩽0.05). MTX diminished serotonin turnover in anterior hypothalamus (P⩽0.01) and decreased plasma LH (P⩽0.001) and testosterone (P⩽0.05) levels but those of FSH remained unmodified. We can conclude that MTX exposure: (1) could exert differential effects in norepinephrine and serotonin concentration an in serotoninergic metabolism in anterior, mediobasal and posterior hypothalamus and median eminence, being the anterior hypothalamus the most sensitive region to the pesticide; (2) could inhibit LH and testosterone secretion without changing FSH; (3) four potential pathways might be involved in MTX effects on testosterone secretion (changing LH secretion; modifying serotonin and norepinephrine at the hypothalamic level; alterating the direct neural pathway between brain and testes; and/or by a direct effect in testes).</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2007.12.017</identifier><identifier>PMID: 18226848</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>5-Hydroxyindole acetic acid ; adult animals ; Adult rats ; animal models ; Animals ; biochemical pathways ; Biological and medical sciences ; blood chemistry ; dietary exposure ; endocrine-disrupting chemicals ; Follicle stimulating hormone ; Follicle Stimulating Hormone - blood ; gonadotropins ; Gonadotropins - metabolism ; hormone secretion ; Hypothalamo-Hypophyseal System - drug effects ; Hypothalamo-Hypophyseal System - metabolism ; hypothalamus ; Hypothalamus - metabolism ; Injections, Subcutaneous ; insecticide residues ; Insecticides - administration & dosage ; Insecticides - toxicity ; Luteinizing hormone ; Luteinizing Hormone - blood ; Male ; males ; Median Eminence - drug effects ; Median Eminence - metabolism ; Medical sciences ; metabolism ; Methoxychlor ; Methoxychlor - administration & dosage ; Methoxychlor - toxicity ; Norepinephrine ; Norepinephrine - metabolism ; Pesticides, fertilizers and other agrochemicals toxicology ; pituitary gland ; Rats ; Rats, Sprague-Dawley ; Serotonin ; Serotonin - metabolism ; subcutaneous injection ; testes ; Testis - drug effects ; Testis - metabolism ; Testosterone ; Testosterone - metabolism ; toxicity ; Toxicology</subject><ispartof>Food and chemical toxicology, 2008-05, Vol.46 (5), p.1570-1575</ispartof><rights>2007 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-f221a3005848a7ad17606d7d746a2829271b87bb2992d31b12f99a8e3aa73baa3</citedby><cites>FETCH-LOGICAL-c436t-f221a3005848a7ad17606d7d746a2829271b87bb2992d31b12f99a8e3aa73baa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2007.12.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20272530$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18226848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lafuente, A.</creatorcontrib><creatorcontrib>Cabaleiro, T.</creatorcontrib><creatorcontrib>Caride, A.</creatorcontrib><creatorcontrib>Esquifino, A.I.</creatorcontrib><title>Toxic effects of methoxychlor administered subcutaneously on the hypothalamic-pituitary-testicular axis in adult rats</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>This study was undertaken to evaluate the effects of methoxychlor MTX at the hypothalamic-pituitary-testicular axis in adult male rats. This global objective comprises three major aims: (1) to analyze the possible differential MTX effects in norepinephrine and serotonin concentration an in serotoninergic metabolism in anterior, mediobasal and posterior hypothalamus and median eminence; (2) to evaluate effects induced by MTX exposure on gonadotropins and testosterone; 93 to elucidate whether the regulatory interactions in the hypothalamic-pituitary-testicular axis are modified by this pesticide. Animals were administered subcutaneously 25mg/kg/day of MTX for 1 month. MTX increased norepinephrine and serotonin content in anterior hypothalamus (P⩽0.05), but decreased serotonin concentration in posterior hypothalamus (P⩽0.05). MTX diminished serotonin turnover in anterior hypothalamus (P⩽0.01) and decreased plasma LH (P⩽0.001) and testosterone (P⩽0.05) levels but those of FSH remained unmodified. We can conclude that MTX exposure: (1) could exert differential effects in norepinephrine and serotonin concentration an in serotoninergic metabolism in anterior, mediobasal and posterior hypothalamus and median eminence, being the anterior hypothalamus the most sensitive region to the pesticide; (2) could inhibit LH and testosterone secretion without changing FSH; (3) four potential pathways might be involved in MTX effects on testosterone secretion (changing LH secretion; modifying serotonin and norepinephrine at the hypothalamic level; alterating the direct neural pathway between brain and testes; and/or by a direct effect in testes).</description><subject>5-Hydroxyindole acetic acid</subject><subject>adult animals</subject><subject>Adult rats</subject><subject>animal models</subject><subject>Animals</subject><subject>biochemical pathways</subject><subject>Biological and medical sciences</subject><subject>blood chemistry</subject><subject>dietary exposure</subject><subject>endocrine-disrupting chemicals</subject><subject>Follicle stimulating hormone</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>gonadotropins</subject><subject>Gonadotropins - metabolism</subject><subject>hormone secretion</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - metabolism</subject><subject>hypothalamus</subject><subject>Hypothalamus - metabolism</subject><subject>Injections, Subcutaneous</subject><subject>insecticide residues</subject><subject>Insecticides - administration & dosage</subject><subject>Insecticides - toxicity</subject><subject>Luteinizing hormone</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>males</subject><subject>Median Eminence - drug effects</subject><subject>Median Eminence - metabolism</subject><subject>Medical sciences</subject><subject>metabolism</subject><subject>Methoxychlor</subject><subject>Methoxychlor - administration & dosage</subject><subject>Methoxychlor - toxicity</subject><subject>Norepinephrine</subject><subject>Norepinephrine - metabolism</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>pituitary gland</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><subject>subcutaneous injection</subject><subject>testes</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><subject>Testosterone</subject><subject>Testosterone - metabolism</subject><subject>toxicity</subject><subject>Toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kT2P1DAQhi0E4paDH0ADbqBLsMe7tiOq04kv6SQK7mpr4tjEqyRebAft_nt82hV0VNM88-qdZwh5zVnLGZcf9q23pQXGVMuhZVw9IRuulWik2PGnZMNA6UZ2fHdFXuS8ZxXkSj4nV1wDSL3VG7Lex2Ow1HnvbMk0ejq7MsbjyY5TTBSHOSwhF5fcQPPa27Xg4uKapxONCy2jo-PpEMuIE87BNodQ1lAwnZricgl2nbCGHEOmYalh61RowpJfkmcep-xeXeY1efj86f72a3P3_cu325u7xm6FLI0H4CgY29WqqHCo5Zkc1KC2EkFDB4r3WvU9dB0MgvccfNehdgJRiR5RXJP359xDir_W2sjMIVs3TecjDDAFQkqoID-DNsWck_PmkMJc7zCcmUfXZm-qa_Po2nAw1XXdeXMJX_vZDf82LnIr8O4CYLY4-YSLDfkvB_U9sBOscm_PnMdo8GeqzMMPYLxerrUGsa3ExzPhqqzfwSWTbXCLdUNI9W9miOE_Rf8A7MGnug</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Lafuente, A.</creator><creator>Cabaleiro, T.</creator><creator>Caride, A.</creator><creator>Esquifino, A.I.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20080501</creationdate><title>Toxic effects of methoxychlor administered subcutaneously on the hypothalamic-pituitary-testicular axis in adult rats</title><author>Lafuente, A. ; Cabaleiro, T. ; Caride, A. ; Esquifino, A.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-f221a3005848a7ad17606d7d746a2829271b87bb2992d31b12f99a8e3aa73baa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>5-Hydroxyindole acetic acid</topic><topic>adult animals</topic><topic>Adult rats</topic><topic>animal models</topic><topic>Animals</topic><topic>biochemical pathways</topic><topic>Biological and medical sciences</topic><topic>blood chemistry</topic><topic>dietary exposure</topic><topic>endocrine-disrupting chemicals</topic><topic>Follicle stimulating hormone</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>gonadotropins</topic><topic>Gonadotropins - metabolism</topic><topic>hormone secretion</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Hypothalamo-Hypophyseal System - metabolism</topic><topic>hypothalamus</topic><topic>Hypothalamus - metabolism</topic><topic>Injections, Subcutaneous</topic><topic>insecticide residues</topic><topic>Insecticides - administration & dosage</topic><topic>Insecticides - toxicity</topic><topic>Luteinizing hormone</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>males</topic><topic>Median Eminence - drug effects</topic><topic>Median Eminence - metabolism</topic><topic>Medical sciences</topic><topic>metabolism</topic><topic>Methoxychlor</topic><topic>Methoxychlor - administration & dosage</topic><topic>Methoxychlor - toxicity</topic><topic>Norepinephrine</topic><topic>Norepinephrine - metabolism</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>pituitary gland</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serotonin</topic><topic>Serotonin - metabolism</topic><topic>subcutaneous injection</topic><topic>testes</topic><topic>Testis - drug effects</topic><topic>Testis - metabolism</topic><topic>Testosterone</topic><topic>Testosterone - metabolism</topic><topic>toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lafuente, A.</creatorcontrib><creatorcontrib>Cabaleiro, T.</creatorcontrib><creatorcontrib>Caride, A.</creatorcontrib><creatorcontrib>Esquifino, A.I.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lafuente, A.</au><au>Cabaleiro, T.</au><au>Caride, A.</au><au>Esquifino, A.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxic effects of methoxychlor administered subcutaneously on the hypothalamic-pituitary-testicular axis in adult rats</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>46</volume><issue>5</issue><spage>1570</spage><epage>1575</epage><pages>1570-1575</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>This study was undertaken to evaluate the effects of methoxychlor MTX at the hypothalamic-pituitary-testicular axis in adult male rats. This global objective comprises three major aims: (1) to analyze the possible differential MTX effects in norepinephrine and serotonin concentration an in serotoninergic metabolism in anterior, mediobasal and posterior hypothalamus and median eminence; (2) to evaluate effects induced by MTX exposure on gonadotropins and testosterone; 93 to elucidate whether the regulatory interactions in the hypothalamic-pituitary-testicular axis are modified by this pesticide. Animals were administered subcutaneously 25mg/kg/day of MTX for 1 month. MTX increased norepinephrine and serotonin content in anterior hypothalamus (P⩽0.05), but decreased serotonin concentration in posterior hypothalamus (P⩽0.05). MTX diminished serotonin turnover in anterior hypothalamus (P⩽0.01) and decreased plasma LH (P⩽0.001) and testosterone (P⩽0.05) levels but those of FSH remained unmodified. We can conclude that MTX exposure: (1) could exert differential effects in norepinephrine and serotonin concentration an in serotoninergic metabolism in anterior, mediobasal and posterior hypothalamus and median eminence, being the anterior hypothalamus the most sensitive region to the pesticide; (2) could inhibit LH and testosterone secretion without changing FSH; (3) four potential pathways might be involved in MTX effects on testosterone secretion (changing LH secretion; modifying serotonin and norepinephrine at the hypothalamic level; alterating the direct neural pathway between brain and testes; and/or by a direct effect in testes).</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>18226848</pmid><doi>10.1016/j.fct.2007.12.017</doi><tpages>6</tpages></addata></record> |
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| subjects | 5-Hydroxyindole acetic acid adult animals Adult rats animal models Animals biochemical pathways Biological and medical sciences blood chemistry dietary exposure endocrine-disrupting chemicals Follicle stimulating hormone Follicle Stimulating Hormone - blood gonadotropins Gonadotropins - metabolism hormone secretion Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism hypothalamus Hypothalamus - metabolism Injections, Subcutaneous insecticide residues Insecticides - administration & dosage Insecticides - toxicity Luteinizing hormone Luteinizing Hormone - blood Male males Median Eminence - drug effects Median Eminence - metabolism Medical sciences metabolism Methoxychlor Methoxychlor - administration & dosage Methoxychlor - toxicity Norepinephrine Norepinephrine - metabolism Pesticides, fertilizers and other agrochemicals toxicology pituitary gland Rats Rats, Sprague-Dawley Serotonin Serotonin - metabolism subcutaneous injection testes Testis - drug effects Testis - metabolism Testosterone Testosterone - metabolism toxicity Toxicology |
| title | Toxic effects of methoxychlor administered subcutaneously on the hypothalamic-pituitary-testicular axis in adult rats |
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