Differences on metabolic behavior between intra and extrahepatic cholangiocarcinomas at 18F-FDG–PET/CT: prognostic implication of metabolic parameters and tumor markers
Background and purpose Cholangiocarcinoma is an infrequent neoplasm barely studied with 18 F-FDG–PET/CT. We evaluated the metabolic behavior of cholangiocarcinoma in PET/CT according to its location (intra or extrahepatic) and analyzed the relationship between metabolic parameters of the primary tum...
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| Veröffentlicht in: | Clinical & translational oncology 2019-03, Vol.21 (3), p.324-333 |
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| creator | Sabaté-Llobera, A. Gràcia-Sánchez, L. Reynés-Llompart, G. Ramos, E. Lladó, L. Robles, J. Serrano, T. Mestres-Martí, J. Gámez-Cenzano, C. |
| description | Background and purpose
Cholangiocarcinoma is an infrequent neoplasm barely studied with
18
F-FDG–PET/CT. We evaluated the metabolic behavior of cholangiocarcinoma in PET/CT according to its location (intra or extrahepatic) and analyzed the relationship between metabolic parameters of the primary tumor and tumor markers (CA19-9 and CEA), determining their prognostic significance.
Methods
Retrospective study of PET/CT of 60 patients with untreated cholangiocarcinoma, divided into two groups according to tumor location. FDG uptake was evaluated visually and semiquantitatively [SUVmax and tumor-to-liver ratio (TLR)], and differences between intra and extrahepatic cholangiocarcinomas were tested, both for FDG uptake in the primary tumor and for the presence of regional or distant disease (per-patient), as well as regarding tumor marker levels. A correlation between metabolic parameters and tumor markers was performed, and prognostic value of these factors was determined (univariate and multivariate analyses).
Results
Intrahepatic cholangiocarcinomas were significantly more FDG-avid than extrahepatic ones (
p
= 0.006 for SUVmax;
p
= 0.002 for TLR). There were differences neither between both groups considering the capacity of PET/CT to detect regional (
p
= 0.261) and distant involvement (
p
= 0.876), nor regarding the levels of tumor markers (
p
= 0.160 for CA19-9;
p
= 0.708 for CEA). Metabolic parameters and tumor markers showed a weak positive correlation (
R
2
0.22–0.27). At the multivariate analysis, advanced stage (
p
= 0.024), increased CEA (
p
= 0.022), and higher TLR (
p
= 0.003) were significantly related with shorter overall survival.
Conclusions
Intra and extrahepatic cholangiocarcinomas behave differently on PET/CT, though no differences between both groups exist in its capacity to detect regional or distant disease. Metabolic parameters and levels of tumor markers seem to relate with tumor burden, impacting in prognosis. |
| doi_str_mv | 10.1007/s12094-018-1926-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2072183983</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2072183983</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1660-d465430db8ed989fa627b8f0a498f55ddf47e33a3d14e97f2a5f748da190d7323</originalsourceid><addsrcrecordid>eNp9UctOHDEQHEVBCgE-gJuPuQzY43nYuUULC5GQksNGys3qHbd3TXbswZ7N48Y_8Bd8Fl-SXpYDJ04ut6q6qlVFcSr4meC8O8-i4rouuVCl0FVb8nfFoWi1LiVvmvcvmNfq54fiY863nKatEIfF44V3DhOGHjOLgQ04wTJufM-WuIbfPiYC0x_EwHyYEjAIluFfQmscYSJev44bCCsfe0i9D3GAzGBiQs3L-cXV0_3D98vF-WzxmY0prkLMO40fRrIgOTlG98p0hAT0w5SfjabtQAEGSL9oclwcONhkPHl5j4of88vF7Lq8-Xb1dfblpuxF2_LS1m1TS26XCq1W2kFbdUvlONRauaax1tUdSgnSihp15ypoXFcrC0Jz28lKHhWf9nsp8N0W82QGn3vc0JUYt9lUvKuEklpJooo9tU8x54TOjMlT3H9GcLPrxex7MdSL2fViOGmqvSYTN6wwmdu4TYEuekP0H17XlK4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2072183983</pqid></control><display><type>article</type><title>Differences on metabolic behavior between intra and extrahepatic cholangiocarcinomas at 18F-FDG–PET/CT: prognostic implication of metabolic parameters and tumor markers</title><source>SpringerLink Journals</source><creator>Sabaté-Llobera, A. ; Gràcia-Sánchez, L. ; Reynés-Llompart, G. ; Ramos, E. ; Lladó, L. ; Robles, J. ; Serrano, T. ; Mestres-Martí, J. ; Gámez-Cenzano, C.</creator><creatorcontrib>Sabaté-Llobera, A. ; Gràcia-Sánchez, L. ; Reynés-Llompart, G. ; Ramos, E. ; Lladó, L. ; Robles, J. ; Serrano, T. ; Mestres-Martí, J. ; Gámez-Cenzano, C.</creatorcontrib><description>Background and purpose
Cholangiocarcinoma is an infrequent neoplasm barely studied with
18
F-FDG–PET/CT. We evaluated the metabolic behavior of cholangiocarcinoma in PET/CT according to its location (intra or extrahepatic) and analyzed the relationship between metabolic parameters of the primary tumor and tumor markers (CA19-9 and CEA), determining their prognostic significance.
Methods
Retrospective study of PET/CT of 60 patients with untreated cholangiocarcinoma, divided into two groups according to tumor location. FDG uptake was evaluated visually and semiquantitatively [SUVmax and tumor-to-liver ratio (TLR)], and differences between intra and extrahepatic cholangiocarcinomas were tested, both for FDG uptake in the primary tumor and for the presence of regional or distant disease (per-patient), as well as regarding tumor marker levels. A correlation between metabolic parameters and tumor markers was performed, and prognostic value of these factors was determined (univariate and multivariate analyses).
Results
Intrahepatic cholangiocarcinomas were significantly more FDG-avid than extrahepatic ones (
p
= 0.006 for SUVmax;
p
= 0.002 for TLR). There were differences neither between both groups considering the capacity of PET/CT to detect regional (
p
= 0.261) and distant involvement (
p
= 0.876), nor regarding the levels of tumor markers (
p
= 0.160 for CA19-9;
p
= 0.708 for CEA). Metabolic parameters and tumor markers showed a weak positive correlation (
R
2
0.22–0.27). At the multivariate analysis, advanced stage (
p
= 0.024), increased CEA (
p
= 0.022), and higher TLR (
p
= 0.003) were significantly related with shorter overall survival.
Conclusions
Intra and extrahepatic cholangiocarcinomas behave differently on PET/CT, though no differences between both groups exist in its capacity to detect regional or distant disease. Metabolic parameters and levels of tumor markers seem to relate with tumor burden, impacting in prognosis.</description><identifier>ISSN: 1699-048X</identifier><identifier>EISSN: 1699-3055</identifier><identifier>DOI: 10.1007/s12094-018-1926-0</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Medicine ; Medicine & Public Health ; Oncology ; Research Article</subject><ispartof>Clinical & translational oncology, 2019-03, Vol.21 (3), p.324-333</ispartof><rights>Federación de Sociedades Españolas de Oncología (FESEO) 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1660-d465430db8ed989fa627b8f0a498f55ddf47e33a3d14e97f2a5f748da190d7323</citedby><cites>FETCH-LOGICAL-c1660-d465430db8ed989fa627b8f0a498f55ddf47e33a3d14e97f2a5f748da190d7323</cites><orcidid>0000-0002-5580-3391</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12094-018-1926-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12094-018-1926-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Sabaté-Llobera, A.</creatorcontrib><creatorcontrib>Gràcia-Sánchez, L.</creatorcontrib><creatorcontrib>Reynés-Llompart, G.</creatorcontrib><creatorcontrib>Ramos, E.</creatorcontrib><creatorcontrib>Lladó, L.</creatorcontrib><creatorcontrib>Robles, J.</creatorcontrib><creatorcontrib>Serrano, T.</creatorcontrib><creatorcontrib>Mestres-Martí, J.</creatorcontrib><creatorcontrib>Gámez-Cenzano, C.</creatorcontrib><title>Differences on metabolic behavior between intra and extrahepatic cholangiocarcinomas at 18F-FDG–PET/CT: prognostic implication of metabolic parameters and tumor markers</title><title>Clinical & translational oncology</title><addtitle>Clin Transl Oncol</addtitle><description>Background and purpose
Cholangiocarcinoma is an infrequent neoplasm barely studied with
18
F-FDG–PET/CT. We evaluated the metabolic behavior of cholangiocarcinoma in PET/CT according to its location (intra or extrahepatic) and analyzed the relationship between metabolic parameters of the primary tumor and tumor markers (CA19-9 and CEA), determining their prognostic significance.
Methods
Retrospective study of PET/CT of 60 patients with untreated cholangiocarcinoma, divided into two groups according to tumor location. FDG uptake was evaluated visually and semiquantitatively [SUVmax and tumor-to-liver ratio (TLR)], and differences between intra and extrahepatic cholangiocarcinomas were tested, both for FDG uptake in the primary tumor and for the presence of regional or distant disease (per-patient), as well as regarding tumor marker levels. A correlation between metabolic parameters and tumor markers was performed, and prognostic value of these factors was determined (univariate and multivariate analyses).
Results
Intrahepatic cholangiocarcinomas were significantly more FDG-avid than extrahepatic ones (
p
= 0.006 for SUVmax;
p
= 0.002 for TLR). There were differences neither between both groups considering the capacity of PET/CT to detect regional (
p
= 0.261) and distant involvement (
p
= 0.876), nor regarding the levels of tumor markers (
p
= 0.160 for CA19-9;
p
= 0.708 for CEA). Metabolic parameters and tumor markers showed a weak positive correlation (
R
2
0.22–0.27). At the multivariate analysis, advanced stage (
p
= 0.024), increased CEA (
p
= 0.022), and higher TLR (
p
= 0.003) were significantly related with shorter overall survival.
Conclusions
Intra and extrahepatic cholangiocarcinomas behave differently on PET/CT, though no differences between both groups exist in its capacity to detect regional or distant disease. Metabolic parameters and levels of tumor markers seem to relate with tumor burden, impacting in prognosis.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Research Article</subject><issn>1699-048X</issn><issn>1699-3055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9UctOHDEQHEVBCgE-gJuPuQzY43nYuUULC5GQksNGys3qHbd3TXbswZ7N48Y_8Bd8Fl-SXpYDJ04ut6q6qlVFcSr4meC8O8-i4rouuVCl0FVb8nfFoWi1LiVvmvcvmNfq54fiY863nKatEIfF44V3DhOGHjOLgQ04wTJufM-WuIbfPiYC0x_EwHyYEjAIluFfQmscYSJev44bCCsfe0i9D3GAzGBiQs3L-cXV0_3D98vF-WzxmY0prkLMO40fRrIgOTlG98p0hAT0w5SfjabtQAEGSL9oclwcONhkPHl5j4of88vF7Lq8-Xb1dfblpuxF2_LS1m1TS26XCq1W2kFbdUvlONRauaax1tUdSgnSihp15ypoXFcrC0Jz28lKHhWf9nsp8N0W82QGn3vc0JUYt9lUvKuEklpJooo9tU8x54TOjMlT3H9GcLPrxex7MdSL2fViOGmqvSYTN6wwmdu4TYEuekP0H17XlK4</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Sabaté-Llobera, A.</creator><creator>Gràcia-Sánchez, L.</creator><creator>Reynés-Llompart, G.</creator><creator>Ramos, E.</creator><creator>Lladó, L.</creator><creator>Robles, J.</creator><creator>Serrano, T.</creator><creator>Mestres-Martí, J.</creator><creator>Gámez-Cenzano, C.</creator><general>Springer International Publishing</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5580-3391</orcidid></search><sort><creationdate>20190301</creationdate><title>Differences on metabolic behavior between intra and extrahepatic cholangiocarcinomas at 18F-FDG–PET/CT: prognostic implication of metabolic parameters and tumor markers</title><author>Sabaté-Llobera, A. ; Gràcia-Sánchez, L. ; Reynés-Llompart, G. ; Ramos, E. ; Lladó, L. ; Robles, J. ; Serrano, T. ; Mestres-Martí, J. ; Gámez-Cenzano, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1660-d465430db8ed989fa627b8f0a498f55ddf47e33a3d14e97f2a5f748da190d7323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabaté-Llobera, A.</creatorcontrib><creatorcontrib>Gràcia-Sánchez, L.</creatorcontrib><creatorcontrib>Reynés-Llompart, G.</creatorcontrib><creatorcontrib>Ramos, E.</creatorcontrib><creatorcontrib>Lladó, L.</creatorcontrib><creatorcontrib>Robles, J.</creatorcontrib><creatorcontrib>Serrano, T.</creatorcontrib><creatorcontrib>Mestres-Martí, J.</creatorcontrib><creatorcontrib>Gámez-Cenzano, C.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical & translational oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabaté-Llobera, A.</au><au>Gràcia-Sánchez, L.</au><au>Reynés-Llompart, G.</au><au>Ramos, E.</au><au>Lladó, L.</au><au>Robles, J.</au><au>Serrano, T.</au><au>Mestres-Martí, J.</au><au>Gámez-Cenzano, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences on metabolic behavior between intra and extrahepatic cholangiocarcinomas at 18F-FDG–PET/CT: prognostic implication of metabolic parameters and tumor markers</atitle><jtitle>Clinical & translational oncology</jtitle><stitle>Clin Transl Oncol</stitle><date>2019-03-01</date><risdate>2019</risdate><volume>21</volume><issue>3</issue><spage>324</spage><epage>333</epage><pages>324-333</pages><issn>1699-048X</issn><eissn>1699-3055</eissn><abstract>Background and purpose
Cholangiocarcinoma is an infrequent neoplasm barely studied with
18
F-FDG–PET/CT. We evaluated the metabolic behavior of cholangiocarcinoma in PET/CT according to its location (intra or extrahepatic) and analyzed the relationship between metabolic parameters of the primary tumor and tumor markers (CA19-9 and CEA), determining their prognostic significance.
Methods
Retrospective study of PET/CT of 60 patients with untreated cholangiocarcinoma, divided into two groups according to tumor location. FDG uptake was evaluated visually and semiquantitatively [SUVmax and tumor-to-liver ratio (TLR)], and differences between intra and extrahepatic cholangiocarcinomas were tested, both for FDG uptake in the primary tumor and for the presence of regional or distant disease (per-patient), as well as regarding tumor marker levels. A correlation between metabolic parameters and tumor markers was performed, and prognostic value of these factors was determined (univariate and multivariate analyses).
Results
Intrahepatic cholangiocarcinomas were significantly more FDG-avid than extrahepatic ones (
p
= 0.006 for SUVmax;
p
= 0.002 for TLR). There were differences neither between both groups considering the capacity of PET/CT to detect regional (
p
= 0.261) and distant involvement (
p
= 0.876), nor regarding the levels of tumor markers (
p
= 0.160 for CA19-9;
p
= 0.708 for CEA). Metabolic parameters and tumor markers showed a weak positive correlation (
R
2
0.22–0.27). At the multivariate analysis, advanced stage (
p
= 0.024), increased CEA (
p
= 0.022), and higher TLR (
p
= 0.003) were significantly related with shorter overall survival.
Conclusions
Intra and extrahepatic cholangiocarcinomas behave differently on PET/CT, though no differences between both groups exist in its capacity to detect regional or distant disease. Metabolic parameters and levels of tumor markers seem to relate with tumor burden, impacting in prognosis.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s12094-018-1926-0</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5580-3391</orcidid></addata></record> |
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| ispartof | Clinical & translational oncology, 2019-03, Vol.21 (3), p.324-333 |
| issn | 1699-048X 1699-3055 |
| language | eng |
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| source | SpringerLink Journals |
| subjects | Medicine Medicine & Public Health Oncology Research Article |
| title | Differences on metabolic behavior between intra and extrahepatic cholangiocarcinomas at 18F-FDG–PET/CT: prognostic implication of metabolic parameters and tumor markers |
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